Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sublingual administration preparation containing total alkaloids in lotus leaf or lotus plumule, and use thereof

A technology of lotus seed heart and alkaloid, which is applied in the field of traditional Chinese medicine, can solve the problems of limited release and dissolution, poor transmucosal permeability, and inability to absorb mucous membranes, and achieves the effects of promoting drug absorption, good oral absorption, and improving stability.

Inactive Publication Date: 2015-03-18
宋金春 +2
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When administered sublingually, non-ionic drugs with an oil / water partition coefficient between 40 and 2000 are better absorbed; drugs with an oil / water partition coefficient exceeding 2000 are too fat-soluble, and their dissolution and release in saliva are difficult. Dissolution is limited, which affects absorption; drugs with an oil / water partition coefficient lower than 40 have poor transmucosal permeability, which affects absorption. The drug is ionic, and the mucosa can hardly absorb

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sublingual administration preparation containing total alkaloids in lotus leaf or lotus plumule, and use thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Example 1: Molding process

[0025] (1) Forming process of sublingual tablet

[0026] Extraction of various alkaloids from lotus leaf or lotus seed heart: Take appropriate amount of lotus leaf or lotus seed heart powder and use 3 times of 75% ethanol to repeatedly extract 3 times, each time for 3 hours, and combine the extracts each time, filter and concentrate Until there is no alcohol smell, adjust the pH of the filtrate to 7.5, precipitate and precipitate, and obtain the crude total alkaloids; (2) Purification of the crude total alkaloids in lotus leaves or lotus seeds: the above crude extracts are purified by macroporous adsorption resin method, the first Use 15% ethanol to elute for the first time, remove the eluent; use 75% ethanol to elute for the second time, collect the eluate, recover ethanol, concentrate, and dry to obtain a purified extract (each 100mg coarse powder contains total biological base 75mg). Add corresponding excipients according to the following...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of traditional Chinese pharmacology, and discloses a preparation method and a use of a sublingual administration preparation containing alkaloids extracted from lotus leaf or lotus plumule. The sublingual administration preparation can be rapidly absorbed by sublingual mucous membrane, directly enters blood, avoids first pass effect of livers, is convenient to take, and has reduced untoward effects and improved the curative effect.

Description

technical field [0001] The invention belongs to the technical field of Chinese pharmacy, and relates to a preparation method of a sublingual preparation containing alkaloids extracted from lotus leaves or lotus seeds and the application of various preparations. Background technique [0002] The lotus leaf is the leaf of Nelumbonucifera Gaertn, a plant of the water lily family, and is mainly produced in Hunan, Hubei, Fujian, Jiangsu, Zhejiang and other places. The lotus leaf is rich in various alkaloids such as liensinine, methylliensinine, isoliensinine, protonuciferine and nuciferine. The lotus leaf has the effects of clearing heat and relieving heat, promoting hair and clearing yang, dispelling blood stasis and stopping bleeding. [0003] Lianzixin is the dry young leaves and radicles of the mature seeds of Nelumbonucifera Gaertn., a plant of the water lily family. Lotus seed heart contains chemical components such as alkaloids, flavonoids, sitosterol, volatile oil and t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/62A61K9/20A61K9/16A61K9/12A61P9/12A61P9/06A61P7/02A61P39/06A61P9/10A61P9/00A61P35/00A61P11/00A61P3/10A61K127/00A61K131/00
CPCA61K9/006A61K9/12A61K9/1652A61K9/2031A61K9/2059A61K9/28A61K36/62
Inventor 宋金春杨小青沈秉正彭燕
Owner 宋金春
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com