The invention provides a method for preparing 4,6-dichloro-5-amino-2-(propylsulfanyl)
pyrimidine. The method comprises the following steps: 1, adding 4,6-dyhydroxy-2-mercaptopyrimidine into water, dripping a 10 percent
sodium hydroxide solution, adding
methanol and 1-bromopropane, reacting by keeping temperature, and acidifying to separate out crystals so as to obtain 4,6-dyhydroxy-2-(propylthio)
pyrimidine; 2, adding fuming
nitric acid into glacial
acetic acid, adding the 4,6-dyhydroxy-2-(propylthio)
pyrimidine, and adding water to separate out crystals so as to obtain 4,6-dyhydroxy-5-nitro-2-(propylthio)pyrimidine; 3, adding a chloro agent into
dichloromethane, adding the 4,6-dyhydroxy-5-nitro-2-(propylthio)pyrimidine in batches, adding saturated brine, and postprocessing to obtain 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine; and 4, adding
iron powder into an
organic solvent, adding the 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine in batches, adding
dichloromethane and water to dissolve residue, demixing, evaporating an
organic layer to
dryness under reduced pressure obtain an oily product, and adding a crystallizing
solvent to obtain the 4,6-dichloro-5-amino-2-(propylsulfanyl)pyrimidine. The method overcomes defects of the prior art, so that production cost is reduced.