Synthesis process for sodium valproate
A technology of sodium valproate and synthesis process, applied in directions such as carboxylate preparation, organic chemistry, etc., can solve problems such as low production efficiency, high cost, complicated production process, etc. The effect of more processes
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[0015] The synthetic technique of the sodium valproate of the present embodiment may further comprise the steps:
[0016] (1) Diethyl malonate and 1-bromo-n-propane are dissolved in each other, and the mixture is slowly added to the ethanol solution of sodium ethoxide at 50°C;
[0017] (2) Heat up and reflux for 2 hours, recover ethanol to 110°C, cool down to 80°C, add a certain amount of water to dissolve NaBr;
[0018] (3) Add 30% aqueous sodium hydroxide solution to the organic layer after layering, and hydrolyze at 60°C for 3 hours;
[0019] (4) Raise the temperature to recover ethanol until the gas phase temperature reaches 99°C, cool down to 80°C, add hydrochloric acid to neutralize and acidify;
[0020] (5) Add crude valproic acid to dissolve dipropylmalonic acid to form a mixed acid;
[0021] (6) Slowly heat up at 110°C for decarboxylation to generate crude valproic acid. After the crude valproic acid is refined by rectification, it is neutralized by adding a quantit...
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