The invention relates to a preparation method for a novel rubber strip for sealing of automobile doors and windows and a product. The preparation method employs ethylene propylene diene monomers as basic materials with cooperation of certain amounts of carbon black, calcium carbonate, paraffin oil, zinc oxide, stearic acid, polyvinyl alcohol, high-molecular wax, compound antioxidants, dispersants, compound accelerants, vulcanizing agents, fire retardants and the like. The above materials are subjected to mixing, open milling and vulcanization technologies to obtain the rubber strip. The preparation method has advantages of simple formula, simple production technology, short vulcanizing time, high production efficiency, relatively low production cost, easy industrialization enforcement and the like. The rubber product for sealing is advantaged by good sealing performance, uniform structure, resistance to corrosion, resistance to high and low temperature, flame resistance, environment protection and comfort.