The invention discloses a compound fruit and vegetable beverage capable of improving human body hypoxia tolerance. The compound fruit and vegetable beverage is prepared from, by weight, 3-7 parts of black Chinese wolfberry pulp juice, 5-9 parts of a spirulina extracting solution, 3-7 parts of grape pulp juice, 4-6 parts of a green tea extracting solution, 2-4 parts of kale pulp juice, 3-7 parts of peanut pulp juice, 3-7 parts of oat pulp juice, 3-4 parts of carrot pulp juice, 7-12 parts of yam pulp juice, 5-7 parts of cherry pulp juice, 5-7 parts of kiwi fruit pulp juice, 4-8 parts of strawberry pulp juice and 12-15 parts of honey. The invention further discloses a preparation method of the raw materials. According to the compound fruit and vegetable beverage, the raw materials are green, the cost is low, and the compound beverage which can improve the human body hypoxia tolerance is obtained through effective compounding of the fruits and vegetables; the compound fruit and vegetable beverage can be drunk for a long term, is free of toxic and side effects, free of traditional Chinese medicine ingredients and sour, sweet and palatable in taste, can effectively relieve the symptoms such as different degrees of dizziness, dysmnesia, obnubilation, slow organism response, aching pain and debilitation and hand and foot numbness which are generated due to the fact that people who work and live in an oxygen-deficient environment and highly mental labor people lack oxygen and has the good market prospect.