142results about How to "Improve tumor treatment effect" patented technology

The invention relates to a portable high-voltage nanosecond squarer which belongs to a medicinal device for inducing cancer cell apoptosis by using a high-voltage nanosecond square wave pulse electric field. The portable high-voltage nanosecond squarer mainly comprises a power supply system, a high-voltage direct current module, a low-voltage power supply, a pulse forming system and a pulse shaping and counting system. The portable high-voltage nanosecond squarer has output pulses with highest amplitude of 15kV, pulse width adjustment range of 50ns-1us, rising edge gradient of reaching 10ns and controllable recurrence frequency of 0.2-15Hz; and the quantity of the output pulses of the portable high-voltage nanosecond squarer can be set. The portable high-voltage nanosecond squarer can be adjusted in multiple-parameters (pulse amplitude, pulse width, recurrence frequency, pulse quantity and the like), large-range and flexible and independent way, and is beneficial to researching the optimal window parameter of the cancer cell apoptosis and promoting the cancer cell apoptosis as well as improving the cancer treatment effect. Meanwhile, the portable high-voltage nanosecond squarer has compact and light structure, reliable work, simple operation and convenient popularization and application, and can be widely applied to the treatment of various cancers.

The invention discloses an ultra-small MoS2 nanosheet. The surface of the MoS2 nanosheet is modified with polyvinylpyrrolidone, and the diameter of the modified MoS2 nanosheet ranges from 15 nm to 25 nm. The invention further discloses a preparation method of the ultra-small MoS2 nanosheet. The preparation method comprises the following steps: a sulfur source and a molybdenum source are dissolved in water and stirred until the resources are completely dissolved; polyvinylpyrrolidone is dissolved in the solution of the sulfur source and the molybdenum source; the solution is transferred into a stainless steel reaction kettle with a polyphenyl lining for closed reaction, a reaction product is washed with an ethanolamine water solution and distilled water, and the ultra-small MoS2 nanosheet with the surface modified with polyvinylpyrrolidone is obtained. The invention further provides an application of the ultra-small MoS2 nanosheet as a photo-thermal conversion material. The ultra-small MoS2 nanosheet has good colloid stability, photo-thermal conversion capacity and photo-acoustic imaging capacity and has broad application prospect in the fields of tumor treatment and the like.

The invention discloses a co-delivery nano-carrier of drugs and genes, a preparation method and an application thereof; and particularly relates to a co-delivery nano-carrier TCPL-siRNA-PPX which can carry a chemotherapeutic drug and a genetic drug simultaneously. The drug delivery system is composed of a polymer prodrug carrier TCPL, siRNA and a multifunctional polyanionic polyer PPX through electrostatic adsorption among the components in a self-assembly manner. The co-delivery nano-carrier can achieve targetedly delivery of the drug and the gene to the same tumor cell, release the siRNA at the cytoplasm, silence Bcl-2 protein, promote apotosis and relieve inhibition of the Bcl-2 on lonidamine, and can deliver the chemotherapeutic drug, lonidamine, which is mitochondrion-acted to mitochondria so that the chemotherapeutic drug and the gene can synergistically trigger the apotosis of a mitochondrial pathway and kill tumor cells cooperatively. Through in-vivo and in-vitro activity evaluation, the drug delivery system is proved to be better than drug delivery carriers which deliver single components respectively at the same time, can significantly improve the anti-cancer activity of the drug and the gene and has a definite synergistic treatment effect.

The invention provides a hollow manganese dioxide nano-particle as well as a preparation method and application thereof. The preparation method comprises: a silver nanocube is first prepared, and thenthe silver nanocube is used as a template, and the hollow manganese dioxide nano-particle is synthesized with a template method in a one-step process; the hollow manganese dioxide nano-particle has the characteristics of being simple in preparation process and the like; at the same time, the hollow manganese dioxide nano-particle, prepared with the method, has the advantages of stable properties,controllable size and structure and the like, and can be applied in the fields of drug carriers, tumor treatment, magnetic resonance imaging and the like.

The invention discloses a nano-carrier for drug and gene co-delivery and a preparation method and application thereof, and particularly relates to a co-delivery nano-carrier TCPL-siRNA-PPX for simultaneously carrying a chemotherapeutic drug and a gene-based drug. A polymeric prodrug carrier TCPL, siRNA and a multifunctional polyanionic polymer PPX are self-assembled by electrostatic adsorption between ingredients to form the drug delivery system; a drug and a gene can be targeted to be delivered to the same tumor cell, and moreover, siRNA is released in cytoplasm to silence the Bc1-2 protein, promoting apoptosis and releasing the inhibition of Bcl-2 on lonidamine; the chemotherapeutic drug acting on mitochondria, lonidamine, is delivered to the mitochondria; both cooperatively trigger the apoptosis of the mitochondrial pathway, jointly killing the tumor cell. By in-vitro and in-vivo activity evaluation, the invention proves that the system is better than the simultaneous delivery of each single component, can remarkably increase anti-cancer activity, and has a definite synergistic treatment effect.

The invention discloses a targeted nano carbon quantum dot carrier CQDs-PEG-Tf of an accessory immune cell therapy and a preparation method thereof and application of a carrier mediated antitumor drug an immune cells in the targeted tumor therapy. It is proved through in vitro experiments that the carrier can be combined with the tumor cell surface over-expression receptor specifically, and the good biological safety to immune cells is achieved by means of a carrier mediated antitumor drug under a certain concentration. The carrier mediated antitumor drug is combined with the immune cells to double target and kill tumor cells, the double anti-tumor effect is achieved, and toxic and side effects of the antitumor drug on normal cells can be reduced. The carrier is simple in preparation method and easy to carry out and has a high targeting property, nontoxicity, excellent biocompatibility and biodegradability. The carrier can be applicable to preparation of targeted anticancer drugs and the targeted therapy of accessory immune cells on various cancer diseases.

The invention discloses a liposome-gadolinium meso-porous silicon compound for cancer combined therapy and three kinds of imaging, and a preparation method thereof. The preparation method comprises the following steps: preparation of GdMSNs; preparation of DOX@GdMSNs; and preparation of DOX@GdMSNs-ICG-TSLs. The liposome-gadolinium meso-porous silicon compound DOX@GdMSNs-ICG-TSLs for cancer combined therapy and three kinds of imaging can be excited by a near-infrared light source, and has the advantages of realization of phototherapy and chemotherapy combined therapy, realization of fluorescence, photoacoustic and nuclear magnetic imaging integration, good biocompatibility, great improvement of the tumor treatment effect, reduction of toxic and side effects, and simplicity and easiness in preparation and use.

The invention discloses a polymer nanocarrier capable of promoting endocytosis and cell nucleus targeting and a preparation method of the polymer nanocarrier. The polymer nanocarrier material is an amphipathic block polymer, a hydrophobic end is a polyester capable of being biologically degraded and absorbed, a hydrophilic chain segment is polyethylene glycol with a terminal linked with polypeptide capable of promoting endocytosis and cell nucleus targeting, the polypeptide is modified by a small molecule, and an amido bond, linked with the polypeptide, of the small molecule responds to a faintly acid environment of tumors, so that the endocytosis and the nucleus targeting drug delivery are promoted; and a cell nucleus can be targeted by virtue of a cell nucleus targeting signal. The polymer nanocarrier material and medicines can form medicine-carrying nanoparticles in water through self-assembling, and the preparation method is simple.

The invention provides a gynostemma pentaphylla saponin long-circulating liposome preparation and a preparation method thereof. The invention discloses a method for preparing gynostemma pentaphylla saponin long-circulating liposome after modification of beta-sitosterol by polyethylene glycol. Compared with common phosphatide polyethylene glycol modified long-circulating liposome, the gynostemma pentaphylla saponin long-circulating liposome prepared in the invention has the following advantages: material synthesis cost is greatly reduced, separation is easier, yield is substantially increased, and cost for the long-circulating liposome is substantially reduced. The novel long-circulating liposome has the characteristics of easy and wide availability of raw materials, a cheap price, good stability, capacity of substantially prolonging detention time of gynostemma pentaphylla saponin in a human body, realizing passive targeting of gynostemma pentaphylla saponin to tumor cells and improving tumor treatment effects and an excellent antihyperlipidemic effect.

The invention provides a medicine composition for treating tumors and an application thereof. The medicine composition is composed of acriflavine or pharmaceutically acceptable salts thereof, melphalan or pharmaceutically acceptable salts thereof, and a medicinal carrier, wherein the molar ratio of the acriflavine to the melphalan is 1:100 to 1:10, and the tumors comprise blood tumors and solid tumors. The forms of the medicine comprise single preparations prepared from acriflavine or melphalan respectively, or a compound preparation prepared from acriflavine and melphalan. The medicine composition provided by the invention has the effects of improving the curative effect on tumors, the toxicity of the medicine composition can be reduced, and the growth speeds of the tumors can be slowed down.

The invention relates to a portable high-voltage nanosecond squarer which belongs to a medicinal device for inducing cancer cell apoptosis by using a high-voltage nanosecond square wave pulse electric field. The portable high-voltage nanosecond squarer mainly comprises a power supply system, a high-voltage direct current module, a low-voltage power supply, a pulse forming system and a pulse shaping and counting system. The portable high-voltage nanosecond squarer has output pulses with highest amplitude of 15kV, pulse width adjustment range of 50ns-1us, rising edge gradient of reaching 10ns and controllable recurrence frequency of 0.2-15Hz; and the quantity of the output pulses of the portable high-voltage nanosecond squarer can be set. The portable high-voltage nanosecond squarer can be adjusted in multiple-parameters (pulse amplitude, pulse width, recurrence frequency, pulse quantity and the like), large-range and flexible and independent way, and is beneficial to researching the optimal window parameter of the cancer cell apoptosis and promoting the cancer cell apoptosis as well as improving the cancer treatment effect. Meanwhile, the portable high-voltage nanosecond squarer has compact and light structure, reliable work, simple operation and convenient popularization and application, and can be widely applied to the treatment of various cancers.

The invention provides a preparation method of a cancer cell membrane chimeric liposome nano drug delivery system. The preparation method comprises the following steps of: dissolving high-purity cholesterol, hydrogenated soybean phospholipid, distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 and indometacin in absolute ethyl alcohol under a dark condition to prepare an ethanol solution; carrying out rotary evaporation on the obtained ethanol solution to form a thin film; hydrating the thin film to obtain a hydrated thin film; adding a cancer cell membrane suspension solution into the hydrated thin film and extruding to obtain chimeric indometacin liposome; mixing the chimeric indometacin liposome and ZSTK474 carrier-free nanoparticles; and extruding to obtain the cancer cell membrane chimeric liposome nano drug delivery system. By adopting the preparation method of the cancer cell membrane chimeric liposome nano drug delivery system, provided by the invention, an active targeting function on tumor tissues is increased, the anti-tumor efficiency of a drug is easy to improve and the dosage of a tumor cell membrane is extremely saved; and the preparation method is convenient for clinical application.