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Mesoporous polydopamine loaded manganese carbonyl multifunctional nano diagnosis and treatment agent and preparation method and application thereof

A technology of mesoporous polydopamine and polydopamine, applied in the field of biomedical materials, can solve the problems of high cost, poor repeatability, complicated preparation process, etc., and achieve good light-to-heat conversion efficiency and photostability

Active Publication Date: 2018-08-24
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the nano-diagnostic agents reported at home and abroad usually involve a variety of chemical reagents and drugs, and the preparation process is complex, high cost, low efficiency, poor repeatability, and difficult to achieve clinical application.

Method used

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  • Mesoporous polydopamine loaded manganese carbonyl multifunctional nano diagnosis and treatment agent and preparation method and application thereof
  • Mesoporous polydopamine loaded manganese carbonyl multifunctional nano diagnosis and treatment agent and preparation method and application thereof
  • Mesoporous polydopamine loaded manganese carbonyl multifunctional nano diagnosis and treatment agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Synthesis of nano-diagnostic agent MnCO@MPDA

[0038] Specific steps are as follows:

[0039] (1) The synthesis of the carrier mesoporous polydopamine MPDA was prepared according to the prior art, and the particle size was 210 nm.

[0040] (2) Synthesis of MnCO@MPDA: Dissolve 1.5 mg MnCO in 1 mL methanol, 300 μg MPDA in 1 mL methanol, mix the two evenly, and place them in a vacuum drying oven until the volume of the solvent evaporates to 500-600 When μL was removed, it was centrifuged at 13000 rpm for 10 min, and the resulting precipitate was MnCO@MPDA, which could be resuspended in water or PBS (pH 7.4) solution.

Embodiment 2

[0041] Example 2 Synthesis of nano-therapeutic agent MnCO@MPDA

[0042] Specific steps are as follows:

[0043] (1) The synthesis of the carrier mesoporous polydopamine MPDA was prepared according to the prior art, and the particle size was 210 nm.

[0044] (2) Synthesis of MnCO@MPDA: Dissolve 1.5 mg MnCO in 1 mL of methanol and 1.5 mg of MPDA in 1 mL of methanol, mix the two, and place them in a vacuum oven until the volume of the solvent evaporates to 500-600 μL Take it out and centrifuge at 13000rpm for 10 min, the obtained precipitate is MnCO@MPDA, which can be resuspended in water or PBS (pH 7.4) solution.

Embodiment 3

[0045] Example 3 Characterization of nano-therapeutic agent MnCO@MPDA

[0046] Specific steps are as follows:

[0047] (1) Determination of MPDA nitrogen adsorption / desorption curve: take a dried 100 mg MPDA sample, and measure the nitrogen adsorption / desorption curve with the instrument, such as figure 2 As shown in (a) and (b), the specific surface area of ​​the MPDA nanoparticles prepared in Example 1 is calculated by using the BJH method to be 21.8603 m² / g, and the pore size is about 10 nm.

[0048] (2) The morphology of MnCO@MPDA was observed by transmission electron microscope (TEM): Take 10 μL of MnCO@MPDA dispersion liquid, drop it on the surface carbon-coated copper grid, and let it dry naturally at room temperature. Under the condition of 200kV voltage, the morphology and particle size of nanoparticles were observed by transmission electron microscope. Such as figure 2 As shown in (c), the transmission electron microscopy results of the nanoparticles MnCO@MPDA p...

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Abstract

The invention discloses a mesoporous polydopamine loaded manganese carbonyl multifunctional nano diagnosis and treatment agent and a preparation method and an application thereof. The multifunctionalnano diagnosis and treatment agent is a water-soluble mesoporous polydopamine carrier-coated hydrophobic manganese carbonyl drug, wherein the mass ratio of mesoporous polydopamine to manganese carbonyl is 1-8:1. The multifunctional nano diagnosis and treatment agent realizes gas and photo-thermal collaborative treatment under MRI and photoacoustic imaging guiding, is hopeful for increasing tumourtreatment effect, has good biocompatibility, and has clinical application potential.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a multifunctional diagnosis and treatment agent and a preparation method thereof. Background technique [0002] At present, in order to achieve accurate diagnosis and efficient treatment of diseases, the designed diagnostic and therapeutic agents often need to have the functions of multimodal imaging and treatment at the same time. Traditional methods such as surgery, radiotherapy, and chemotherapy are commonly used clinically to treat cancer, which not only has many side effects but also has poor curative effect, and it is difficult to completely eradicate malignant tumors. Near-infrared light-mediated photothermal therapy of tumors has attracted much attention in recent years as a superior local treatment method. Due to its deep tissue penetration ability and tissue safety, photothermal therapy combined with photothermal conversion agents can achieve effective k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/18A61K49/22A61K41/00A61K33/32A61K9/51A61K47/34A61P35/00B82Y5/00B82Y15/00
CPCA61K9/5146A61K33/32A61K41/0052A61K49/0002A61K49/1857A61K49/225A61P35/00B82Y5/00B82Y15/00A61K2300/00
Inventor 曹众管青青武丹
Owner SUN YAT SEN UNIV
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