The invention relates to the technical field of medical equipment, and especially relates to an intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin. The cabin comprises a cabin body, a cabin door installed on the cabin body, a gas inlet unit, a vacuum pump unit and a control system used for controlling the air inlet unit and the vacuum pump unit. The gas outlet end of the gas inlet unit is communicated with the cabin body, and the gas inlet end of the vacuum pump unit is communicated with the cabin body; and the intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin provided by the invention can perform intermittent low-pressure and low-oxygen alternation. Under the hypoxia condition, degradation of a hypoxia inducible factor-1 alpha (HIF-1alpha) is affected and is combined with an HIF-1beta subunit to form a dimer, then the dimer is combined with a hypoxia response element, transcription of hundreds of genes in cells is activated, and the hypoxia inducible factor-1 alpha (HIF-1alpha) has a treatment effect on various diseases such as depression, insomnia, dementia, autism and arthralgia.