The invention discloses a water-soluble
florfenicol clathrate with high
bioavailability. The water-soluble
florfenicol clathrate is prepared from the following components in parts by weight: 5-15 parts of
florfenicol or pharmaceutically acceptable salt of florfenicol, 20-60 parts of a florfenicol adsorption carrier, 1-2 parts of an absorption
promoter, and 10-30 parts of a florfenicol cosolvent. For the florfenicol clathrate provided by the invention, the
solubility of florfenicol is effectively improved, the
bioavailability of florfenicol is improved, the
hemolysis property of the
medicine is alleviated, the release rate of the
medicine is controlled, and the bad smell is masked. The preparation method provided by the invention comprises the following steps: firstly, mixing the florfenicol adsorption carrier, the absorption
promoter and the florfenicol cosolvent, adding with florfenicol or the pharmaceutically acceptable salt of florfenicol under the water bath water control condition, carrying out stirring, carrying out heat preservation, and carrying out
drying, thus obtaining the florfenicol clathrate. The technological operation is simple, the abundant time and manpower are saved, and during the preparation process, no organic solvents are used, so that the preparation method is safe and reliable and is free of
pollution, and the process is simple and easy to realize.