The invention discloses a novel enzyme thick pulp and a preparation method thereof, and relates to the field of health care products, the novel enzyme thick pulp comprises the following components by weight: 45-55% of purified water, 0.8-1.2% of earthworm protein, 7-11% of enzyme, 7-11% of agkistrodon halys, 8-10% of yolk powder, 5-8% of collagen, 2-3% of phospholipid, and the balance of auxiliary materials. According to the invention, the earthworm protein, the agkistrodon halys, the collagen and the enzyme are added, and then the preparation method is adopted, so that the novel enzyme thick pulp becomes thick pulp type beverage, and can be used for transforming cells, repairing necrotic cells and promoting metabolism; detoxification, detoxification, blood purification and physique improvement are realized; the novel enzyme thick pulp has the effects of enhancing immunity, improving self-healing capacity, decomposing cancerogenic substances and cancer bud cells, preventing hypertension, myocardial infarction, arrhythmia and stroke embolism, dredging collaterals, relieving pain and detoxifying, and plays an important role in the physiological functions of growth and metabolism of human cells, regulation of heart and brain organs and prevention of angiosclerosis.