The invention relates to a slope vibration table model test device and method considering hydro-fluctuation belt rock mass degradation, and belongs to the field of geotechnical engineering. The devicecomprises a model box system, a water circulation system and a positioning frame system, wherein the model box system comprises a model box bottom steel plate, a model box middle frame box, a model box upper steel frame, model box upper transparent tempered glass and a model box back steel plate, the water circulation system comprises a small water storage tank, a water inlet pipe, a large waterstorage tank, a water outlet pipe and a water pump, and the positioning frame system comprises a steel vertical frame, a movable steel span beam and a movable steel bar. The method comprises the stepsof assembling a model box system, building a slope model, hoisting the model box system, assembling a water circulation system, assembling a position finding frame system, debugging equipment, starting the water circulation system and loading seismic waves. The device can be used in cooperation with existing equipment in a barrier-free mode and has the design advantages of being visual, detachable, compact in structure, wide in application range and the like.