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62 results about "Tertiary butyl acetate" patented technology

Tert-Butyl acetate, t-butyl acetate or TBAc is a colorless flammable liquid with a camphor- or blueberry-like smell. It is used as a solvent in the production of lacquers, enamels, inks, adhesives, thinners and industrial cleaners.

Process for producing important synthesis midbody of high purity atorvastatin

The invention relates to a method for preparing high-purity (4R, 6R)-6-{2-[5-isopropyl-3-phenyl-2(4-fluorophenyl)-4-(phenylcarbamoyl)-yrrol-1-yl]- ethyl}-2, 2-dimethyl-[1, 3]-dioxane-4-yl-tert-butyl acetate, which comprises the following steps: step one, [5-methyl-4-isopropyl-2-phenyl-1(4-fluorophenyl)-3-(phenylcarbamoy1)-1,4-hexanedione](II) and [(4R,6R)-2,2-dimethyl-6-(2-aminoethyl)-[1,3]-dioxane-4-yl-tert-butyl acetate](III) with a mol ratio of between 0.71 and 1.12 to 1 are weighed, an acid catalyst which is 1.05 to 1.15 times of mol number of the formula (II) is weighed, the mixture is dissolved in a non-hydroxy solvent which is 3.0 to 4.2 times of the weight of the formula (II) under the protection of nitrogen and the stirring, and heating reflux and azeotropic water entrainment are performed until an HPLC shows that the reaction is finished; and second two, the solvent is removed under vacuum, then a water-isopropanol mixed solvent with a volume ratio of 2 to 5 is used to recrystallize the mixture, and a key intermediate of synthetic atorvastatin calcium which has an HPLC purity not less than 99.0 percent and is expressed by the formula (I) is obtained after the pump filtration and drying. The method has the advantages of simple process, low equipment requirement, low cost, convenient and quick recovery of the solvent, less environmental pollution, and high product purity.
Owner:安徽美诺华药物化学有限公司

3-site substituted (1-iso-indoxoline-2-base)piperidine-2,6-thiazolidinedione and synthetic method thereof

The invention discloses a 3-site substituted (1-iso-indoxoline-2-base)piperidine-2,6-thiazolidinedione and a synthetic method thereof, and belongs to the technical field of medicine synthesis. In a formula I, Y can be Z, R1, R2, -(CH2)n-R3, wherein Z is a boric acid ester group or a boric acid group, R1 is hydroxyl, cyanogroup or trifluoromethyl, R2 is morpholinyl, piperidyl and methyl piperazinegroup; in the formula -(CH2)n-R3, R3 is alkylene, tert-butyl acetate, phenyl group and heterocyclic aromatic group, and n is 0 or 1. The compound can be used for preparing medicines capable of treating or preventing multiple myeloma, leukemia and lymphoma. The formula is shown in the description.
Owner:EAST CHINA NORMAL UNIVERSITY

Preparation process of tert-butylhydroquinone

The invention relates to the technical field of antioxidant preparation methods, and particularly relates to a preparation process of tert-butylhydroquinone (TBHQ). The preparation process comprises the following steps of (1) simultaneously adding excessive dilute sulphuric acid, equimolar hydroquinone and tertiary butyl acetate to a reaction still, wherein the weight ratio of the dilute sulphuric acid to the tertiary butyl acetate is 1:(3 to 6); (2) stirring and heating to 85 to 95 DEG C, and reacting for 1 to 8 hours; (3) stopping stirring, cooling to 65 to 75 DEG C, and then performing centrifugal filtration, wherein filtrate of sulphuric acid is recycled, and obtained filter residues are washed with 1 to 3 times warm water, so as to obtain a crude product of the TBHQ. Compared with the prior art, the preparation process has the advantages that the hydroquinone and the tertiary butyl acetate are used as raw materials, and the dilute sulphuric acid is used as a catalyst and a reaction solvent, so as to promote a reaction; tertiary butyl is supplied by the tertiary butyl acetate, so that side reactions are reduced; the crude product contains 70% to 75% of TBHQ, the content of DTBHQ (Di-Tert-Butylhydroquinone) as a by-product is low, the yield can reach 65 to 70% after purification, the yield is greatly increased, and great economic benefits are obtained.
Owner:东莞市感恩食品科技有限公司

Environment friendly energy conservation fuel and preparation thereof

The present invention relates to an environment-friendly energy saving fuel, which is characterized in that the environment-friendly energy saving fuel comprises dimethyl ether. Further, the environment-friendly energy saving fuel also comprises an energy saving synergist. The compositions in portion by weight of the synergist are: 10 to 20 portions of methyl tert-butyl ether; 5 to 15 portions of tertiary butyl acetate; 10 to 20 portions of acetone; 10 to 20 portions of cyclopentanone; 5 to 15 portions of xylene; 10 to 20 portions of petroleum ether; and, 5 to 15 portions of ethanol. The environment-friendly energy saving fuel improves the combustion performance of the fuel with the flame temperature being high. The fuel reaches the same combustion efficiency with the consumption amount of the fuel gas being saved by between 20 and 50 percent. Additionally, the price of dimethyl ether is relatively cheap. Specifically, the price of dimethyl ether: the price of the rest burning gas is 5:6 to 7, i.e., people can save the cost of fuel by largely using dimethyl ether as fuel or part of fuel. The reduction of the consumption amount of the rest burning gases facilitates the reduction of the side effect of the burning gases. The present invention also relates to a preparation method of the environment-friendly energy saving fuel.
Owner:堆龙德庆金晋企业管理有限公司

Process for separating tert-butyl acetate in medicine waste solvent through vacuum rectification by using super-gravity bed

The invention relates to a vacuum rectification method using a super-gravity bed as core separating equipment, and discloses a process for separating and recycling a waste solvent in the synthetic process of statins or other medicines and recovering tert-butyl acetate in the solvent. During operation, the waste solvent enters from a place located between the two-layer and three-layer rotors of thesuper-gravity bed, wherein the rotating speed is 1000r/min, the reflux ratio is 4-10, the vacuum degree at the top of a tower is 20kPa-70kPa, and the temperature of a tower kettle is controlled at 70DEG C-85 DEG C, a tert-butyl acetate product with higher purity can be recovered in the tower kettle, the purity can reach 95% or more, the residual amount of isoprene is less than 1%, and the moisture content is less than 1000ppm, thereby fully meeting the requirements of recycling; and compared with traditional tower-type rectification operation, the process provided by the invention has the advantages of having a simple technological procedure, low energy consumption, a small occupied area of equipment, and high recovery rate of the product tert-butyl acetate, and being capable of effectively improving economic benefits.
Owner:南京揽博环境技术有限公司 +1

Water-resistant composite additive for vehicular fuel oil

InactiveCN104164260ADestruction of oxidation conditionsDestroy anti-oxidant and anti-corrosionLiquid carbonaceous fuelsImidazolidineTert butyl phenol
The invention provides a water-resistant composite additive for vehicular fuel oil. The water-resistant composite additive is prepared from the following components in percentage by weight: 40-70% of mutual solvent, 20-40% of oxidization-corrosion inhibitor, 2-6% of bactericide and 8-14% of auxiliaries; the mutual solvent comprises the following components in percentage by weight: 10-30% of methyl tert-butyl ether, 10-15% of tert-butyl acetate, 15-20% of dimethyl carbonate, 40-50% of a mixture of C3-C6 higher alcohols, and 5% of N-ethylpyrrolidine; the oxidization-corrosion inhibitor comprises the following components in percentage by weight: 30-50% of 2,6-tert-butyl phenol, 10-15% of Bis(1-methylpropyl)-1,4-phenylenediamine, 20-30% of T1201, 15-20% of methyl benzotriazole and 5% of a mixture of ethoxylated alkylphenol and oil-soluble imidazolidine according to the weight ratio of 6:4; the bactericide comprises the following components in percentage by weight: 40-60% of dioxolakylborane-containing solution, 15-30% of N-benzylideneaniline, 10-15% of polyethylene glycol borate, and 15% of 2-methyl-4-Isothiazolin-3-one; and the auxiliaries comprise the following components toluene, aviation kerosene, dioctyl sebacate and cyclohexane according to the weight ratio of 3:2:1:4. The water-resistant composite additive can effectively solve the problems that the vehicular fuel oil causes phase separation, serious corrosion and wear to an engine, and the like when absorbing water during production and storage and transportation.
Owner:ENERGY & ENVIRONMENT RES INST OF HEILONGJIANG PROVINCE

Preparation method of Nalpha-fluorenylmethoxycarbonyl-glutamine tert-butyl ester

The invention discloses a preparation method of Nalpha-fluorenylmethoxycarbonyl-glutamine tert-butyl ester and mainly solves the technical problems of complexity, long period, low yield, high cost and the like of an original technology. The preparation method comprises steps as follows: step one, gln and tert-butyl acetate are mixed, and h-gln-otbu is prepared under the action of perchloric acid; or, gln and z-cl are mixed, z-gln-oh is prepared and mixed with tert-butyl acetate, z-gln-otbu is prepared and subjected to catalytic hydrogenation in methyl alcohol, and h-gln-otbu is prepared; step two, h-gln-otbu and a fmoc-group protective agent are mixed, pH value is regulated to 8-9 by an alkali compound sodium carbonate aqueous solution in the presence of an organic solvent, fmoc-gln-otbu is prepared through reaction, and a pure product of fmoc-gln-otbu is prepared through processing. With the adoption of setting of a reasonable process route, Nalpha-fluorenylmethoxycarbonyl-glutamine tert-butyl ester and an intermediate thereof are prepared, and Nalpha-fluorenylmethoxycarbonyl-glutamine tert-butyl ester is applicable to mass production.
Owner:上海吉尔多肽有限公司 +1

A kind of preparation technology of tert-butyl hydroquinone

The invention relates to the technical field of antioxidant preparation methods, and particularly relates to a preparation process of tert-butylhydroquinone (TBHQ). The preparation process comprises the following steps of (1) simultaneously adding excessive dilute sulphuric acid, equimolar hydroquinone and tertiary butyl acetate to a reaction still, wherein the weight ratio of the dilute sulphuric acid to the tertiary butyl acetate is 1:(3 to 6); (2) stirring and heating to 85 to 95 DEG C, and reacting for 1 to 8 hours; (3) stopping stirring, cooling to 65 to 75 DEG C, and then performing centrifugal filtration, wherein filtrate of sulphuric acid is recycled, and obtained filter residues are washed with 1 to 3 times warm water, so as to obtain a crude product of the TBHQ. Compared with the prior art, the preparation process has the advantages that the hydroquinone and the tertiary butyl acetate are used as raw materials, and the dilute sulphuric acid is used as a catalyst and a reaction solvent, so as to promote a reaction; tertiary butyl is supplied by the tertiary butyl acetate, so that side reactions are reduced; the crude product contains 70% to 75% of TBHQ, the content of DTBHQ (Di-Tert-Butylhydroquinone) as a by-product is low, the yield can reach 65 to 70% after purification, the yield is greatly increased, and great economic benefits are obtained.
Owner:东莞市感恩食品科技有限公司

Biological synthesis method of atorvastatin intermediate

The invention discloses a biological synthesis method of an atorvastatin intermediate. The biological synthesis method comprises the following step: carrying out enzyme catalysis reaction on a compound (4R,6R)-6-(1-amino-1-carboxylethyl)-2,2-dimethyl-1,3-dioxane-4-tert-butyl acetate under the action of amino acid decarboxylase to generate a compound (4R,6R)-6-(aminoethyl)-2,2-dimethyl-1,3-dioxane-4-tert-butyl acetate, i.e., the atorvastatin intermediate. The biological synthesis method disclosed by the invention has moderate reaction conditions and no special requirements on equipment; a chemical synthesis method is combined with an enzyme method and pollution to the environment is not caused; reaction conditions are easy to control, the operation is simple and convenient and a technological flow is simple.
Owner:ZHEJIANG HONGYUAN PHARMA

Method for preparing rosuvastatin calcium intermediate

The invention discloses a method for preparing a rosuvastatin calcium intermediate. The name of the intermediate is 2-[(4R, 6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-yl]-tert-butyl acetate. The preparation method comprises the following steps: (1) preparing an intermediate I; (2) preparing an intermediate II; (3) preparing an intermediate III; and (4) preparing the 2-[(4R, 6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-yl]-tert-butyl acetate. The method has the beneficial effects that active hydroxyl in an initial material is protected in the reaction process disclosed by the invention, side reaction is reduced, the technique is improved, the reaction efficiency is improved, and the method is applicable to large-scale industrial production.
Owner:NANTONG CHANGYOO PHARMATECH CO LTD

Pitavastatin calcium intermediate preparation method

The invention discloses a pitavastatin calcium intermediate preparation method, and relates to the technical field of preparation of pitavastatin calcium intermediates. In the prior art, the Wittig reaction can generate a large amount of solid waste triphenyl phosphorus oxychloride, and the solid waste is difficult to completely remove through post-treatment purification. A purpose of the presentinvention is to solve the problem in the prior art. The preparation method comprises: 1, carrying out a reaction on (2-cyclopropyl-4-(fluorophenyl)quinoline-3-yl)methanol I and phosphorus tribromide in dichloromethane to form 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline II, and extracting with dichloromethane; 2, carrying out a Reformatsky reaction on the 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline II and 2-((4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxane-4-yl)tert-butyl acetate to obtain an alcohol VII; and 3, adding p-toluenesulfonyl chloride in a dropwise manner to obtain p-toluenesulfonate VIII, treating the reaction liquid with potassium tert-butoxide, and carrying out an elimination reaction to obtain 2-((4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-yl) tert-butyl acetate V, or directly treating with a sodium carbonate aqueous solution to obtain the product V.
Owner:安庆恩聚生物医药科技有限公司

Far infrared anion nanometer solution

InactiveCN106422150AAvoid harmDirect fusionChemical protectionBetaineLow speed
The invention discloses a far infrared anion nanometer solution. The far infrared anion nanometer solution is composed of the ingredients of, by weight, 100 parts of anion powder, 400 parts to 600 parts of distilled water, 6 parts to 8 parts of sodium polyacrylate, 12 parts to 15 parts of dodecyl polyglucoside, 4 parts to 6 parts of ethylene glycol, 10 parts to 12 parts of ethyleneurea, 4 parts to 6 parts of citric acid, 6 parts to 8 parts of zirconia, 12 parts to 15 parts of dodecyl dimethyl betaine, 15 parts to 18 parts of tert-butyl acetate, and 10 parts to 15 parts of alkoxy type titanate coupling agent. The ingredients are mixed and soaked for 2 days to 3 days, and then placed into a ball mill to be subjected to low-speed ball milling for 2 hours to 3 hours and high-speed ball milling for 40 minutes to 60 minutes, and the far infrared anion nanometer solution is obtained. According to the far infrared anion nanometer solution, a permanent nanoscale anion film is formed on the surface of a pollution source to decompose formaldehyde before formaldehyde escapes into the air, formaldehyde is prevented from causing harm to human bodies, anion release can be triggered only by slight changes of temperature and pressure without light irradiation under any room temperature states to decompose formaldehyde, and because the far infrared anion nanometer solution is colorless and odorless, the surfaces of furniture are not damaged.
Owner:昆山倍善环保实业有限公司
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