52 results about "Schizandrin B" patented technology

The invention relates to a traditional Chinese medicine composition used for treating male sterility, a preparation method and a quality control method thereof. The traditional medicine composition contains crude drugs such as fruits of Chinese wolfberry, dodder (fried), raspberry, fructus schizandrae (steamed), plantago seeds (fried with salt) and the like. The preparation method comprises an ultrafine grinding technology and the like. The quality control method of the medicine composition comprises a thin-layer identification method for fruits of Chinese wolfberry, dodder, raspberry, fructus schizandrae and plantago seeds as well as a method for measuring the content of schizandrin B in the plantago seeds. The medicine composition has obvious therapeutic effect in treating renal deficiency and lumbago, post-micturition dribble, spermatorrhea, premature ejaculation, impotence and sterility.

The invention belongs to the field of traditional Chinese medicines or the pharmaceutical chemistry, and relates to a use of schisandrin B or a Chinese magnoliavine extract in the preparation of medicines for treating and / or adjunctively treating and / or preventing liver fibrosis or liver cirrhosis, medicines for treating or adjunctively treating diseases caused by the liver fibrosis or liver cirrhosis, or medicines for inhibiting liver stellate cell proliferation or DNA synthesis. The invention also relates to a method for inhibiting the liver stellate cell proliferation or inhibiting the liver stellate cell DNA synthesis in vitro / in vivo, and a medicinal composition containing the schisandrin B or the Chinese magnoliavine extract. It is proved that the schisandrin B can obviously improve the liver fibrosis or the liver cirrhosis degree, has no obvious hepatotoxicity and has a good application prospect.

The invention discloses application of monomeric compounds of fruits of Chinese magnoliavine (Schisandra chinensis(Turcz.) baill. and Schisandra sphenanthera Rehd.et Wils) to preparation of medicine for preventing and treating cholestasis liver diseases. The monomeric compounds of fruits of Chinese magnoliavine refer to Schisandrin B, Schisandrin C, Schisandrol A, Schisantherrin A and Schisantherrin B. The result of the study shows that all of the five kinds of monomeric compounds can obviously reduce the content of total bile acids and direct bilirubin in blood serum in the cholestasis liverdisease state, can relieve the cholestasis symptoms, can reduce the activity of alkaline phosphatase, gamma-glutamyltransferase, aspartate transaminase and / or alanine aminotransferase in the liver, and can effectively improve the liver tissue necrosis degree. The invention discovers the condition for the first time that the five kinds of monomeric compounds of fruits of Chinese magnoliavine can beused for effectively preventing and treating the cholestasis liver diseases induced by liithocholic acid. The discovery provides the powerful technical theoretical basis for the new medicine researchand development for the cholestasis liver diseases and the clinic application of the monomeric compounds of fruits of Chinese magnoliavine; and wide application prospects are realized in the field ofcholestasis prevention and treatment.

The invention relates to the technical field of medicine. The main characteristic components of Schisandra chinensis are lignans, which include schisandrin A, schisandrin B, schisandrin C, etc. Modern pharmacological experiments show that lignans have liver protection and anti-oxidation properties. Various pharmacological activities. The invention provides new medical applications of schisandrin B and schisandrin C components, specifically the application in the preparation of anti-hepatic fibrosis drugs. The pharmacodynamic studies of the present invention show that Schizandrin B and Schisandra C can significantly reduce the concentrations of ALT and AST in the serum of liver fibrosis model rats induced by common bile duct ligation and CCL4, improve the symptoms of liver fibrosis, and have good anti-inflammatory effects. Liver fibrosis activity, so it can be used to prepare anti-hepatic fibrosis medicine or health food.

The invention discloses an application of schisandrin B in the preparation of a drug for preventing colitis or colon cancer; the dosage of the schisandrin B is 15-30 mg / kg body weight; the schisandrin B can effectively prevent colitis and colitis-related colon cancer, has clinical application prospects; Schizandrin B has low toxicity and few side effects, which can reduce the production of inflammatory factors; Schizandrin B has good drug-making properties; therefore, Schizandrin B has good clinical application prospects for preventive treatment.

The invention belongs to the technical field of the detection of components of traditional Chinese medicines, and discloses a detection method of effective components of radix seu caulis schisandrae propinquae and application. The detection method comprises steps of preparation of standard substance solutions of rutin, schizandrin A and schisandrin B respectively, preparation of a test sample solution, HPLC (High Performance Liquid Chromatography) detection and the like, wherein chromatographic conditions of the HPLC detection are as follows: a methanol-1 percent glacial acetic acid solution is used as mobile phase eluent; the gradient elution is carried out for 90min; volume fractions of methanol in the eluent corresponding to each time interval of the elution are respectively: 20 percentduring 0min to 20min, 40 percent during 20min to 40min, 60 percent during 40min to 60min, 80 percent during 60min to 80min and 100 percent during 80min to 90min; a flow speed is 1mL / min; a detectionwavelength is 257nm. The detection method uses the HPLC detection with the gradient elution, can be used for measuring three functional effective components in the radix seu caulis schisandrae propinquae at the same time, and can be used for more completely reflecting a pharmacodynamic effect of the radix seu caulis schisandrae propinquae.

The invention relates to a method for processing vinegar schisandra fruit, which can effectively prepare medicinal material of the schisandra fruit into vinegar schisandra fruit medical herb in pieces. The invention has the concrete technical scheme comprises the following steps: taking the medicinal material of the schisandra fruit, removing the non-medicinal parts such as fruit stalks, stumps and the like, adding rice vinegar, decompressing and moistening until the rice vinegar is sucked up, braising at high pressure, drying and packaging so as to obtain the vinegar schisandra fruit. The method is simple and easy to operate, the color of the prepared vinegar schisandra fruit is uniform, and the indexes of the contents of water content, ash content and the like are all within a range specified by a dispensatory; compared with a normal-pressure vinegar braising product of the vinegar schisandra fruit, no obvious difference exists in the contents of general lignanoid, schisandrol A, schisandra fruit essence B and general organic acid; compared with the normal-pressure vinegar braising product, the contents of 5-hydroxymethyl furfural and general polysaccharide are higher; and compared with a traditional normal-pressure braising process, the processing method adopting high-pressure vinegar braising lowers energy consumption and saves time. Therefore, the invention can be popularized and used for large-scale production, provides concrete technical data for the processing of the vinegar schisandra fruit and provides ground for the execution of the standardized production operation rule of traditional Chinese medicine medical herb in pieces.