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Preparation method of liver protection tablets

A liver-protecting tablet and Bupleurum bupleurum technology, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of large dosage for patients, rough process, and impact on application, and achieve the effect of reducing dosage

Inactive Publication Date: 2012-12-19
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of Hugan Tablets. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects this product. products in clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 250g of Bupleurum, 250g of capillary, 250g of Banlangen, 300g of Schisandra, 20g of pig gall powder, and 128g of mung beans, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. Minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract, add starch , 70% ethanol granules, dried, compressed into 1000 tablets, each weighing 0.4g, each containing about 1g of crude drug.

[0022] After testing, the content of Schizandrin B in the finished product is 0.53 mg / tablet.

Embodiment 2

[0024] Take 250g of bupleurum, 250g of capillary, 250g of Radix Isatidis, 300g of schisandra, 20g of pig gall powder, and 128g of mung beans, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 600W. Minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract, add starch , 70% ethanol granules, dried, compressed into 1000 tablets, each weighing 0.4g, each containing about 1g of crude drug.

[0025] After testing, the content of Schisandra B in the finished product is 0.68mg / tablet.

Embodiment 3

[0027] Take 250g of bupleurum, 250g of capillary, 250g of Radix Isatidis, 300g of schisandra, 20g of pig gall powder, and 128g of mung beans, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 500W. Minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract, add starch , 70% ethanol granules, dried, compressed into 1000 tablets, each weighing 0.4g, each containing about 1g of crude drug.

[0028] After testing, the content of Schizandrin B in the finished product is 0.65mg / tablet.

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PUM

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Abstract

The invention provides a preparation method of liver protection tablets. The liver protection tablets are prepared from the raw material medicines of 250g of radix bupleuri, 250g of herba artemisiae scopariae, 250g of radix isatidis, 300g of fructus schisandrae chinensis, 20g of pig bile powder and 128g of mung bean by microwave extraction. Through the invention, the content of schisandrin b is greatly increased.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of liver-protecting tablets. Background technique [0002] Hugan Tablets are recorded in the Pharmacopoeia Standards. It is made from 250g of Bupleurum, 250g of Capillary, 250g of Radix Radix, 300g of Schisandra, 20g of Pig Gall Powder, and 128g of Mung Bean. It has the function of reducing transaminase. For chronic hepatitis and early cirrhosis. [0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of Hugan Tablets. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects this product. products in clinical application. Contents of the invention [0004] Purpose of the invention: In order to solve the above problems, the purpose of the...

Claims

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Application Information

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IPC IPC(8): A61K36/57A61P1/16A61K35/413
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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