A surgical tissue
adhesive composition contains at least one 1,1-disubstituted
electron-deficient olefin macromer. The
adhesive composition of the invention has improved
biocompatibility as well as controlled
biodegradation characteristics and bioactivity.
Adhesive co-
monomer compositions contain at least one macromer with a pendant
oligomer,
polymer, or
peptide chain as an acrylic ester of the reactive olefin. The polymers formed therefrom have a grafted
brush-like nature. The composition is particularly useful for creating an
adhesive bond at the junction of living tissue in surgical applications. The adhesive composition may further comprise co-
monomer, co-macromer, cross-
linker, or inter-penetrating
polymer compounds containing
peptide sequences that are bioactive or
enzyme responsive. The
peptide sequences are selected to promote tissue infiltration and healing in a particular
biological tissue. The sequences may contain specific
cell-adhesion,
cell-signaling, and
enzyme-cleavable domains. Furthermore, a degradable filler material may be included in the composition to create a reinforced composite. The filler preferably has a higher degradation rate than the
polymer matrix, generating
porosity upon degradation. The adhesive may further contain entrapped or incorporated drugs or biologics, including
antibiotics or growth factors. The adhesive can be used to bind together the edges of living tissues during
surgical procedures. The cured composition provides
interfacial bonding and mechanical fixation while promoting tissue infiltration and replacement of the adhesive polymer.