68 results about "Raphanin" patented technology

Production of raphsulfane with brassin vegetables as raw materials is carried out by crushing for seeds, flowers, stems and leaves, hydrolyzing at specific pH value by myrosase, extracting by acetic ether, adsorbing by silica gel, removing impurities by acetic ether and eluting by mixed solution of isopropyl alcohol, alcohol and petroleum ether. It's cheap and simple and can be used for large-scale industrial production.

The invention discloses a preparation method of a pH sensitiveness raphanin chitosan microsphere. The preparation method comprises the following steps: 1) dissolving chitosan powder into an acetic acid solution; 2) taking a raphanin water solution and adding into the acetic acid solution; and 3) dropping a sodium tripolyphosphate solution into the mixture liquid obtained in the step 2) so as to obtain the raphanin-chitosan microsphere. The preparation method of the pH sensitiveness raphanin chitosan microsphere is reasonable in design, and the microsphere is prepared by using an ionic cross-linking method in a mode that the chitosan is taken as a carrier and the sodium tripolyphosphate is taken as a cross-linking agent, the experiment is simple and mild, and no organic solvents are used, so that the method is safe and environmental-friendly, a drug carrying microsphere solution of which the average particle size is 500 nm is successfully prepared, and moreover the prepared microsphere solution is good in stability and has no great change in particle size after being placed for a long time; under the acidic condition, the raphanin can be released more easily, and the higher the pH value is, the longer the releasing time is, and therefore the microsphere is an ideal slow release formulation of the raphanin.

The invention discloses an extraction method of raphanin. The extraction method comprises the following steps: preparing broccoli powder from stems and / or leaves of broccoli, mixing 2 parts of broccoli powder, 15 to 25 parts of external mustard seed enzyme solution and 10 parts of phosphoric acid buffering solution with the pH of 4.0 to 6.0, forming a primary mixed solution, successively performing the enzymolysis, freeze drying, extraction and suction filtering for the primary mixed solution, obtaining raphanin extraction solution, performing the rotary evaporation for the raphanin extractionsolution to obtain raphanin extract, re-dissolving the extract by using 50 percent acetonitrile, chromatographically collecting by using half prepared liquid phase, and obtaining a raphanin pure product. The proportion of the broccoli powder, the external mustard seed enzyme liquid and the phosphoric acid buffering solution is g: mL: mL. The raphanin is extracted from a broccoli byproduct, so that the byproduct utilization rate can be greatly improved, the additional value of the broccoli can be increased, and the resource waste can be reduced. The process parameters are optimized by virtue of a single-factor experiment and response surface experiment, and a raphanin extraction method which is simple in operation, simple in equipment, rapid, high in efficiency, and high in product puritycan be obtained.

The invention relates to a preparation method of a raphanin capsule capable of being stored stably. The preparation method comprises the following steps: (1) adding water to raphanin embedded ingredients to form an ingredient solution, wherein the ingredients comprise alpha-cyclodextrin, trehalose and citric acid; (2) after mixing raphanin liquid with the ingredient solution, carrying out treatment by adopting a homogenizer to obtain a raphanin microemulsion; (3) drying the raphanin microemulsion through a spray dryer to obtain raphanin powdery solid particles; and (4) carrying out capsule filling on the powdery solid particles to obtain the raphanin capsule capable of being stored stably. Compared with the prior art, raphanin can be embedded into an annular cavity of alpha-cyclodextrin, the exterior of the cavity is closed by using sodium alga acid, and due to the fact that air, oxygen and the like are isolated, the raphanin capsule can be stored at normal temperature and can be stored at the temperature of 25 DEG C for one year, and the content of raphanin is decreased by less than 2%.

The invention provides a composition with blood pressure, blood fat and blood glucose reducing efficacy. The composition comprises, by weight, 30-50 parts of Chinese yam, 1-10 parts of celery, 1-12 parts of lotus leaves, 1-10 parts of semen cassia, 2-10 parts of radix puerariae, 2-13 parts of semen raphanin,2-15 parts of hawthorn, 2-11 parts of poria, 3-13 parts of red kojic rice, 3-20 parts of fructus gardenia, 1-10 parts of radix polygoni multiflori preparata, 6-20 parts of radix astragali and 3-15 parts of carrot. The composition is wide in application range, fast in taking effect, low in recurrence, fit to eat by populations at different ages, and Chinese herbs, vegetables, composites and the like are combined according to the health preservation concept of focusing on maintenance and combining prevention to achieve the purpose of blood pressure, blood fat and blood glucose reduction. The composition is green, safe, suitable for drinking for long time, stable and reliable, and has food therapy effect of blood pressure, blood fat and blood glucose reduction.

The invention discloses a broccoli leftover extractive and a preparation method thereof. The method comprises the following steps of: (1) pulping broccolis and carrying out ultrasonic-assisted enzymolysis on pulp; and (2) extracting broccoli raphanin and flavonoid compounds, respectively adding ethanol and water to carry out microwave-assisted reflowing extraction, combining extraction solutions obtained by two times of reflowing extraction, recycling alcohol by decompressing, continually concentrating the recovered alcohol to be paste, and drying the paste in vacuum to obtain the broccoli leftover extractive. The preparation method disclosed by the invention has the characteristics that a complex enzyme preparation, ultrasonic-assisted extraction and microwave-assisted extraction are applied to the extraction of effective components in broccoli leftovers; and compared with the prior art, the preparation method improves the additional value of the broccoli leftovers greatly and the yield of the raphanin and flavonoid compounds, and also has the characteristics of low energy consumption, moderate extraction condition and low cost. The broccoli leftover extractive can be widely applied to the fields of bulk pharmaceutical chemicals, biochemical engineering and health-care foods, and has wide market prospect.

The invention provides a medicine to cure coryza. The medicine contains the effective ingredients of radix puerariae, magnolia liliflora, fructus xanthii, cimicifuga foetida, fructus aurantii, raphanin, dyers woad leaf, woad root of dyer, honeysuckle, dandelion, chrysanthemum, ageratum, liquorice and milk veteh, etc. based on a certain proportion. Application results show that the invention can quickly kill harmful bacteria caused by coryza and get into the nasal cavity tissues to repair the cells of the nasal mucosa tissues and can relieve swelling, headache, dizziness and dryness and itch with good effects. The invention can adjust sympathetic nerves in the nasal cavity, ensure the smooth instruction conduction of the nerves and help the nose to recover the normal olfactory function. The invention can also improve sleep quality, keep the nose breathe smooth and ensure sweet sleep without impairing brains and influencing study. The invention can develop a protection film inside the nasal cavity to prevent secondary germina infection and prevent rhinitis recurrence.

The invention discloses a method for continuously preparing raphanin, and particularly relates to a method for preparing raphanin from radish seeds. The raphanin with the purity of over 98 percent is prepared by performing crushing, degreasing and hydrolysis on air-dried radish seeds serving as raw materials, mounting a raphanin continuous hydrolysis column and a raphanin continuous hydrolysis separation system and preparing raphanin liquid and a raphanin-enriched macroporous adsorption resin column through separation and freeze-drying. The raw materials are readily available, and the method is high in operability; equipment is easily obtained, and the technology is simple; the production process is safe, and industrial production is facilitated. A raphanin product with the activities of preventing and resisting cancers can be widely applied to the industries such as medicines and health products.

The invention discloses a composition with a function of relaxing the bowel. The composition is prepared from 80-100 parts of psyllium seed husk powder, 1-10 parts of fructus crataegi freeze-dried powder, 1-5 parts of bunge cherry seeds, 1-5 parts of fructus cannabis, 5-10 parts of semen raphanin, 1-5 parts of apricot kernels, 30-60 parts of galactooligosaccharide, 20-40 parts of lactitol, 30-50 parts of mannan-oligosaccharide, 10-20 parts of inulin, 1-15 parts of Arabic gum, 5-10 parts of wheat fibers, 5-10 parts of citrus fibers and 1-5 parts of sesame seed powder. The composition can significantly improve the effect of relaxing the bowel, promote gastrointestinal motility and defecating, shorten defecating time, shorten excrement staying time, soften excrement, promote intestinal motility and adjust distribution of intestinal flora.

The invention discloses a chemical synthetic method for raphanin and belongs to the technical field of drug synthesis. The chemical synthetic method for raphanin comprises the following three steps of: (1) reacting sodium methyl mercaptide with 1-bromo-4-chlorobutane to generate 1-chloro-4-methyl butyl sulfide; (2) in the presence of a phase transfer catalyst, reacting sodium thiocyanate with 1-chloro-4-methyl butyl sulfide, performing dichloromethane extraction after reaction, and performing rotary evaporation on an organic layer to obtain 1-isothiocyano-4-methyl butyl sulfide; and (3) dissolving 1-isothiocyano-4-methyl butyl sulfide in dichloromethane, performing oxidation by m-chloroperoxybenzoic acid, producing a reaction, and performing purification to obtain a product, namely raphanin. The chemical synthetic method is simple and convenient to operate, requires a few steps, and is high in yield and suitable for large-scale production.

The invention relates to a feed additive for producing selenium-rich beef. The feed additive is characterized by being prepared from the following substances in parts by weight: 15-25 parts of 30% enveloped mercaptamine, 8-12 parts of dihydropyridine, 130-150 parts of cardamine violifolia, 110-130 parts of honeysuckle, 90-110 parts of roots of Chinese pulsatilla, 70-90 parts of medicated leaven, 70-90 parts of malt, 70-90 parts of semen raphanin, 70-90 parts of fructus aurantii, 70-90 parts of fructus quisqualis, 30-50 parts of acetohydroxamic acid, 50-60 parts of commercially available selenium yeast which contains 2000mg / kg of selenium, 50-60 parts of commercially available bacillus subtillis and 50-70 parts of medical stones. The feed additive for producing selenium-rich beef has the advantages of preventing various diseases of cattle, providing safe, nutritious and healthy food for the citizens, being the best food and way for selenium supplementation of the citizens, and having important practical significance.

The invention discloses a traditional Chinese medicine composition for treating hyperosteogeny. The traditional Chinese medicine composition is prepared from the following raw material medicines: notopterygium incisium, radix angelicae tuhuo, rhizoma ligustici wallichii, angelica, radices paeoniae rubra, safflower, cortex eucommiae, radix dipsaci, kakuda figwort root, fructus schizandrae, rhizoma polygonati, radix rehmanniae, Wu Chia Pee, radix astragali, radix codonopsitis, pearl barley, rhizoma atractylodis, semen raphanin, rhizoma cibotii, ephedra, radix aconiti carmichaeli, asarum, radices puerarire, radix clematidis, phellodendron and herba epimedii. The raw material medicines are ground and pulverized to carefully prepare pills. The medicine has a reasonable formula and high healing rate.

The invention relates to a natural pharmaceutical composition. The natural pharmaceutical composition is prepared from radish seed and long pepper water decoction and concentration extract, raphanin, ethanol extract of long pepper and piperine in a ratio of (3-6):(3-8):(2-5):(4-6). The composition has great curative effects on cancer chemotherapy-induced diarrhea and meanwhile has a synergistic effect on cancer chemotherapy.

The invention relates to a broccoli bud seedling rich in raphanin and a germinating method thereof. The germinating method comprises the following steps that 1 soaking is performed, wherein broccoli seeds are soaked in sub-acidic electrolysis water with the best available chlorine concentration (ACC) of 10-50 mg / L for 3-3.5 hours; 2, budding culture is performed, wherein the soaked seeds are uniformly put in a budding utensil containing the electrolysis water, and budding is performed for 7.5-8.5 days. The germinating method adopts the electrolysis water as a unique culture solution for broccoli seed budding, the raphanin content in the bud seedling is remarkably improved, the budding process is convenient, quick, safe and reliable, and the highest raphanin content in the broccoli bud seedling is up to 6.80 mg / g.

The invention relates to the medicine preparation field, in particular to a composite raphanin juice for curing aged constipation, which is composed of radish seed, rhubarb, Magnolia officinalis, immature Bitter Orange, aloe, white potato and honey; the radish seed is baked to present yellow and then smashed into powder which can pass through 100-hole screen, the white potato is peeled off and can be extracted by juice extractor, the fresh wide and thick aloe leave is peeled off, and the mesophyll of the aloe is taken out and smashed and filtered by gauze, and the juice of the aloe is prepared for use; the rhubarb, the Magnolia officinalis and the immature Bitter Orange are decocted to prepare the medicine liquid, the medicine liquid is added with the white potato juice and then churned up and decocted by small fire; the honey, the aloe juice and the radish seed are added into and mixed evenly after seething to obtain composite radish seed juice; the medicine is characterized in that the component materials are as following by weight ratio: 30-32 percent of radish seed, 20-22 percent of white potato, 15-20 percent of honey, 13-17 percent of aloe, 5-8 percent of rhubarb, 5-8 percent of Magnolia officinalis and 5-8 percent of immature Bitter Orange.

The invention provides an antihypertensive traditional Chinese medicinal composition and a preparation method thereof. The antihypertensive traditional Chinese medicinal composition is prepared from the following raw materials in parts by mass: 12 to 18 parts of radix puerariae, 10 to 14 parts of stigma maydis, 3 to 5 parts of radix aristolochiae, 4 to 6 parts of semen raphanin, 3 to 7 parts of root of asparagus cochinchinensis, 4 to 6 parts of radix codonopsis, 9 to 14 parts of fructus crataegi, 5 to 10 parts of semen cassiae, 6 to 9 parts of radix scutellariae, 6 to 11 parts of chrysanthemum indicum, 2 to 6 parts of leaf of apocynum venetum, 4 to 8 parts of eucommia bark, 5 to 9 parts of harlequin glorybower leaf and twig and 3 to 8 parts of stephania tetrandra. The antihypertensive traditional Chinese medicinal composition has a remarkable curative effect on hypertension, has a certain effect of lowering blood glucose and blood fat, has the effects of invigorating stomach, tonifying spleen, tonifying Qi and preserving health, is free from toxic and side effects, prevents relapse, and is worthy of popularization.

The invention relates to a method for obtaining raphanin from a broccoli hairy root culture system. The method comprises the following steps: (1) inoculating broccoli hairy root to a liquid medium, carrying out proliferation culture and freeze drying, and grinding into powder, thus obtaining lyophilized hairy root powder; (2) grinding newly harvested mustard seeds, carrying out ultrasonic oscillation extraction, and carrying out suction filtration to remove impurities, thus obtaining a crude enzyme; (3) adding the crude enzyme into the lyophilized hairy root powder, carrying out enzymolysis and ultrasonic oscillation extraction, and carrying out vacuum filtration to remove impurities, thus obtaining raphanin crude extraction liquid; (4) concentrating the raphanin crude extraction liquid, and extracting to obtain an ethyl acetate phase A; (5) extracting the liquid medium, thus obtaining an ethyl acetate phase B; (6) mixing the ethyl acetate phase A and the ethyl acetate phase B, and carrying out vacuum concentration and dissolution on the mixture, thus obtaining raphanin methanol solution; (7) carrying out vacuum concentration on the raphanin methanol solution, thus obtaining a raphanin crude extract; and (8) drying the raphanin crude extract to obtain a raphanin crude product with the purity being 5-30%. The method is simple and efficient.

The invention relates to the technical field of foods and particularly discloses an anti-tumor tabletted candy containing raphanin and procyanidine B2 and a preparation method thereof. The tabletted candy comprises the following components: raphanin powder, procyanidine B2, maltodextrin, microcrystalline cellulose, magnesium stearate and a sweetening agent. The tabletted candy is prepared by the steps of mixing the components, and carrying out tabletting. By virtue of the synergistic effect of procyanidine B2 and raphanin, the stabilities of procyanidine B2 and raphanin are improved, and procyanidine B2 and raphanin can continuously and efficiently exert effects of resisting oxidization and clearing in-vivo free radicals respectively in a direct way and an indirect way and show a remarkable tumor inhibition effect.

The present invention relates to a nature drug composition, a preparation method and uses of the nature drug composition in preparation of attenuation synergism drugs in cancer chemotherapy. The nature drug composition comprises an extract, raphanin, a common yam rhizome ethanol extract and a common yam rhizome polysaccharide according to a ratio of 2-:2-5:5-9:1-4, wherein garden radish seed and common yam rhizome are subjected to water decoction concentration to obtain the extract. The composition provides good treatment effects for diarrhea related to cancer chemotherapy, and provides synergism effects for cancer chemotherapy.

The invention provides an environmental-friendly non-pollution multi-functional cleaning agent gentle to hands. The cleaning agent is prepared from the raw materials: components A: natural sea salt, natural glaucine, a surface active agent, gramisterol, cycloartenyl, an oxidizing agent, nanometer coral calcium powder and sodium citrate; components B: a radix stemonae extract, a cortex phellodendriextract, a semen raphanin extract and a capillary wormwood herb extract; components C: a flos lonicerae extract, a Chinese honeylocust fruit extract, a fructus cnidii extract, a polygonum cuspidatumextract and an aloe extract; a component D: alkaloid. The environmental-friendly non-pollution multi-functional cleaning agent gentle to hands provided by the invention can be used for easily removingheavy oil stains in the kitchen; is capable of quickly decomposing the oil stains and adsorbing the decomposed oil stains at the same time, and convenient to clean; is gentle to hands at the same time.

The invention discloses an HPLC (High Performance Liquid Chromatograph) quantitative detection method for raphanin of a raphanin extract. The HPLC quantitative detection method comprises the following steps: 1, diluting a raphanin standard substance to form standard solutions with a series of concentration by an acetonitrile-water solution; 2, weighing a raphanin extract to be tested and dissolving the raphanin extract to be tested in the acetonitrile-water solution to form a sample solution; 3, respectively performing HPLC on the standard substance solution and the sample solution so as to obtain the area of absorption peaks of raphanin in the standard substance solution and the sample solution; 4, establishing a raphanin standard curve; and 5, substituting the peak area of raphanin of the sample solution in a curve equation so as to obtain the content of raphanin in the sample solution and finally obtain the content of raphanin in the raphanin extract to be tested.

The invention discloses an extract of asparagus leftovers and a preparation method thereof. The method comprises (1) ultrasonically assisted enzymolysis after beating the asparagus; (2) extracting asparagus sulforaphane and flavonoids, respectively adding ethanol and The water is subjected to microwave-assisted reflux extraction, the extracts from the two reflux extractions are combined, the alcohol is recovered under reduced pressure and concentrated to a paste, and then vacuum-dried to obtain the asparagus leftovers extract. The present invention is characterized in that compound enzyme preparation, ultrasonic-assisted extraction and microwave-assisted extraction are applied to the extraction of active ingredients in asparagus leftovers. It has the characteristics of low energy consumption, mild extraction conditions, and low cost. The asparagus leftover extract is widely used in the fields of raw materials, biochemicals, and health food, and has a broad market prospect.

The invention relates to a health-care food capable of protecting the liver, nourishing the lung, moisturizing the intestine and expelling toxins and a making method of the health-care food. The health-care food comprises the following raw material components in parts by weight: 4-6 parts by weight of plant polyphenols, 4-6 parts by weight of euglenophyta powder, 0.05-0.15 part by weight of raphanin, 4-6 parts by weight of yeast beta-glucan, 9-11 parts by weight of chenopodium quinoa powder, 4-6 parts by weight of fructus hippophae powder and 4.5-5.5 parts by weight of green papaya powder. Thehealth-care food provided by the invention can effectively prevent and assist in treating liver cancer, lung cancer, colon cancer, breast cancer, prostatic cancer and the like, can strengthen the immune adjustment function of human bodies, can eliminate hazardous substances of heavy metals, haze dust and the like, can strengthen the functions of resisting bacteria and resisting viruses, and has the efficacy of protecting the liver, nourishing the lung, moisturizing the intestine, expelling toxins, and preventing and treating various common diseases and frequently-occurring diseases.

The invention belongs to the technical field of anti-mildew and antibacterial agents, and particularly relates to a novel anti-mildew and antibacterial agent and a preparation method and application thereof. The novel anti-mildew and antibacterial agent is prepared from the components in weight by parts: 10-30 parts of aminomethyl-n-butyl propyl iodide, 6-10 parts of a water-soluble polymer, 10-15parts of hydroxyalkyl chitosan, 10-15 parts of amino oligosaccharide, 8-12 parts of raphanin, 6-10 parts of a biosurfactant, 8-12 parts of a cottonrose hibiscus leave extractive, 10-15 parts of a compound extractive of indigo naturalis, celastrus orbiculatus and imperata root, 6-10 parts of sedum sarmentosum extract and 40-50 parts of water. According to the novel anti-mildew and antibacterial agent, a fabric prepared by the impregnation or dip rolling has the properties of deodorization, corrosion resistance and the like, the antibacterial rate to escherichia coli and staphylococcus aureus is high, the antibacterial rate still remains at a high level after 30 times of washing, thus the human health is protected, and the wearing performance of clothes is improved.

The invention relates to application of raphanin in preparation of a pharmaceutical composition for improving and treating white hair and / or alopecia and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises raphanin as an effective component, and based on the total weight of the pharmaceutical composition, the weight percentage of the raphanin is 0.1-50%. The pharmaceutical composition provided by the invention shows a very significant effect in the aspect of improving and treating white hair and / or alopecia, and has the characteristics of short drug action time, significant drug effect, wide applicable population and the like.

The invention discloses a glucoraphanin and moringa oleifera extract composition buccal tablet and application thereof, and belongs to the technical field of food. The moringa oleifera extract is obtained by uniformly mixing extracts of moringa oleifera leaves, moringa oleifera stems or moringa oleifera seeds with maltodextrin and then performing spray drying. The moringa oleifera buccal tablet comprises the following components in parts by weight: 60-80 parts of moringa oleifera extract, 5-10 parts of glucoraphanin, sodium carboxymethyl cellulose and / or citric acid and / or menthol and / or cane sugar and / or magnesium stearate, and the moringa oleifera buccal tablet is formed by extruding through a punching machine after mixing. The thermal stability of myrosinase in the moringa seed extract is higher than that of broccoli extract, and the moringa seed extract still has good stability at 85 DEG C. The glucoraphanin can be subjected to stable enzymolysis in the oral cavity and the digestive tract to generate the sulforaphane. The high-activity sulforaphane is provided for the human body.

The invention discloses a traditional Chinese medicinal preparation for treating hyperplasia of mammary glands. The traditional Chinese medicinal preparation is prepared from the following traditional Chinese medicinal materials by weight: 10g of kudzuvine root, 7g of honeysuckle, 2g of raspberry, 3g of cacumen platycladi, 2g of eleutherococcus senticosus, 2g of fructus corni, 5g of herba houttuyniae, 5g of semen raphanin, 2g of rhodiola rosea, 2g of carapax et plastrum testudinis, 3g of ilex latifolia thumb, 12g of rhizoma fagopyri dibotoryis, 5g of siraitia grosvenorii, 3g of semen pruni, 5g of coix seed, 2g of allium macrostemon bunge, 1g of radix astragali, 2g of fritillaria hupehensis, 1g of apocynum venetum and 3g of rosa laevigata michx. According to the traditional Chinese medicinal preparation for treating the hyperplasia of mammary glands, the aims of good curative effect and no toxic or side effects can be achieved; in addition, the used active pharmaceutical ingredients are low in price and are easily obtained.

The invention relates to a Chinese medicinal composition, which consists of a semen raphani gallnut decocted concentrated extract, raphanin and a gallnut acetone extract in a ratio of 2-6:3-7:1-7. The composition has excellent efficacy on cancer chemotherapy related diarrhea and can have a synergistic effect on cancer chemotherapy at the same time.

The invention relates to composition for improving complexion. The composition is prepared from the following components: brown sugar, pure powdered milk, waxgourd seeds, radix angelicae, sweet almonds, Poria cocos cream, semen ginkgo pulp, rhizoma bletillae, Raphanus sativus with leaves, radix asparagi and edible pearl powder. The composition is prepared through steps as follows: peeling the waxgourd seeds, placing the waxgourd seeds in an oven, regulating the oven temperature to 120 DEG C and baking the waxgourd seeds for 1 minute; grinding the semen raphanin with leaves, placing the powder in water 5 times the amount of the powder for decoction for 0.5-1 hour, and performing filtration to obtain semen raphanin juice; grinding the prepared waxgourd seeds, the radix angelicae, the sweet almonds, the rhizoma bletillae, the radix asparagi and the edible pearl powder into 150-180-mesh fine powder, putting the fine powder into reed juice, adding water two times the mass of the fine powder, decocting the mixture for 2 hours, filtering the mixture, adding the brown sugar and the pure powdered milk for concentration into thick paste, drying and grinding the thick paste into active ingredients in 120-140 meshes, and preparing a product in a designed dosage form with a conventional method. The product for improving complexion is convenient to take and good in complexion improving effect and tastes good.