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Anti-tumor tabletted candy as preparation method and application thereof

A technology for anti-tumor effect and tableting candy, which can be applied to anti-tumor drugs, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of poor stability and easy decomposition, and achieve improved Stability, increase production, scavenge free radicals in the body

Inactive Publication Date: 2016-11-09
GUANGZHOU LIUSHUN BIO TEC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although sulforaphane and proanthocyanidin B2 have the above-mentioned effects, the stability of the two is not good and they are easy to decompose. Therefore, for the two substances of sulforaphane and proanthocyanidin B2, the present invention proposes a compressive drug with anti-tumor effect. piece of candy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Preparation of compressed candies

[0032] A compressed candy with anti-tumor effect, comprising the following components: sulforaphane powder, proanthocyanidin B2, maltodextrin, microcrystalline cellulose, magnesium stearate and xylitol, the mass between the components The ratio is 2.0:0.2:1.8:0.5:0.03:0.005.

[0033] The tableted candy is prepared through the following steps:

[0034] S10: Mix sulforaphane powder, proanthocyanidin B2, maltodextrin, microcrystalline cellulose, magnesium stearate and xylitol according to the proportion;

[0035] S11: Tablet the components mixed in step S10 to obtain tablet candy.

[0036] Wherein, in step S10, the sulforaphane powder is prepared by the following method:

[0037] S20: Mixing concentrated radish powder, concentrated broccoli powder and concentrated defatted radish powder in a mass ratio of 1:1:4 to obtain concentrated vegetable powder;

[0038] The concentrated radish powder is peeled and cut into pieces of fresh l...

Embodiment 2

[0061] 1. Preparation of compressed candies

[0062] A compressed candy with anti-tumor effect, comprising the following components: sulforaphane powder, proanthocyanidin B2, maltodextrin, microcrystalline cellulose, magnesium stearate and xylitol, the mass between the components The ratio is 2.5:0.2:2.3:0.5:0.03:0.005.

[0063] The tableted candy is prepared through the following steps:

[0064] S10: Mix sulforaphane powder, proanthocyanidin B2, maltodextrin, microcrystalline cellulose, magnesium stearate and xylitol according to the proportion;

[0065] S11: Tablet the components mixed in step S10 to obtain tablet candy.

[0066] Wherein, in step S10, the sulforaphane powder is prepared by the following method:

[0067] S20: Mixing concentrated radish powder, concentrated broccoli powder and concentrated defatted radish powder in a mass ratio of 1:1:6 to obtain concentrated vegetable powder;

[0068] The concentrated radish powder is peeled and cut into pieces of fresh l...

Embodiment 3

[0094] 1. Preparation of compressed candies

[0095] This example is similar to Example 1, the difference is that the mass ratio between the components of sulforaphane powder, proanthocyanidin B2, maltodextrin, microcrystalline cellulose, magnesium stearate and xylitol is 2.3:0.2 :2.0:0.5:0.03:0.005.

[0096] 2. Animal experiments

[0097] 1. Experimental materials

[0098] BALB / c nude mice, female, SPF grade, weighing 16-18g, Hunan Slack Jingda Experimental Animal Co., Ltd.;

[0099] HepG2 human liver cancer cells, Cell Bank of Shanghai Chinese Academy of Sciences;

[0100] Doxorubicin hydrochloride for injection, Zhejiang Hisun Pharmaceutical Co., Ltd.;

[0101] Tablet candy (stored for 24 months) in this embodiment, 500 mg / tablet.

[0102] 2. Experimental method

[0103] After HepG2 human liver cancer cells were subcultured, the cells in the logarithmic growth phase were taken and prepared into 1×10 cells with PBS. 7 The cell suspension at the concentration of cells / ...

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PUM

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Abstract

The invention relates to the technical field of foods and particularly discloses an anti-tumor tabletted candy containing raphanin and procyanidine B2 and a preparation method thereof. The tabletted candy comprises the following components: raphanin powder, procyanidine B2, maltodextrin, microcrystalline cellulose, magnesium stearate and a sweetening agent. The tabletted candy is prepared by the steps of mixing the components, and carrying out tabletting. By virtue of the synergistic effect of procyanidine B2 and raphanin, the stabilities of procyanidine B2 and raphanin are improved, and procyanidine B2 and raphanin can continuously and efficiently exert effects of resisting oxidization and clearing in-vivo free radicals respectively in a direct way and an indirect way and show a remarkable tumor inhibition effect.

Description

technical field [0001] The invention relates to the field of food technology, in particular to a compressed candy containing sulforaphane and proanthocyanidin B2 with an anti-tumor effect, a preparation method and application thereof. Background technique [0002] At present, the aggravation of air pollution, the increasing seriousness of food safety problems, and bad living habits such as smoking have led to the production of a large number of free radicals in the human body. Free radicals can oxidize lipids and damage cell membranes; interact with protein molecules to destroy the structure of normal proteins, especially various enzymes, causing them to fail to perform their normal physiological functions; interact with DNA molecules to damage genes and cause cell mutation. These adverse effects of free radicals can cause various diseases such as aging, inflammation, diabetes, cardiovascular disease and cancer, so removing free radicals in the body can effectively protect h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23G3/48A23G3/42A23G3/40A23G3/36A61K31/353A61K31/26A61K9/20A61P35/00
CPCA23G3/36A23G3/40A23G3/42A23G3/48A23G2200/06A23G2200/08A23G2200/14A23V2002/00A61K9/0056A61K9/2059A61K31/26A61K31/353A61K47/38A23V2200/30A61K2300/00
Inventor 刘兵
Owner GUANGZHOU LIUSHUN BIO TEC CO LTD
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