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Raphanin capsule capable of being stored stably and preparation method thereof

A technology of sulforaphane and capsules, which is applied in the directions of capsule delivery, medical preparations with inactive ingredients, and pharmaceutical formulations, can solve problems such as inability to eat in large quantities, and achieve the effects of easy storage, simple and easy process, and easy portability.

Active Publication Date: 2017-12-15
PIONEER HERB IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the material diethylene glycol monoethyl ether of the dropping pill that patent CN106619553A uses, monolinoleic acid glyceride and polyoxyethylene castor oil EL all belong to surfactant, form microemulsion under the effect of homogenizer and sulforaphane The sulforaphane microemulsion quick-release dropping pills made of such materials are often used as the base material of drug capsules and cannot be eaten in large quantities. If such materials are used as health food for long-term consumption, there are certain deficiencies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of sulforaphane capsules which can be stored stably, the method comprises the following steps:

[0025] (1) Add 150g of α-cyclodextrin, 50g of trehalose, and 0.2g of citric acid into 1000g of purified water, stir and heat to 90°C, dissolve to form a transparent solution, and use it as an auxiliary material for embedding sulforaphane microcapsules;

[0026] (2) After stirring and mixing 20 g of sulforaphane liquid with a purity of 80% and the auxiliary material solution, use a homogenizer to process at 8000 rpm, homogenize 3 times, each time interval is 20 minutes, and obtain a sulforaphane microemulsion;

[0027] (3) Drying the sulforaphane microemulsion through a spray drier, the inlet temperature is 140°C, and the outlet temperature is 70°C to obtain sulforaphane powdery solid particles, and the residence time of the material in the drier is about 10s;

[0028] (4) Filling powdery solid particles into capsules to a filling degree of 80% to obtain ...

Embodiment 2

[0031] A preparation method of sulforaphane capsules which can be stored stably, the method comprises the following steps:

[0032] (1) Add 160g of α-cyclodextrin, 40g of trehalose, and 0.3g of citric acid to 1000g of purified water, stir and heat to 90°C, dissolve to form a transparent solution, and use it as an auxiliary material for embedding sulforaphane microcapsules;

[0033] (2) After stirring and mixing 20 g of sulforaphane liquid with a purity of 50% and the auxiliary material solution, use a homogenizer to process at 8000 rpm, homogenize 4 times, each time interval is 15 minutes, and obtain a sulforaphane microemulsion;

[0034] (3) Drying the sulforaphane microemulsion through a spray drier, the inlet temperature is 130°C, and the outlet temperature is 60°C to obtain sulforaphane powdery solid particles, and the residence time of the material in the drier is about 10s;

[0035] (4) Filling powdery solid particles into capsules to a filling degree of 90% to obtain su...

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PUM

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Abstract

The invention relates to a preparation method of a raphanin capsule capable of being stored stably. The preparation method comprises the following steps: (1) adding water to raphanin embedded ingredients to form an ingredient solution, wherein the ingredients comprise alpha-cyclodextrin, trehalose and citric acid; (2) after mixing raphanin liquid with the ingredient solution, carrying out treatment by adopting a homogenizer to obtain a raphanin microemulsion; (3) drying the raphanin microemulsion through a spray dryer to obtain raphanin powdery solid particles; and (4) carrying out capsule filling on the powdery solid particles to obtain the raphanin capsule capable of being stored stably. Compared with the prior art, raphanin can be embedded into an annular cavity of alpha-cyclodextrin, the exterior of the cavity is closed by using sodium alga acid, and due to the fact that air, oxygen and the like are isolated, the raphanin capsule can be stored at normal temperature and can be stored at the temperature of 25 DEG C for one year, and the content of raphanin is decreased by less than 2%.

Description

technical field [0001] The invention relates to a preparation method of a natural product preparation, in particular to a sulforaphane capsule which can be stored stably and a preparation method thereof. Background technique [0002] Sulforaphane is a type of isothiocyanate with the strongest anti-cancer activity found in vegetables so far. It is currently recognized as one of the natural products with the best anti-cancer and anti-cancer effects. It is effective for liver cancer, breast cancer, and lung cancer. , esophageal cancer, prostate cancer, and gastric cancer have obvious blocking effects, and it is the inducer with the strongest ability to induce type II detoxification enzymes in nature. With the deepening of research, people found that sulforaphane can not only inhibit and kill cancer cells, but also has pharmacological effects such as antibacterial, improving the body's antioxidant capacity and immunity. Sulforaphane extracted from plants by enzymatic hydrolysis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/69A61K47/26A61K47/12A61K31/26A61P35/00A61P39/06A61P31/04A61P37/04A23L33/00A23P10/30
CPCA23V2002/00A61K9/4858A61K31/26A23L33/00A23P10/30A23V2200/302A23V2200/308A23V2200/324
Inventor 刘儒华
Owner PIONEER HERB IND CO LTD
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