32 results about "Periodontal Disorder" patented technology

The invention provides genetic markers of periodontal disorders and / or periodontal diseases. The present invention provides methods and compositions to aid in the detection, diagnosis, treatment and monitoring of periodontal disorders and / or periodontal diseases.

Disclosed are a liquid type dentifrice composition primarily containing silver particles which is drawn out in foam state when used to brush teeth to prevent the liquid dentifrice from flowing down during tooth-brushing, resulting in effective and convenient tooth-brushing function and exhibit bactericidal action and protect mouth and teeth from periodontal disease and other mouth diseases because of original properties of silver ingredients in the dentifrice composition; and, in addition to, a mousse type dentifrice formulation using the same that improves aesthetic property and product quality thereof. The inventive dentifrice composition primarily containing silver particles useful for mouthwash comprises: at least one surfactant selected from a group consisting of 0.5 to 3% by weight of SQdium lauryl sulfate, 0.05 to 1% by weight of sodium sarcosine laurate, 0.5 to 5% by weight of alkyl polyglucoside and 0.5 to 3% by weight of sucrose fatty acid ester; at least one wetting agent selected from a group consisting of 30 to 80% by weight of sorbitol solution and 0.5 to 5% by weight of glycerine; at least one solubilizing agent selected from a group consisting of 0.1 to 1% by weight of hydrogenated polyoxyethylene caster oil and 0.1 to 1% by weight of polyoxyethylene sorbitan monolaurate effective to solubilize flavor and active ingredients; 0.01 to 10% by weight of silver particles with bactericidal action; and the balance of purified water relative to total weight of the composition. The inventive mousse type dentifrice formulation comprising the above liquid dentifrice composition is prepared by steps of: introducing the dentifrice composition comprising silver particles as essential ingredient into a foam generating receptacle with constant capacity; and drawing the composition in foam form through outlet of the receptacle in order to brush teeth.

An in vitro method for assessing or predicting the response of a human patient to periodontal disease treatment is disclosed. The method is based on determining insights to biomarker proteins. Accordingly, the concentration of a specific protein combination is measured in a saliva sample of a patient. One such combination is at least one of interleukin 1 [beta] (IL1 [beta]) and matrix metalloproteinase 8 (MMP8), and [alpha] 1 acid glycoprotein (A1AGP). At least one value reflecting the combined concentration of the protein is determined based on the measured concentration. The at least one value may indicate a likelihood that the human patient has or will successfully treat periodontitis. The at least one value may be compared to at least one threshold that in the same manner reflects a combined concentration associated with successful treatment of periodontitis. The comparison allows evaluation of whether the test value is an indication of the patient's periodontal treatment status.

The invention relates to an oral mucosa medicament slow release preparation for treating oral periodontal disease, which comprises an oral mucosa contact layer and an unbonded close layer, wherein the oral mucosa contact layer comprises the components of anti-biotic medicines and accessories in weight proportion of 2-20:80-98; and the unbonded close layer comprises an unbonded low water-solubility high molecular polymer. The preparation comprises the following steps: preparing a corresponding contact layer paster and water solution through uniformly mixing the anti-biotic medicine and the accessories; coating water solution of the unbonded low water-solubility high molecular polymer on a single surface of the contact layer paster; and drying to obtain the oral mucosa medicament slow release preparation. The oral mucosa medicament slow release preparation has convenient administration, long medicament release, uniform release speed, strong target property, strong bonding property with membrane, and the like; meanwhile, the preparation method has simple operation, low cost and environment protection, and is suitable to industrialized production.

A three-in-one tooth-cleaning device structured as a toothpick, an interdental brush, and a floss pick includes a main body and an interdental elastic-bristle portion. The main body is integrally formed of a first plasticized material by injection molding and is structured as a floss pick at one end and as a toothpick at the opposite second end. The interdental elastic-bristle portion is integrally formed by injection molding a second plasticized material over the periphery of the main body in a section adjacent to the second end of the main body and forms a plurality of bristles. The second plasticized material has a lower hardness than the first plasticized material. The three-in-one tooth-cleaning device can be carried around to perform diversified, thorough, and effective removing operations on the dental plaque or food debris on and / or between teeth anytime and anywhere to prevent dental caries (especially interdental caries) and periodontal disease.

A novel peptide and a composition including the peptide are disclosed. The composition may be a pharmaceutical composition, a quasi-drug composition, a dietary supplement, or a food composition. A polynucleotide encoding the peptide and an expression vector including the polynucleotide are also disclosed. The peptide promotes regeneration of hard tissue and is useful for treating dentin-dental pulp diseases or periodontal diseases.

Disclosed is an in vitro method for assessing whether a human patient is free from periodontal disease, has gingivitis, has mild periodontitis or has advanced periodontitis. The method is based on theinsight to determine biomarker proteins. Accordingly, in a sample of saliva of a patient, the concentrations are measured of the proteins: Alpha-1-acid glycoprotein (A1AGP) and Pyruvate Kinase (PK),and at least one of the proteins Matrix metalloproteinase-9 (MMP-9) and S100 calcium binding protein A8 (S100A8). Based on the concentrations as measured, at least one value is determined reflecting the joint concentrations for said proteins. This at least one value may indicate the probability that human patient is free from periodontal disease, has gingivitis, has mild periodontitis or has advanced periodontitis. The at least one value can be compared with at least one threshold value reflecting in the same manner the joint concentrations associated with gingivitis, mild or advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the periodontal health status in said patient.

The invention relates to a preparation method of an extract for treating periodontal diseases. The invention aims to solve the problems of the prior slow release drugs for treating periodontal diseases, including drug tolerance after long-term administration, and no antihemorrhagic, analgesic and tissue regeneration effects. The inventive extract is prepared from panax notoginseng, salvia miltiorrhiza, drynaria fortunei, angelica sinensis, flos Lonicerae, radix glycyrrhizae, colla cornus cervi, Chinese insect wax, solid paraffin, liquid paraffin and water. The preparation method comprises the following steps of: (1) preparing panax notoginseng extract; (2) preparing the extract of salvia miltiorrhiza, drynaria fortunei, angelica sinensis, flos lonicerae and radix glycyrrhizae; and (3) mixing the extracts, adding the rest raw materials to obtain the extract for treating periodontal diseases. The extract for treating periodontal diseases has the advantages of no antibiotics or drug tolerance; and has tissue regeneration promoting effect.