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A kind of external preparation for oral cavity and preparation method thereof

A technology for external preparation and oral cavity, which is applied in the field of oral external preparation and its preparation, can solve problems such as poor curative effect and unsatisfactory drug release, and achieve the effects of large drug loading, good drug efficacy and fast onset of drug effect.

Active Publication Date: 2019-03-26
中国人民解放军白求恩医务士官学校
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a preparation for external use in the oral cavity and its preparation method to solve the problems of unsatisfactory drug release and poor curative effect in the existing preparations for external use in the oral cavity

Method used

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  • A kind of external preparation for oral cavity and preparation method thereof
  • A kind of external preparation for oral cavity and preparation method thereof
  • A kind of external preparation for oral cavity and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Weigh 25g of rag grass, 20g of pugengrass, 15g of keel, 8g of wild chrysanthemum, 20g of Speranthema, 7g of forsythia, 20g of Galla gall, 10g of talc, 6g of Huangdan, 2g of Lingnan pepper root, 2g of licorice, press The solid-to-liquid ratio is 1:10, mix the Chinese medicine components and soak them in water for 30 minutes, heat the soaked medicines, boil them for 1.5 hours on low heat, and filter to obtain a filtrate and filter residue; Add water to the filter residue at a solid-to-liquid ratio of 1:6, boil for 30 minutes on low heat, and filter to obtain the secondary filtrate; mix the primary filtrate and the secondary filtrate, and concentrate until the relative density is 1.10 to obtain the Chinese medicine extract ;

[0031] (2) Using cellulose ether as the solute and ethanol as the solvent, prepare an ethanol solution of cellulose ether with a mass ratio concentration of 10%, coat the film, dry it, and form the film to obtain a back layer film with a thicknes...

Embodiment 2

[0036] (1) Weigh 30g of rag grass, 15g of pugengrass, 10g of keel, 6g of wild chrysanthemum, 25g of Sperancae, 10g of forsythia, 15g of Galla chinensis, 8g of talc, 8g of Huangdan, 1g of Lingnan pepper root, 3g of licorice, press The solid-to-liquid ratio is 1:10, mix the Chinese medicine components and soak them in water for 30 minutes, heat the soaked medicines, boil them for 1.5 hours on low heat, and filter to obtain a filtrate and filter residue; Add water to the filter residue at a solid-to-liquid ratio of 1:6, boil for 30 minutes on low heat, and filter to obtain the secondary filtrate; mix the primary filtrate and the secondary filtrate, concentrate, and condense into a paste with a relative density of 1.15 to obtain Chinese herbal extracts;

[0037] (2) Using cellulose ether as the solute and ethanol as the solvent, prepare an ethanol solution of cellulose ether with a concentration of 8% by mass, coat the film, dry it, and form the film to obtain a back layer film wi...

Embodiment 3

[0042] (1) Weigh 28g of rag grass, 25g of Pugen grass, 13g of keel, 12g of wild chrysanthemum, 15g of Speranthema, 8g of forsythia, 18g of Galla gall, 9g of talc, 7g of Huangdan, 3g of Lingnan pepper root, 2g of licorice, press The solid-to-liquid ratio is 1:10, mix the Chinese medicine components and soak them in water for 30 minutes, heat the soaked medicines, boil them for 1.5 hours on low heat, and filter to obtain a filtrate and filter residue; Add water to the filter residue at a solid-to-liquid ratio of 1:6, boil for 30 minutes on low heat, and filter to obtain the secondary filtrate; mix the primary filtrate and the secondary filtrate, concentrate, and condense into a paste with a relative density of 1.2 to obtain Chinese herbal extracts;

[0043] (2) Using cellulose ether as the solute and ethanol as the solvent, prepare an ethanol solution of cellulose ether with a mass percentage concentration of 12%, coat the film, dry it, and form the film to obtain a back layer f...

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Abstract

The invention discloses an oral preparation for external use. The preparation is a composite film composed of a backing layer, a sustained-release layer, and an immediate-release layer; the backing layer is a film prepared from cellulose ether; and the sustained-release layer is A film prepared from a mixed glue composed of Chinese medicine extract, porous starch, chitosan, sodium alginate, polyvinyl alcohol, borneol, honey and purified water in a certain mass ratio; the immediate-release layer is extracted from Chinese medicine The film is prepared from a mixed glue composed of substance, porous starch, borax, carbomer, peppermint oil and purified water in a mass ratio. At the same time, the invention also discloses a preparation method of the preparation. Through the unique formula of traditional Chinese medicine extracts and the scientific design of the dosage form film layer, the present invention effectively solves the problems existing in existing oral preparations, and achieves quick effect, good sustained-release performance, and can reduce swelling and pain, remove blood stasis, and unblock meridians. It has a unique curative effect on periodontal disease, treating both the symptoms and the root causes.

Description

technical field [0001] The invention relates to the field of oral medicine, in particular to an external preparation for treating oral cavity and a preparation method thereof. Background technique [0002] Periodontal disease refers to chronic, nonspecific, infectious diseases that occur in tooth supporting tissues including gingiva, periodontal ligament, alveolar bone and cementum. According to the different parts of the disease invasion, it is mainly divided into: gingivitis and periodontitis. Gingivitis is characterized by red, swollen gums that bleed when brushing or probing. And periodontal inflammation is not only located in the gums, but also involves deeper periodontal tissues, such as the heel connective tissue, periodontal ligament and supporting alveolar bone. In addition, wisdom tooth swelling and pain are also common periodontal diseases. It is estimated that the incidence of periodontal disease in developed countries is about 50%, while that in developing co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61K9/70A61P1/02A61P29/00A61K33/12A61K35/02A61K33/24A61K35/64
CPCA61K47/36A61K9/0002A61K9/006A61K9/7046A61K33/12A61K33/24A61K35/02A61K35/63A61K36/185A61K36/287A61K36/47A61K36/484A61K36/53A61K36/634A61K36/758A61K2300/00
Inventor 张林祺李金生张涛徐彪贾向春王志玲霍江涛赵聪格刘会敏张昀马钢陈英会
Owner 中国人民解放军白求恩医务士官学校
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