50 results about "Chronic periodontitis" patented technology

The invention provides a mouthwash for treating chronic periodontitis, which includes following raw materials: radix melastoma dodecandrum, acanthopanax lasiogyne root bark, symplocos sumuntia leaves, monochasma sheareri, coptis chinensis, achyranthes bidentata, eriocaulon buergerianum, paenoy bark, white peony roots, rheum franzenbachii, achillea sibirca, aster ageratoides, cistanche deserticola, rhizoma cimicifugae, radix angelicae, smoked plum, radix scrophulariae, honeysuckles, thlaspi arvense, coix seeds and liquorice. The mouthwash is simple in preparation method, is good in compliance, is definite in curative effect, is less in side effect and is valuable to popularize.

The invention provides a probe and a primer for detecting single nucleotide polymorphism related to chronic periodontitis, and a kit thereof. The probe and the primer for detecting single nucleotide polymorphism related to chronic periodontitis disclosed by the invention comprise specific amplification primer pairs at single nucleotide polymorphic site rs2891168, specific amplification primer pairs at single nucleotide polymorphic site rs1800796, a detection probe of the single nucleotide polymorphic site rs2891168, and a detection probe of the single nucleotide polymorphic site rs1800796. A kit prepared by the probe and the primer for detecting the single nucleotide polymorphism related to the chronic periodontitis is also further provided by the invention. The probe, the primer and the kit disclosed by the invention are especially suitable for single nucleotide polymorphism research of chronic periodontitis of Chinese Han nationality population.

The invention discloses markers and a kit for implementing screening, diagnosis and therapeutic efficiency evaluation of chronic periodontitis. The invention discovers the molecular markers which arerelated to diagnosis and severe disease course classification of chronic periodontitis, wherein the molecular markers include p19mRNA, p40mRNA, p35mRNA and EBI3mRNA, as well as quantitative detectionof the molecular markers and a combination of the molecular markers. The markers, which are applicable to diagnosis of the chronic periodontitis, are expected to be used for preparing the kit for implementing screening, diagnosis and therapeutic efficiency evaluation of the chronic periodontitis.

The invention relates to a medicinal composition for treating periodontal disease and an application thereof. The medicinal composition for treating the periodontal disease is prepared from the following traditional Chinese medicinal materials in parts by mass: 28-36 parts of asarum, 28-36 parts of pagoda tree flower, 11-20 parts of rhizoma drynariae and 0.3-1 part of menthol, the raw materials are ground into powder and blended into paste by virtue of white spirit, so that the medicinal composition for treating the periodontal disease is obtained. When the medicinal composition for treating the periodontal disease is locally applied to treatment on periodontal disease like chronic periodontitis, high concentration at a periodontal local part can be rapidly realized, and pathogenic microorganisms can be directly killed or inhibited.

The invention discloses a traditional Chinese medicine preparation for treating chronic periodontitis, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 10 parts of rhizoma menispermi, 8 parts of dayflower, 8 parts of physalis permviana, 10 parts of fructus viticis, 6 parts of juncus roemerianus, 7 parts of nidus vespae, 5 parts of herba cepbalanoplosis segeti, 8 parts of glechoma hedracea, 8 parts of paniculate swallowwort root, 8 parts of radix angelicae, 8 parts of ternate buttercup root, 10 parts of Chinese olive, 6 parts of loofah sponge, 8 parts of cowherb seed, 8 parts of semen citri reticulatae, 8 parts of mulberry, 10 parts of codonopsis pilosula, 8 parts of white hyacinth bean, 12 parts of roses, 12 parts of spina date seeds and 10 parts of radix polygonati officinalis. Natural traditional Chinese medicines are adopted as raw materials, so that the traditional Chinese medicine preparation is accurate in curative effect, low in price and free of a toxic or side effect; the chronic periodontitis can be effectively cured and does not easily relapse; and the effective rate reaches 98%.

The invention relates to a method for immortalizing a human exfoliated deciduous tooth endodontium stem cell line through hTERT recombinant lentivirus. The method comprises: 1, carrying out primary culture on primary human exfoliated deciduous tooth endodontium stem cells SHED; and 2, constructing immortalized human exfoliated deciduous tooth endodontium stem cells hTERT-SHED stably expressing hTERT gene. According to the present invention, the constructed immortalized genetically engineered cells expressing the hTERT gene is adopted as the effective cell model for researching the biological characteristics of the human exfoliated deciduous tooth endodontium stem cells so as to easily and deeply research the applications of the constructed immortalized genetically engineered cells as the seed cells in the periodontal tissue engineering and the actions of different drugs on the cells and the signal transduction pathways of the related action mechanisms, and the constructed immortalized genetically engineered cells are used to screen the traditional Chinese medicine effective components for effectively treating chronic periodontitis so as to provide the powerful tool for the subsequent research of the periodontal tissue repair and reconstruction and the development of the novel effective drugs.

The invention provides application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis, and magnesium hydride toothpaste. The weight percentage of magnesium hydride in the composition or the magnesium hydride toothpaste is 1-3%. The toothpaste has the effects of sterilizing, resisting inflammation, resisting oxidation, removing tooth stains, improving breath or halitosis, relieving redness, swelling and bleeding of gingiva and gingival recession, and improving periodontitis symptoms. The invention also discloses application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis. According to the invention, a proper amount of magnesium hydride fine particles are added into the toothpaste body;and the magnesium hydride particles can be hydrolyzed into hydrogen and magnesium ions with an anti-inflammatory effect, and also can inhibit alveolar bone absorption. The composition containing magnesium hydride is safe to use, and can effectively prevent the occurrence and development of periodontal diseases after long-term use.

The invention provides a medical composition for treating oral mucosa diseases. The medical composition is prepared from the following raw material medicines in parts by weight of 5-50 parts of radixbupleuri, 3-30 parts of rhizoma cimicifugae, 8-80 parts of radix astragali, 3-30 parts of poria cocos, 3-30 parts of ginseng, 3-30 parts of radix glycyrrhizae preparata, 3-30 parts of swordlike atractylodes rhizomes, 3-30 parts of bighead atractylodes rhizomes, 3-30 parts of fructus aurantii, 3-30 parts of rhizoma coptidis, 3-30 parts of radix scutellariae, 3-30 parts of cinnamon and 5-50 parts ofherba cistanches. The invention also further discloses a preparation method and purpose of the medical composition. The traditional Chinese medicine composition provided by the invention is novel informula and simple in composition, has the advantages of being low in cost, notable in treatment effects, free from toxic and side effects and the like, tolerance is not easy to produce, and a new medication selection is provided for clinical treatment of the oral mucosa diseases of oral lichen planus, dental ulcer or chronic periodontitis and the like.

The invention discloses a pharmaceutical composition for treating chronic periodontitis and a preparation method thereof. The pharmaceutical composition is prepared from an active ingredient and pharmaceutical excipients, wherein the active ingredient is a penthorum chinense pursh extract. The preparation method comprises the following steps: performing reflux extraction of penthorum chinense pursh with 55-70% ethanol solution by volume, and filtering to obtain an alcohol extract; performing reduced-pressure concentration to dryness to obtain a crude extract; adding water for dissolution, extracting with chloroform and separating to obtain a chloroform extract; and performing reduced-pressure concentration to obtain a thick paste, and drying to obtain the penthorum chinense pursh extract. The pharmaceutical composition has a remarkable curative effect on periodontitis, reduces the recurrence rate of a patient and causes few adverse reactions.

The invention discloses a Chinese medicine preparation for treating chronic periodontitis. Traditional Chinese medical science thinks that inflammation, bleeding, red swelling and pain of gum and ozostomia are mostly caused by stomach fire flaring up, deficiency of the kidney yin and foreign invasion of fire heat, evil and toxicity. Therefore, traditional Chinese medicines such as perny false fairybells rhizome, selenitum, dendrobe, rhizoma anemarrhenae, rubiaceae randia depauperata, golden cypress, meadowrue root and rhizome, souliea vaginata, red peony root, taiwan beautyberry leaf, Indian bodhi tree bark, java speedwell and liquorice are selected in the Chinese medicine preparation disclosed by the invention and decocted for twice by a drug manufacturing room of a hospital (described in the specification) according to the traditional preparation method, filtrates are combined and taken orally, the residual leaves are added with water to be concentrated and decocted, and liquid medicine is leached for rinsing the mouth. Clinical test shows that the total effective rate is 95.6% and is obviously better than that of a control group.

The invention relates to a composition of periodontitis Chinese medicinal formulae. The composition is characterized by being prepared from, by weight, 12 g to 35 g of dried rehmannia roots, 24 g to 35 g of prepared rehmannia roots, 20 g to 35 g of radix scrophulariae, 15 g to 35 g of rhizoma drynariae, 18 g to 35 g of honeysuckle flowers, 15 g to 30 g of asarum sieboldi Mig., 20 g to 50 g of wild chrysanthemum flowers and 10 g to 18 g of rheum officinale. The medicine is scientifically prepared according to traditional Chinese pharmacopeia, the medicine is used aiming at the root cause of the focus, the composition is formed by blending multiple traditional Chinese medicines, has the effects of diminishing inflammation and removing fire, and has strange effects on acute and chronic periodontitis caused by various causes and oral cavity pain caused by inflammation.

The invention discloses an immune adjustment preparation for treating chronic periodontitis and a preparation method of the immune adjustment preparation for treating chronic periodontitis, and belongs to the technical field of periodontitis treatment medicines. The preparation comprises the following components in parts by weight of 4-10 parts of radix et rhizoma rhei, 6-12 parts of radix scutellariae, 10-16 parts of fructus forsythiae, 6-12 parts of heartleaf houttuynia herbs, 5-14 parts of honeysuckle flowers, 5-11 parts of spina gleditsiae, 6-12 parts of herba violae and 5-10 parts of licorice roots. The preparation method comprises the following steps of respectively crushing raw materials to obtain fine powder, performing uniform mixing in parts by weight, adding ethanol, performingheating and reflux extraction for 1-3 times, combining extracting solutions, performing filtration, performing concentration, removing ethanol, obtaining paste, performing crushing to obtain powder, and performing screening with a 20-mesh sieve so as to obtain the immune adjustment preparation. According to the immune adjustment preparation disclosed by the invention, the heartleaf houttuynia herbs, the honeysuckle flowers and the fructus forsythiae have the efficacy of resisting bacteria, so that the capacity of a product medicine for restraining pathogenic bacteria can be increased, and thepossibility that organisms are easily influenced by other viruses due to reduction of immunity of the organisms at the period of tooth inflammation can be reduced; and besides, the heartleaf houttuynia herbs also have the treatment effect of reinforcing the immune functions of the organisms, so that the swallowing capacity of leucocyte can be increased, and the treatment effects of the product medicine can be increased.