50 results about "Chronic periodontitis" patented technology

Protocols are provided for the use of frequency specific microcurrent in conjunction with dental or orthodontic procedures to treat or prevent inflammation induced complications. Specific protocols are disclosed for use in conjunction with gingival surgery and chronic periodontitis, implant / osseous periodontal surgery, general post operative trauma, pulpal trauma, pulpal inflammation, root canal post op, chronic osteonecrosis, osteonecrosis surgery post op, orthodontic pain prevention, and orthodontic mid-adjustment procedures.

The invention provides an oral Chinese medicine preparation for treating chronic periodontitis, which comprises the following raw medicines in parts by weight: 10-20 parts of red paeony root, 10-20 parts of indigo naturalis, 10-20 parts of Danshen roots, 10-20 parts of drynaria rhizome, 10-20 parts of pseudo-ginseng, 10-20 parts of angelica roots, 10-20 parts of notopterygium roots, 10-20 parts of suberect spatholobus stem, 10-20 parts of honeysuckle, 10-20 parts of dandelion, 10-20 parts of baical skullcap roots, 10-20 parts of golden cypress, 10-20 parts of borneol and 10-20 parts of eclipta. The oral Chinese medicine preparation has the greatest characteristic of rapidly relieving pains, can take the action of auxiliary treatment on patients subjected to dental operations, has the functions of clearing heat and detoxicating, reducing swellings and relieving the pains, removing erosion and generating muscles as well as astringing and arresting bleeding and has a good treatment effect on the periodontitis.

Protocols are provided for the use of frequency specific microcurrent in conjunction with dental or orthodontic procedures to treat or prevent inflammation induced complications. Specific protocols are disclosed for use in conjunction with gingival surgery and chronic periodontitis, implant / osseous periodontal surgery, general post operative trauma, pulpal trauma, pulpal inflammation, root canal post op, chronic osteonecrosis, osteonecrosis surgery post op, orthodontic pain prevention, and orthodontic mid-adjustment procedures.

The present invention is directed to mutants of lysine decarboxylase, nucleic acids encoding the mutants, and vaccines comprising the mutants for inhibiting and reducing the development of periodontal diseases, including gingivitis and chronic periodontitis. The vaccine composition comprises a recombinant lysine decarboxylase mutant which is based on a native version of the enzyme from E. corrodens and induces production of antibodies that inhibit the activity of the lysine decarboxylase enzyme in the oral cavity. The recombinant lysine decarboxylase mutant, in one version, comprises a mutation at residue 365 or at other locations within the active site, and in a preferred embodiment is produced from E. coli in large amounts and to form inclusion bodies. The purified inclusion bodies can then be used in the vaccine composition to induce in vivo production of antibodies that inhibit the activity of native E. corrodens lysine decarboxylase.

The present invention discloses a three-dimensional-printing-technology-based alveolar bone restoration method. A defective alveolar bone is analyzed positioned preoperatively according medical image data of a patient with moderate-severe alveolar bone defects caused by chronic periodontitis for determination of shape and size of the defective alveolar bone for establishment of a three-dimensional model, a biodegradable osteanagenesis-induction biocompatible material is selected, and the defective alveolar bone model is printed for molding by a three-dimensional biological printing technology. By accurate measuring of size and volume of an alveolar bone restoration module, bone meal addition amount calculation errors caused by human factors can be reduced; due to changes in bone meal particle formation traits, a bone defect repair form produced by an implant not only can effectively fill the defects in the bone, but also can stably improve a vertical osteanagenesis promotion material piling height, repairs part of horizontal alveolar bone absorption, and improves alveolar bone regeneration capacity; by use of rapid forming technology, alveolar bone restoration modules required for different patients can be formed, the internal porosity rate is adjustable, and the forming efficiency is high.

The invention relates to a gargle for treating children periodontitis. The gargle is prepared from the following substances in part by weight: 5 to 10 parts of heracleum, 5 to 15 parts of forsythia, 1 to 5 parts of cimicifugae foetidae, 3 to 8 parts of angelica dahurica, 0.1 to 0.5 parts of borneol, 3 to 10 parts of honeysuckle, 5 to 10 parts of liquorice, 3 to 8 parts of figwort, 5 to 10 parts of chuanxiong rhizome, 10 to 20 parts of asarum and 50 to 100 parts water. The invention also relates to a preparation method for the gargle. The gargle for treating the children periodontitis of the invention has the characteristics of low cost, easy preparation, low toxic or side effect and remarkable curative effect.

The invention provides a traditional Chinese medicine composition for treating periodontitis. Any common dose form can be prepared from prepared rehmannia root, rehmannia, spatholobus stem, human placenta, fortune's drynaria rhizome, uniflower swisscentaury root, red sage root, Chinese magnoliavine fruit, Chinese yam, curcuma tuber, milkvetch root, achyranthes root, wild chrysanthemum flower, Poria cocos, wolfberry, tree peony bark, oriental waterplantain rhizome and cassia bark by using a conventional preparation method of modern preparation technology. The invention also relates to application of the traditional Chinese medicine composition in preparation of drugs used for treating weak teeth due to sourness, feeble chewing, loosening and shifting of teeth, swelling gums, gringival hemorrhage and chronic periodontitis caused by kidney vacuity and excessive internal heat. The traditional Chinese medicine composition has the advantages of capacity of simultaneous treatment of principal and subordinate symptoms, good safety, a good curative effect, convenient usage, etc.

The invention discloses a traditional Chinese medicine compound for treating chronic periodontitis. The traditional Chinese medicine compound is prepared from fruits of black jetbead, euphorbia thymifolia, herbs of bigflower clinopodium, cotoneaster multiflorus bge. leaves, pteroxygonum giraldii damme et diels, emilia fosbergii, loveyly hemsleya roots, pink reineckea herbs, lombardy poplar bark, drymaria cordata, ancients euphorbia stems, abroma angusta, zinnia elegans Jacq., fructo-oligose, propolis, prepared salt, halite, halloysitum rubrum, cellulose, pectinase, coenzyme Q10 powder and vitamin C. The traditional Chinese medicine compound for treating chronic periodontitis is rich in raw material, rapid in curative effect, the effective rate reaches 100%, and the cure rate is 73%; the vitamin C is extracted purely naturally, safe, healthy and free of toxic or side effect, and the extraction ate is as high as 12.1%; all types of traditional Chinese medicine are extracted and purified multiple times, the yield is raised by 18.7%, and production cost is saved; the traditional Chinese medicine compound is of faint scent and slightly sweet in taste, peculiar smell of traditional Chinese medicine does not exist, a patient cannot have a sense of conflict, the compound is easy to take and can rapidly eliminate inflammation and relive pain, tonify the kidney and protect teeth, regeneration and repair of damaged tissue are promoted, and the purpose of curing periodontitis is achieved.

The invention provides a traditional Chinese medicine preparation for treating chronic periodontitis. The traditional Chinese medicine preparation comprises the medicinal raw materials including rheum officinale, dried rehmannia roots, prepared rehmannia roots, rhizoma anemarrhenae, moutan bark, Chinese angelica, dogwood, cimicifugae foetidae, achyranthes roots, fructus amomi, fructus psoraleae, pleurotus albellus, arundina graminifolia, loranthus parasiticus, cortex acanthopanacis, milfoil and rabdosia rubescens. The traditional Chinese medicine preparation integrates the effects of clearing and lowering stomach qi, treating blood, dispersing blood stasis and nourishing kidney yin and is applied to periodontitis patients having all symptoms; and the traditional Chinese medicine preparation is wider in indication, obvious in curative effect and more optimistic in market application prospect.

The invention provides a mouthwash for treating chronic periodontitis, which includes following raw materials: radix melastoma dodecandrum, acanthopanax lasiogyne root bark, symplocos sumuntia leaves, monochasma sheareri, coptis chinensis, achyranthes bidentata, eriocaulon buergerianum, paenoy bark, white peony roots, rheum franzenbachii, achillea sibirca, aster ageratoides, cistanche deserticola, rhizoma cimicifugae, radix angelicae, smoked plum, radix scrophulariae, honeysuckles, thlaspi arvense, coix seeds and liquorice. The mouthwash is simple in preparation method, is good in compliance, is definite in curative effect, is less in side effect and is valuable to popularize.

The invention provides a probe and a primer for detecting single nucleotide polymorphism related to chronic periodontitis, and a kit thereof. The probe and the primer for detecting single nucleotide polymorphism related to chronic periodontitis disclosed by the invention comprise specific amplification primer pairs at single nucleotide polymorphic site rs2891168, specific amplification primer pairs at single nucleotide polymorphic site rs1800796, a detection probe of the single nucleotide polymorphic site rs2891168, and a detection probe of the single nucleotide polymorphic site rs1800796. A kit prepared by the probe and the primer for detecting the single nucleotide polymorphism related to the chronic periodontitis is also further provided by the invention. The probe, the primer and the kit disclosed by the invention are especially suitable for single nucleotide polymorphism research of chronic periodontitis of Chinese Han nationality population.

The invention discloses markers and a kit for implementing screening, diagnosis and therapeutic efficiency evaluation of chronic periodontitis. The invention discovers the molecular markers which arerelated to diagnosis and severe disease course classification of chronic periodontitis, wherein the molecular markers include p19mRNA, p40mRNA, p35mRNA and EBI3mRNA, as well as quantitative detectionof the molecular markers and a combination of the molecular markers. The markers, which are applicable to diagnosis of the chronic periodontitis, are expected to be used for preparing the kit for implementing screening, diagnosis and therapeutic efficiency evaluation of the chronic periodontitis.

The invention relates to a medicinal composition for treating periodontal disease and an application thereof. The medicinal composition for treating the periodontal disease is prepared from the following traditional Chinese medicinal materials in parts by mass: 28-36 parts of asarum, 28-36 parts of pagoda tree flower, 11-20 parts of rhizoma drynariae and 0.3-1 part of menthol, the raw materials are ground into powder and blended into paste by virtue of white spirit, so that the medicinal composition for treating the periodontal disease is obtained. When the medicinal composition for treating the periodontal disease is locally applied to treatment on periodontal disease like chronic periodontitis, high concentration at a periodontal local part can be rapidly realized, and pathogenic microorganisms can be directly killed or inhibited.

The invention discloses a traditional Chinese medicine preparation for treating chronic periodontitis, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 10 parts of rhizoma menispermi, 8 parts of dayflower, 8 parts of physalis permviana, 10 parts of fructus viticis, 6 parts of juncus roemerianus, 7 parts of nidus vespae, 5 parts of herba cepbalanoplosis segeti, 8 parts of glechoma hedracea, 8 parts of paniculate swallowwort root, 8 parts of radix angelicae, 8 parts of ternate buttercup root, 10 parts of Chinese olive, 6 parts of loofah sponge, 8 parts of cowherb seed, 8 parts of semen citri reticulatae, 8 parts of mulberry, 10 parts of codonopsis pilosula, 8 parts of white hyacinth bean, 12 parts of roses, 12 parts of spina date seeds and 10 parts of radix polygonati officinalis. Natural traditional Chinese medicines are adopted as raw materials, so that the traditional Chinese medicine preparation is accurate in curative effect, low in price and free of a toxic or side effect; the chronic periodontitis can be effectively cured and does not easily relapse; and the effective rate reaches 98%.

The invention relates to a method for immortalizing a human exfoliated deciduous tooth endodontium stem cell line through hTERT recombinant lentivirus. The method comprises: 1, carrying out primary culture on primary human exfoliated deciduous tooth endodontium stem cells SHED; and 2, constructing immortalized human exfoliated deciduous tooth endodontium stem cells hTERT-SHED stably expressing hTERT gene. According to the present invention, the constructed immortalized genetically engineered cells expressing the hTERT gene is adopted as the effective cell model for researching the biological characteristics of the human exfoliated deciduous tooth endodontium stem cells so as to easily and deeply research the applications of the constructed immortalized genetically engineered cells as the seed cells in the periodontal tissue engineering and the actions of different drugs on the cells and the signal transduction pathways of the related action mechanisms, and the constructed immortalized genetically engineered cells are used to screen the traditional Chinese medicine effective components for effectively treating chronic periodontitis so as to provide the powerful tool for the subsequent research of the periodontal tissue repair and reconstruction and the development of the novel effective drugs.

The invention provides application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis, and magnesium hydride toothpaste. The weight percentage of magnesium hydride in the composition or the magnesium hydride toothpaste is 1-3%. The toothpaste has the effects of sterilizing, resisting inflammation, resisting oxidation, removing tooth stains, improving breath or halitosis, relieving redness, swelling and bleeding of gingiva and gingival recession, and improving periodontitis symptoms. The invention also discloses application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis. According to the invention, a proper amount of magnesium hydride fine particles are added into the toothpaste body;and the magnesium hydride particles can be hydrolyzed into hydrogen and magnesium ions with an anti-inflammatory effect, and also can inhibit alveolar bone absorption. The composition containing magnesium hydride is safe to use, and can effectively prevent the occurrence and development of periodontal diseases after long-term use.

The invention provides a medical composition for treating oral mucosa diseases. The medical composition is prepared from the following raw material medicines in parts by weight of 5-50 parts of radixbupleuri, 3-30 parts of rhizoma cimicifugae, 8-80 parts of radix astragali, 3-30 parts of poria cocos, 3-30 parts of ginseng, 3-30 parts of radix glycyrrhizae preparata, 3-30 parts of swordlike atractylodes rhizomes, 3-30 parts of bighead atractylodes rhizomes, 3-30 parts of fructus aurantii, 3-30 parts of rhizoma coptidis, 3-30 parts of radix scutellariae, 3-30 parts of cinnamon and 5-50 parts ofherba cistanches. The invention also further discloses a preparation method and purpose of the medical composition. The traditional Chinese medicine composition provided by the invention is novel informula and simple in composition, has the advantages of being low in cost, notable in treatment effects, free from toxic and side effects and the like, tolerance is not easy to produce, and a new medication selection is provided for clinical treatment of the oral mucosa diseases of oral lichen planus, dental ulcer or chronic periodontitis and the like.

The invention discloses a pharmaceutical composition for treating chronic periodontitis and a preparation method thereof. The pharmaceutical composition is prepared from an active ingredient and pharmaceutical excipients, wherein the active ingredient is a penthorum chinense pursh extract. The preparation method comprises the following steps: performing reflux extraction of penthorum chinense pursh with 55-70% ethanol solution by volume, and filtering to obtain an alcohol extract; performing reduced-pressure concentration to dryness to obtain a crude extract; adding water for dissolution, extracting with chloroform and separating to obtain a chloroform extract; and performing reduced-pressure concentration to obtain a thick paste, and drying to obtain the penthorum chinense pursh extract. The pharmaceutical composition has a remarkable curative effect on periodontitis, reduces the recurrence rate of a patient and causes few adverse reactions.

The invention provides a traditional Chinese medicine preparation for treating chronic periodontitis. Bone fat, white pleurotus, bamboo leaf orchid, mulberry, acanthus bark, yarrow and winter grass. It also has the effects of clearing and lowering stomach qi, treating blood and removing blood stasis, and nourishing kidney yin. It is suitable for all types of periodontitis patients. It has wider indications, significant curative effect, and a more optimistic market application prospect.

The invention is a new method for predicting when subjects having chronic periodontitis will fail or succeed conventional standard therapy. The method uses measures of the plaque cadaverine fraction with additional measurements including age, fraction of gingival margins that bleed on probing (BOP), and clinical attachment level (CAL in mm) to calculate discriminant function equations for calculating individual score sets. When CF is above 0.45 in periodontitis patients, it is predicted that most available therapies with which the periodontitis patient can be treated will fail, including a conventional standard treatment or an aggressive combined antibiotic / oral hygiene therapy.

The invention discloses a Chinese medicine preparation for treating chronic periodontitis. Traditional Chinese medical science thinks that inflammation, bleeding, red swelling and pain of gum and ozostomia are mostly caused by stomach fire flaring up, deficiency of the kidney yin and foreign invasion of fire heat, evil and toxicity. Therefore, traditional Chinese medicines such as perny false fairybells rhizome, selenitum, dendrobe, rhizoma anemarrhenae, rubiaceae randia depauperata, golden cypress, meadowrue root and rhizome, souliea vaginata, red peony root, taiwan beautyberry leaf, Indian bodhi tree bark, java speedwell and liquorice are selected in the Chinese medicine preparation disclosed by the invention and decocted for twice by a drug manufacturing room of a hospital (described in the specification) according to the traditional preparation method, filtrates are combined and taken orally, the residual leaves are added with water to be concentrated and decocted, and liquid medicine is leached for rinsing the mouth. Clinical test shows that the total effective rate is 95.6% and is obviously better than that of a control group.

The invention provides black tea added with traditional Chinese medicinal herbs for treating a chronic periodontitis disease. The black tea is prepared from the following raw materials in parts by weight: 800-1000 parts of fresh tea leaves and traditional Chinese medicinal herbs for treating the chronic periodontitis disease, wherein the traditional Chinese medicinal herbs include 40-60 parts of coptis chinensis, 30-50 parts of pipewort, 40-60 parts of herba schizonepetae, 40-50 parts of cornus pulp, 40-60 parts of dandelion and 30-45 parts of fructus schizandrae. The traditional Chinese medicinal herbs for treating the chronic periodontitis disease are added into black tea by a unique process, so that the black tea has an effect of preventing and treating the chronic periodontitis disease. By three times of black tea fermentation processes at different temperatures, aromatic alcohol, geraniol, benzyl alcohol, alpha-phenethyl alcohol, ester of cis-3-vinyl alcohol, methyl salicylate and other substances emitting fragrant smell can be furthest maintained, and the harmful germs, trans-2-hexenal and other substances harmful to human bodies can be reduced.

The invention provides research on factors such as OSM, tPA, PAI-2 and CRP in bodies of periodontal disease with coronary heart disease of Gannan Tibetan population in Gansu Province, and belongs to the technical field of coronary heart disease treatment and prevention. By researching changes of endothelial functions, proinflammatory factor levels and blood lipid indexes of patients suffering from periodontitis with coronary heart disease in Gannan Tibetan areas before and after periodontal treatment, the invention discovers that periodontal treatment can reduce the proinflammatory factor levels and cardiovascular risk marker levels of the patients suffering from moderate and severe periodontitis with coronary heart disease, and is beneficial to prevention of coronary heart disease; and moreover, chronic periodontitis may be a dangerous factor for occurrence and development of coronary heart disease. The invention provides a reference basis for formulation and implementation of prevention and treatment strategies of coronary heart disease.

The invention relates to a pharmaceutical composition for treating periodontal disease and its application. The pharmaceutical composition is made of the following Chinese herbal medicine raw materials which are ground into powder and made into a paste with white wine: Asarum 28-36 parts, Sophora japonica 28‑36 parts of flowers, 11‑20 parts of drynaria and 0.3‑1 part of menthol. The medicine of the present invention is locally applied to the treatment of periodontal diseases such as chronic periodontitis, and can rapidly reach a relatively high concentration in the local periodontal area to directly kill or inhibit pathogenic microorganisms.

The invention discloses a preparation method of a yolk antibody for preventing chronic periodontitis. The ultrasonic fragmented porphyromonas gingivalis, tannerella forsythia and campylobacter rectusare mixed uniformly to prepare a composite antigen, and the laying hen is subjected to primary immunization and booster immunization for 6 rounds to collect eggs, and the specific yolk antibody is isolated and purified. The obtained yolk antibody has high titer and good immune effect, and can effectively inhibit the growth of porphyromonas gingivalis, tannerella forsythia and campylobacter rectus,has obvious effects on the treatment and prevention of chronic periodontitis, does not affect the growth of other oral unrelated flora, and is safe and harmless.

The invention relates to a composition of periodontitis Chinese medicinal formulae. The composition is characterized by being prepared from, by weight, 12 g to 35 g of dried rehmannia roots, 24 g to 35 g of prepared rehmannia roots, 20 g to 35 g of radix scrophulariae, 15 g to 35 g of rhizoma drynariae, 18 g to 35 g of honeysuckle flowers, 15 g to 30 g of asarum sieboldi Mig., 20 g to 50 g of wild chrysanthemum flowers and 10 g to 18 g of rheum officinale. The medicine is scientifically prepared according to traditional Chinese pharmacopeia, the medicine is used aiming at the root cause of the focus, the composition is formed by blending multiple traditional Chinese medicines, has the effects of diminishing inflammation and removing fire, and has strange effects on acute and chronic periodontitis caused by various causes and oral cavity pain caused by inflammation.

The invention provides a film-like bioremediation material for periodontal tissue regeneration. The invention is characterized in that: periodontal membrane acellular matrix particles are mixed with a biodegradable polymer or high polymer material, then electrospinning is carried out to obtain a biodegradable electrospinning fibrous membrane. The invention provides the basis and a new way for improving the prognosis effect of periodontitis patients' comprehensive treatment, thereby providing an effective means and method for controlling systemic diseases (like cardiovascular diseases, diabetes, pulmonary infection and the like) caused or aggravated by chronic periodontitis and improving the health level of the whole population, and is conducive to enhancing the utility and social value of the whole oral public health system.

The invention discloses an immune adjustment preparation for treating chronic periodontitis and a preparation method of the immune adjustment preparation for treating chronic periodontitis, and belongs to the technical field of periodontitis treatment medicines. The preparation comprises the following components in parts by weight of 4-10 parts of radix et rhizoma rhei, 6-12 parts of radix scutellariae, 10-16 parts of fructus forsythiae, 6-12 parts of heartleaf houttuynia herbs, 5-14 parts of honeysuckle flowers, 5-11 parts of spina gleditsiae, 6-12 parts of herba violae and 5-10 parts of licorice roots. The preparation method comprises the following steps of respectively crushing raw materials to obtain fine powder, performing uniform mixing in parts by weight, adding ethanol, performingheating and reflux extraction for 1-3 times, combining extracting solutions, performing filtration, performing concentration, removing ethanol, obtaining paste, performing crushing to obtain powder, and performing screening with a 20-mesh sieve so as to obtain the immune adjustment preparation. According to the immune adjustment preparation disclosed by the invention, the heartleaf houttuynia herbs, the honeysuckle flowers and the fructus forsythiae have the efficacy of resisting bacteria, so that the capacity of a product medicine for restraining pathogenic bacteria can be increased, and thepossibility that organisms are easily influenced by other viruses due to reduction of immunity of the organisms at the period of tooth inflammation can be reduced; and besides, the heartleaf houttuynia herbs also have the treatment effect of reinforcing the immune functions of the organisms, so that the swallowing capacity of leucocyte can be increased, and the treatment effects of the product medicine can be increased.