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A membrane-like bioremediation material for periodontal tissue regeneration

A periodontal tissue regeneration and bioremediation technology, applied in tissue regeneration, non-woven fabrics, textiles and papermaking, etc., can solve the problems affecting clinical application prospects, poor hydrophilicity and biocompatibility, and difficulty in cell migration. To achieve the effect of completely harmless degradation products and good biodegradation performance

Active Publication Date: 2020-09-08
上海市口腔病防治院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its hydrophilicity and biocompatibility are slightly poor, and it is difficult for cells to migrate into the material, which affects the prospect of clinical application.

Method used

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  • A membrane-like bioremediation material for periodontal tissue regeneration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Such as figure 1 As shown, in this example, in order to facilitate periodontal tissue repair and periodontal tissue regeneration, a bioprosthetic material for periodontal tissue regeneration was constructed. The specific construction method is as follows:

[0042] Step 1. Obtain periodontal ligament acellular matrix particles:

[0043] (1) periodontal ligament cells are taken out from the teeth obtained during treatment;

[0044] (2) Using cell in vitro expansion technology, by adding an appropriate amount of VitC (AA) to the cell culture medium, a cell membrane rich in extracellular matrix is ​​formed;

[0045] (3) Using the decellularization technique, the cell membrane is prepared to form a periodontal ligament decellularized matrix sheet;

[0046] (4) The periodontal ligament decellularized matrix thin slices were digested with enzymes to form periodontal ligament decellularized matrix particles.

[0047] Collect healthy premolars that need to be extracted due to ...

Embodiment 2

[0054] In this example, in order to facilitate periodontal tissue repair and periodontal tissue regeneration, a bioprosthetic material for periodontal tissue regeneration was constructed. The specific construction method is as follows:

[0055] Step 1. Obtain periodontal ligament acellular matrix particles:

[0056] (1) periodontal ligament cells are taken out from the teeth obtained during treatment;

[0057] (2) Using cell in vitro expansion technology, by adding an appropriate amount of VitC (AA) to the cell culture medium, a cell membrane rich in extracellular matrix is ​​formed;

[0058] (3) Using the decellularization technique, the cell membrane is prepared to form a periodontal ligament decellularized matrix sheet;

[0059] (4) The periodontal ligament decellularized matrix thin slices were digested with enzymes to form periodontal ligament decellularized matrix particles.

[0060] Collect healthy premolars that need to be extracted due to orthodontics, use a scalpel...

Embodiment 3

[0067] In this example, in order to facilitate periodontal tissue repair and periodontal tissue regeneration, a bioprosthetic material for periodontal tissue regeneration was constructed. The specific construction method is as follows:

[0068] Step 1. Obtain periodontal ligament acellular matrix particles:

[0069] (1) periodontal ligament cells are taken out from the teeth obtained during treatment;

[0070] (2) Using cell in vitro expansion technology, by adding an appropriate amount of VitC (AA) to the cell culture medium, a cell membrane rich in extracellular matrix is ​​formed;

[0071] (3) Using the decellularization technique, the cell membrane is prepared to form a periodontal ligament decellularized matrix sheet;

[0072] (4) The periodontal ligament decellularized matrix thin slices were digested with enzymes to form periodontal ligament decellularized matrix particles.

[0073] Collect healthy premolars that need to be extracted due to orthodontics, use a scalpel...

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Abstract

The invention provides a film-like bioremediation material for periodontal tissue regeneration. The invention is characterized in that: periodontal membrane acellular matrix particles are mixed with a biodegradable polymer or high polymer material, then electrospinning is carried out to obtain a biodegradable electrospinning fibrous membrane. The invention provides the basis and a new way for improving the prognosis effect of periodontitis patients' comprehensive treatment, thereby providing an effective means and method for controlling systemic diseases (like cardiovascular diseases, diabetes, pulmonary infection and the like) caused or aggravated by chronic periodontitis and improving the health level of the whole population, and is conducive to enhancing the utility and social value of the whole oral public health system.

Description

technical field [0001] The invention relates to the technical field of biological tissue engineering scaffolds, in particular to a membrane-like biological repair material used for periodontal tissue regeneration. Background technique [0002] Chronic periodontitis can lead to gingival inflammation, periodontal tissue destruction, alveolar bone loss, and even tooth loss. It is one of the most important factors causing tooth loss in healthy people. According to the figures released by the third national oral epidemiological survey in 2005, the total prevalence rate of untreated periodontal disease was 69.0% at the age of 12, and 97.2% at the age of 35-44. The total prevalence of gum and periodontal disease in the age group of 67 to 74 is as high as 99.4%, and the survey shows that the proportion of gum bleeding in the adult population is as high as 77.3%. [0003] Periodontal disease is not only the primary cause of tooth loss in adults, but also an important cause of affect...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/38A61L27/18D04H1/728
CPCA61L27/18A61L27/3804A61L27/3865A61L27/58A61L2430/40D04H1/728C08L67/04
Inventor 赵丙姣刘月华
Owner 上海市口腔病防治院
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