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Pharmaceutical composition for treating chronic periodontitis and preparation method thereof

A technology for chronic periodontitis and a composition is applied in the field of pharmaceutical compositions for the treatment of chronic periodontitis and the preparation thereof, and achieves the effects of broad application prospects, significant curative effect and few adverse reactions

Inactive Publication Date: 2015-04-08
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report that the extract of C. chinensis has the biological activity of treating periodontitis

Method used

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  • Pharmaceutical composition for treating chronic periodontitis and preparation method thereof
  • Pharmaceutical composition for treating chronic periodontitis and preparation method thereof
  • Pharmaceutical composition for treating chronic periodontitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 chasing yellow grass extract

[0015] Clean and dry 792g of the dry product of C. chinensis, place in an extraction device with a round bottom flask, use 8L volume concentration of 60% ethanol solution for reflux extraction for 3h, filter with four layers of gauze to obtain the alcohol extract, repeat 2 times, Combine the alcohol extracts, concentrate to dryness under reduced pressure to obtain a crude extract, add 500 mL of purified water and stir to dissolve, extract three times with an equal volume of chloroform, separate and obtain the chloroform extract, recover the solvent under reduced pressure and concentrate to a thick paste, dry in a drying oven dried, crushed into fine powder, and passed through a 100-mesh sieve to obtain the extract of C.

Embodiment 2

[0016] The preparation of embodiment 2 sustained-release drug film

[0017]

[0018] Preparation method: Weigh the fine powder of the extract of C. chinensis prepared in Example 1, dissolve it in an appropriate amount of 95% ethanol solution, and use it as a medicinal liquid for later use; weigh the prescribed amount of polyvinyl alcohol and chitosan, mix well, add 300ml of water to soak , heat to dissolve, add the prepared medicinal solution of C. chinensis extract, and add glycerin and Tween-80, stir well, dry, sterilize with ultraviolet light for 30 minutes, and open the film.

Embodiment 3

[0019] Example 3 Efficacy of Herb Crush Extract on Chronic Periodontitis

[0020] There were 52 patients with chronic periodontitis who met the diagnostic criteria of periodontitis, including 29 males and 23 females; aged 25-67 years, with an average age of (39.2±5.3) years. They were randomly divided into a test group (26 cases) and a control group (26 cases). There was no significant difference in age, sex and other data between the two groups, and they were comparable. The periodontium of the two groups was rinsed with sodium chloride solution and treated with moisture barrier. The patients in the control group were treated with iodine glycerin (Xiamen Meishang Pharmaceutical Co., Ltd., H35021l17), 20g / time, once every two days; Insert into the periodontal pocket, 1 tablet / time, once every two days. After 2 weeks of treatment, the treatment results of the two groups were observed, and the curative effects were counted according to the following standards:

[0021] Signif...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating chronic periodontitis and a preparation method thereof. The pharmaceutical composition is prepared from an active ingredient and pharmaceutical excipients, wherein the active ingredient is a penthorum chinense pursh extract. The preparation method comprises the following steps: performing reflux extraction of penthorum chinense pursh with 55-70% ethanol solution by volume, and filtering to obtain an alcohol extract; performing reduced-pressure concentration to dryness to obtain a crude extract; adding water for dissolution, extracting with chloroform and separating to obtain a chloroform extract; and performing reduced-pressure concentration to obtain a thick paste, and drying to obtain the penthorum chinense pursh extract. The pharmaceutical composition has a remarkable curative effect on periodontitis, reduces the recurrence rate of a patient and causes few adverse reactions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and in particular relates to a pharmaceutical composition for treating chronic periodontitis and a preparation method thereof. Background technique [0002] Periodontitis is a chronic inflammatory and destructive disease that easily affects the patient's gums and periodontal supporting tissues, leading to tooth loss. The pathogenesis of chronic periodontitis is an oral disease caused by chronic infection of periodontal support tissue caused by microorganisms in dental plaque. Microorganisms and metabolites in dental plaque continue to act on the gums, periodontal ligament, cementum and alveolar bone, which may cause certain irreversible damage, affecting the masticatory function and oral hygiene of patients. [0003] At present, the treatment of periodontitis mainly uses antibacterial drugs to inhibit the growth of bacteria in the periodontal tissue and around the...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/02
CPCA61K36/185A61K9/7007A61K2236/333A61K2236/55
Inventor 宋玲刘海蓉张春艳吴鸿
Owner QINGDAO MUNICIPAL HOSPITAL
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