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Periodontal disease diagnostic methods, uses and kits

A periodontal disease, periodontitis technology, applied in the field of saliva-based diagnosis, can solve the problems that consumers cannot perform

Pending Publication Date: 2020-09-04
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the available methods for performing such an assessment involve a labor-intensive process, i.e., it is not routinely performed by dentists on each patient and / or visit, nor is it available to consumers (self-diagnosis). process

Method used

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  • Periodontal disease diagnostic methods, uses and kits
  • Periodontal disease diagnostic methods, uses and kits
  • Periodontal disease diagnostic methods, uses and kits

Examples

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Embodiment Construction

[0027]In a general sense, the present invention is based on the sensible insight that, in saliva samples of human patients, three rare proteins can be used as biomarkers for classifying a patient's periodontal disease state into one of the following four categories One: The first category is no periodontal disease; the second category is gingivitis; the third category is mild periodontitis or moderate periodontitis (unless otherwise specified, the term "mild periodontitis" is used here Moderate periodontitis should be included before and after, but severe periodontitis should not be included); and the fourth category is severe periodontitis.

[0028] Hereinafter, the third category is collectively referred to as mild periodontitis.

[0029] Thus, the invention can distinguish between: a healthy mouth, which does not require treatment for periodontal disease; gingivitis, which allows timely intervention to reverse the effects of periodontitis before it develops; mild periodonti...

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Abstract

Disclosed is an in vitro method for assessing whether a human patient is free from periodontal disease, has gingivitis, has mild periodontitis or has advanced periodontitis. The method is based on theinsight to determine biomarker proteins. Accordingly, in a sample of saliva of a patient, the concentrations are measured of the proteins: Alpha-1-acid glycoprotein (A1AGP) and Pyruvate Kinase (PK),and at least one of the proteins Matrix metalloproteinase-9 (MMP-9) and S100 calcium binding protein A8 (S100A8). Based on the concentrations as measured, at least one value is determined reflecting the joint concentrations for said proteins. This at least one value may indicate the probability that human patient is free from periodontal disease, has gingivitis, has mild periodontitis or has advanced periodontitis. The at least one value can be compared with at least one threshold value reflecting in the same manner the joint concentrations associated with gingivitis, mild or advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the periodontal health status in said patient.

Description

technical field [0001] The present invention is in the field of oral care and relates to saliva-based diagnosis of periodontal disease. In particular, the present invention relates to kits, uses and methods for differentiating between the states of healthy gums, gingivitis, mild periodontitis and severe periodontitis. Background technique [0002] Inflammation of the gums or gingivitis is a non-destructive periodontal disease mainly caused by the adhesion of dental bacterial film or plaque to the tooth surface. If not detected and treated, reversible gingivitis usually results in inflammation of the tissues surrounding the teeth (i.e., the periodontium), a condition defined as periodontitis, which is irreversible and leads to tissue destruction and alveolar Loss of bone, eventually leading to tooth loss. During the progression of gum disease, there are often clinical signs and symptoms associated with it, such as gum swelling, changing color from pink to dark red, bleeding...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/18G01N2800/50G01N2333/4727G01N2333/4728G01N2333/91215G01N2333/96486
Inventor G·库伊杰曼A·H·耳麦勒C·格拉斯M·K·J·德加格I·L·C·察柏尔M·M·格兰特M·A·范哈特斯卡姆普P·普雷肖J·J·泰勒
Owner KONINKLJIJKE PHILIPS NV
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