The present invention provides methods of reducing cutaneous scar formation by treating a
cutaneous wound with a composition comprising a therapeutic agent that is a
sodium channel blocker and / or an inhibitor of the Nax / SCN7A pathway. The present invention also provides wound cover components impregnated with such compositions, kits composed of such compositions with a
wound dressing or sterile wipe, and mixtures of such compositions with a topical component (e.g., cream, ointment, or gel) suitable for application to a
cutaneous wound. The present invention also provides compositions, kits, devices, and methods for treating
skin conditions (e.g., dermatitis,
psoriasis, or other
skin conditions) with such compositions and devices. Examples of such therapeutic agents include, but are not limited to, an inhibitor of a
gene or
protein selected from: ENac, COX-2, PGE2, PI3K, PKB, Nax Prss8, IL-1β, IL-8, SAPK, Erk
gene, p38
gene, PAR2, S100A8, S100A9, S100A12.