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Periodontal disease detection kit and use method

A detection kit and a technology for periodontal disease, which are applied to measurement devices, analysis by chemical reaction of materials, and material analysis by observing the influence of chemical indicators, etc., can solve the problem of late discovery of diseases and insufficient judgment of disease conditions. Objective doubts, uncontrollable issues, etc.

Inactive Publication Date: 2020-04-07
陈洁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing examination methods for periodontal disease include the following defects: it is mainly judged by doctors, and doctors have different degrees of experience in diagnosis and treatment, subjective factors cannot be ruled out, and there are still doubts that the judgment of the disease is not objective enough; the existing detection methods for gingivitis The disadvantage is that doctors can only diagnose through clinical symptoms, which leads to late detection of the disease; there is no mature technology and indicators to judge whether periodontitis is in the advanced stage, so periodontitis often misses the best time to control it, causing it to deteriorate to the point where it is impossible degree of control

Method used

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  • Periodontal disease detection kit and use method
  • Periodontal disease detection kit and use method
  • Periodontal disease detection kit and use method

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no. 1 example

[0036] A preferred embodiment of the present invention is to provide a detection kit for periodontal disease, which includes: IL-1β specific antibody, IL-18 specific antibody and at least one solid phase carrier. The ELISA method detects IL-1β and IL-18 in biological samples for the diagnosis of periodontal diseases (preferably gingivitis and periodontitis), and correspondingly determines the degree of progression or control of the disease.

[0037] Specifically, according to this embodiment, the IL-1β-specific antibody in the kit is immobilized on a solid-phase carrier, and the IL-18-specific antibody is separately immobilized on a solid-phase carrier with different particle sizes for use in Identify and capture two cytokines, IL-1β and IL-18, in biological samples for subsequent detection. Preferably, the IL-1β-specific antibody and the IL-18-specific antibody of the present invention are covalently linked to a solid-phase carrier; and the solid-phase carrier is preferably m...

no. 2 example

[0077] Another preferred embodiment of the present invention is to provide a detection kit for periodontal disease, which includes: IL-1β specific antibody, IL-18 specific antibody and at least one solid-phase carrier, through the immunochromatography-based The method used to detect IL-1β and IL-18 in biological samples is used to diagnose periodontal diseases (preferably gingivitis and periodontitis), and correspondingly determine the degree of progress or control of the disease.

[0078] Specifically, according to this embodiment, the IL-1β-specific antibody and the IL-18-specific antibody in the kit, the IL-1β-specific antibody is immobilized on a solid phase carrier, and the IL-18-specific antibody is immobilized on Different locations on the same solid support. Among them, the solid phase support is preferably a nitrocellulose membrane. With regard to the selection of immobilization positions, the two specific antibodies can be immobilized on different positions of the s...

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Abstract

The invention relates to a periodontal disease detection kit and a use method thereof, which can detect interleukin-1beta and interleukin-18 in saliva through an immunological method to judge periodontal related diseases and distinguish the morbidity progress and the treatment effect of periodontal surface soft tissue and hard tissue inflammation (namely gingivitis and periodontitis). According tothe kit and the detection method which are simple to operate and easy to distinguish, the progress degree of periodontal tissue related inflammation can be recognized by using a scientific method ina breakthrough manner, accurate objective evidences are provided for clinic, and the application benefit of self-inspection prevention of periodontal diseases is expanded.

Description

technical field [0001] The invention relates to a kit in the field of biological detection, in particular to a kit for detecting periodontal disease and a method for using the same. Background technique [0002] At present, the clinical examination method for periodontal disease in dentistry is based on the physician's comprehensive clinical symptoms, oral probing and periodontal tissue examination (such as bleeding, bad breath, swollen gum appearance, determination of plaque adhesion status, periodontal pocket depth, Bleeding or tooth looseness) and X-ray images and other results, for the evaluation and diagnosis of periodontal disease, it is necessary to observe and judge the disease from the pathological type. [0003] The early symptoms of periodontal disease are usually not obvious. Among them, gingivitis is the early stage of periodontitis. Patients often do not consciously or often ignore the initial gingivitis. Seriously, some patients even take anti-inflammatory dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N33/558
CPCG01N21/78G01N33/558
Inventor 不公告发明人
Owner 陈洁
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