53 results about "Hydroxypropylmethylcellulose phthalate" patented technology

A preparation which can improve solubility of a NPYY5 receptor antagonist in water, even when the NPYY5 receptor antagonist is contained in the preparation at a high content is provided. A solid preparation containing a NPYY5 receptor antagonist, an amorphous stabilizer, and optionally an amorphousization inducing agent. Particularly, when the amorphous stabilizer is hydroxypropylmethylcellulose phthalate and / or hydroxypropylmethylcellulose acetate succinate, and the amorphousization inducing agent is urea and / or saccharine sodium at an addition amount of less than 8% by weight, dissolution out property of a water-hardly soluble NPYY5 receptor antagonist could be improved.

A hemostatic device comprising (i) a carrier comprising at least one component selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, cellulose acetate phthalate; polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers or combinations thereof; and (ii) thrombin.

An enteric coating for a solid pharmaceutical carrier or substrate wherein the enteric coating includes a cellulosic polymeric material selected from selected from the group consisting of hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, ethyl cellulose, cellulose acetate, cellulose acetate butyrate, cellulose acetate phthalate, cellulose acetate succinate, cellulose acetate propionate, cellulose acetate trimellitate, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose succinate, hydroxypropylmethyl cellulose acetate succinate, cellulose acetate succinate butyrate, cellulose acetate succinate propionate, carboxymethylcellulose sodium, cellulose butyrate, and mixtures thereof and a plasticizer selected from a water-soluble preparation of a fat-soluble vitamin. A preferred plasticizer is Vitamin E polyethylene glycol 1000 succinate.

A duloxetine pellet formulation comprises: (i) a core including a desired amount of duloxetine; (ii) an enteric coating comprising hydroxypropylmethylcellulose phthalate (HPMCP) as an enteric polymer;and, optionally, (iii) a separating layer located between the core and the enteric coating, the separating layer including polyvinyl alcohol and a low molecular weight hydroxypropylmethylcellulose (HPMC).

The invention belongs to the field of auxiliary materials of medicines, particularly relates to a preparation method of hydroxypropyl methyl cellulose phthalate, and aims to provide the preparation method for the hydroxypropyl methyl cellulose phthalate, wherein the hydroxypropyl methyl cellulose phthalate prepared according to preparation method is higher in phthalic acyl content. The preparation method disclosed by the invention is characterized in that the reaction temperature is raised to 85-100 DEG C, the internal pressure of a reaction container is maintained to 0.3-0.9MPa, and the reacting time is 3.5-6 h. For the preparation method disclosed by the invention, the aim of promoting a positive reaction is achieved by adjusting the reaction temperature and reaction pressure, and the phthalic acyl content of a product can be increased to 25% from 21%. The preparation method disclosed by the invention has the advantages that the synthetic technology is simple, and the reaction condition is easy to control, so that the preparation method is suitable for expanding the production.

The invention discloses a premix for piglets. The premix for the piglets comprises the following raw materials in parts by weight: 15-20 parts of soybean peptide protein, 10-15 parts of a cortex eucommiae extract, 20-25 parts of an acidifying agent, 60-65 parts of compound trace elements, 8-10 parts of compound vitamins, 20-25 parts of choline chloride, 70-80 parts of lysine, 20-30 parts of phytase, 60-80 parts of calcium hydrogen phosphate, 5-10 parts of an antioxidant, 100-120 parts of zeolite powder, and 62-95 parts of HPMCP, namely hydroxypropylmethyl cellulose phthalate. The premix for the piglets is a safe and efficient strengthened feed which is rational in formula. The premix is capable of increasing food intake of the piglets, improving anti-stress ability and immunity of the piglets, and effectively raising growth rates of the piglets. The premix is a real safe and efficient feed.

A duloxetine pellet formulation comprises: (i) a core including a desired amount of duloxetine; (ii) an enteric coating comprising hydroxypropylmethylcellulose phthalate (HPMCP) as an enteric polymer; and, optionally, (iii) a separating layer located between the core and the enteric coating, the separating layer including polyvinyl alcohol and a low molecular weight hydroxypropylmethylcellulose (HPMC).

The invention discloses a preparation method of probiotics and dunaliella salina tablets. The method comprises the following steps that 1, probiotics for health-care foods are inoculated into a liquid fermentation medium, anaerobic culture, centrifugal separation and supernatant removing are conducted, and probiotics thalli are collected; 2, the collected probiotics thalli are subjected to resuspension with sterile purified water, and a probiotics suspension is obtained; 3, dunaliella salina powder, xylitol, mannitol, hydroxypropylmethyl cellulose phthalate, polyvinylpyrrolidone and aspartame are fully mixed, smashed and sieved, and dunaliella salina tablet coarse powder is obtained; 4, the dunaliella salina tablet coarse powder is added to the probiotics suspension, the dunaliella salina tablet coarse powder and the probiotics suspension are mixed, granulated and dried, and intermediate granules are obtained; 5, magnesium stearate, silicon dioxide and the intermediate granules are mixed to be uniform, tabletting is conducted, and the probiotics and dunaliella salina tablets are obtained.

The invention relates to an oral nano-vaccine of large yellow croaker and an immune type large yellow croaker feed prepared by the same. The oral nano-vaccine comprises MSN-DLDH nano-particles and enteric coatings coating the surfaces of the MSN-DLDH nano-particles. The MSN-DLDH nano particles are nano particles formed by assembling DLDH protein and a mesoporous silica micro-nano carrying system;and the enteric coatings are hydroxypropyl methylcellulose phthalate. The nano-vaccine disclosed by the invention has the advantages of low cost, simple preparation process, good capability of tolerating a strongly acidic stomach environment of fishes and the like. Besides, the vaccine has no toxicity to kidney cells of the large yellow croaker and is good in biocompatibility; and thus a technicalsupport is provided for research and development of oral nano-vaccines and clinical application in the future.

A solid dispersion, a method for preparing same, and a solid preparation including the solid dispersion. The solid dispersion contains (R)-4-amino-1-(1-(but-2-ynylacyl)pyrrolidin-3-yl)-3-(4-(2,6-difluorophenoxy)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazine-7-one or a pharmaceutically acceptable salt thereof, and a carrier material. The carrier material is selected from hydroxypropyl methylcellulose acetate succinate and hydroxypropyl methylcellulose phthalate.

The invention provides a preparation method of a composite microencapsulated anti-ultraviolet finishing agent. The method includes the following steps that walnut shells are dried, crushed and subjected to ethanol extraction, extraction liquid is concentrated, refrigerated, filtered and heated in sequence, and then the extraction liquid is subjected to standing and is filtered; water is added in the extraction liquid, stirring is performed, activated carbon is added, stirring is performed, heat preservation is conducted, ethanol is added, and then stirring, filtering, heat preservation, standing, filtering and washing are conducted sequentially to obtain walnut shell extract; egg white is mixed with water, polyethylene glycol is added, stirring is conducted, the mixture is subjected to standing for layering, supernate is removed to obtain a precipitate, magnesium chloride is added in the precipitate, stirring is performed, and then stirring centrifugation, washing centrifugation and freeze-drying are conducted sequentially to obtain crude mucin; hydroxypropyl methyl cellulose phthalate, a silane coupling agent, ethyl orthosilicate and an ethanol aqueous solution are taken and stirred, and then the walnut shell extract and the crude mucin are added and stirred; sodium stearyl lactate and sodium lignosulphonate are added and stirred; homogenization, spray drying and cooling are performed sequentially to obtain the finishing agent. A fabric treated with the finishing agent prepared by the method has a good anti-ultraviolet effect and certain antimicrobial property.

The invention relates to microcapsules and a preparation method thereof, particularly to tea polyphenol liposoluble microcapsules and a preparation method thereof, wherein a core material of the tea polyphenol liposoluble microcapsules comprises tea polyphenol and reduced glutathione, a mass ratio of the tea polyphenol to the reduced glutathione is 95-99:1-5, a wall material of the tea polyphenol liposoluble microcapsules is one or a plurality of materials selected from arabic gum, dextrin, corn syrup, ethyl cellulose, methylcellulose, and hydroxypropyl methylcellulose phthalate, and a mass weight ratio of the core material to the wall material is 1:1-4. The tea polyphenol liposoluble microcapsule preparation method comprises the following steps: respectively preparing a core material emulsion liquid and a wall material solution, adding the core material emulsion liquid to the wall material solution, carrying out high speed stirring, homogenizing, and carrying out spray drying to obtain the tea polyphenol liposoluble microcapsules. The tea polyphenol liposoluble microcapsules have characteristics of fine average particle size and slow tea polyphenol release, such that anti-oxidation and absorption utilization efficiency of the tea polyphenol are substantially improved.