51 results about "Cefoperazon" patented technology

The invention discloses a suspension powder injection with a cefoperazone sodium and tazobactam sodium pharmaceutical composition as an active ingredient, and comprises the following components: 4 parts of the cefoperazone sodium, 1 part of the tazobactam sodium, 5-30 parts of an emulsifier, 1-15 parts of an auxiliary emulsifier and 1-40 parts of a freeze-drying support agent. The invention further discloses an application thereof in preparing medicines for treating cystitis.

The invention discloses a stable compound preparation of cefoperazone drug, which is comprised by cefoperazone acid and latent solvent, which weight ratio is 1:0.62~0.06. The latent solvent is preferred selected from sodium carbonate and sodium bicarbonate. Related substances of the compound preparation in the invention and labelled content do not change much in influencing factor and accelerated test in 40 DEG C., which accord with the standard of pharmacopoeia, and the product quality is more stable than cefoperazone sodium during period of validity.

The invention discloses cefoperazone sodium and tazobactam sodium medicinal composition microsphere injection, which is characterized by comprising 4 to 8 weight parts of cefoperazone sodium, 1 to 2 weight parts of tazobactam sodium, 2.5 to 5 weight parts of PLA, 1.25 to 2.5 weight parts of Span60, 1 to 2 weight parts of glycerol monostearate and 1 to 2 weight parts of glucose. Compared with the prior art, the cefoperazone sodium and tazobactam sodium medicinal composition microsphere injection of the invention has the advantages of high stability, high entrapment rate, high-repeatability preparation process suitable for industrial production, uniform particle distribution, little solvent residue, high injectability and good sustained-release property.

The invention discloses a processing technology for cefoperazone sodium tazobactam sodium for injection. The processing technology includes: firstly drying cefoperazone sodium raw material and tazobactam sodium raw material, then conducting powder mixing, finally subpackaging the well mixed cefoperazone sodium and tazobactam sodium antibiotic with well prepared antibiotic bottles, carrying out cover pressing treatment, and then performing light inspection packaging. The processing process is simple and is low in cost, can effectively save time and economic cost, and can reduce the labor intensity of workers.

The invention discloses cefoperazone sodium and sulbactam sodium powder for injection. The cefoperazone sodium and sulbactam sodium powder for injection comprises the following components in parts bymass: 10-26 parts of cefoperazone sodium, 5-12 parts of sulbactam sodium, 0.5-1.2 parts of glutathione, 0.1-0.6 part of sodium phosphate monobasic, 0.1-1.5 parts of disodium hydrogen phosphate and 0.3-0.8 part of sodium chloride, and a pH value of the powder for injection is 5.0-6.5. The cefoperazone sodium and sulbactam sodium powder for injection has excellent stability and an excellent anti-bacterial effect, and the safety is high.

The invention discloses a preparation method of cefoperazone sodium, which comprises the steps of S1, adding acetone into a reaction tank, stirring to control the temperature, and adding cefoperazoneacid to obtain a cefoperazone acid solution; S2, adding purified water and sodium bicarbonate into a dissolving tank, stirring and controlling the temperature to obtain alkali liquor; S3, feeding thealkali liquor in the step S2 into a cefoperazone acid solution, controlling the temperature, and pressing into a crystallizing tank through a degerming and filtering line; S4, respectively introducingsterile nitrogen and acetone into the crystallizing tank through a gas-liquid two-phase nozzle; S5, adding seed crystal, stirring and growing crystal; S6, continuously adding nitrogen and acetone through the gas-liquid two-phase nozzle; and S7, after feeding is completed, conducting cooling, crystal growing, filtering, vacuum drying and discharging. The cefoperazone sodium powder prepared throughthe method is uniform in particle, small in specific volume and low in acetone solvent residue.

The invention belongs to the technical field of medicines, and relates to application of beta-lactam compounds, in particular to application of beta-lactam compounds in production of histone deacetylase inhibitors and application of the beta-lactam compounds in production of anti-tumor-metastasis medicines. According to application of the beta-lactam compounds in production of the histone deacetylase inhibitors and application of the beta-lactam compounds in production of the anti-tumor-metastasis medicines, it is found by research through a substrate-enzyme binding test, immunoblotting, cellenzyme activity detection, a scratch test and a Transwell test that cefoperazone has a significant inhibiting effect on malignant tumor metastasis by inhibiting the activity of HDAC6. Therefore, the beta-lactam compounds represented by the cefoperazone can be used for production of the anti-tumor-metastasis medicines, and have excellent application prospects in prevention and inhibition of postoperative metastasis of malignant tumors.

The invention belongs to the technical field of biological medicine, and particularly relates to application of adenosine or adenosine monophosphate in preparation of anti-infective drugs. The invention relates to a preparation method of the medicine. Adenosine or adenosine monophosphate can significantly improve the effect of clinical escherichia coli, aeromonas hydrophila, vibrio including vibrio alginolyticus and vibrio parahaemolyticus, streptococcus pyogenes, pseudomonas aeruginosa, bacillus faecium, streptococcus iniae, acinetobacter baumannii, klebsiella pneumoniae and other bacteria on the effects of cefoperazone sulbactam, ceftazidime, ceftriaxone sodium, ceftazidime, ceftriaxone sodium, ceftazidime, ceftriaxone sodium, ceftazidime sodium and the like. The sensitivity of antibiotics such as cefoperazone, meropenem, imipenem, ciprofloxacin, ampenem, moxifloxacin, levofloxacin, gentamicin, amikacin, kanamycin and the like is improved, the compound can be used together with the antibiotics to serve as an anti-infection drug, bacteria are killed under the condition of low-concentration antibiotics, and a good anti-infection effect is achieved; meanwhile, the generation of bacterial drug resistance is reduced.

The invention relates to cefoperazone sodium for injection and a preparation method thereof, and belongs to the technical field of medicine. The cefoperazone sodium for injection is prepared by adding 500g to 2000g of cefoperazone sodium, sodium citrate, povidone K30, adding 2000ml of water for injection and then freeze-drying. The cefoperazone sodium for injection obtained by the invention has good quality and high stability, is superior to the prior art, and greatly improves the effectiveness and safety of the cefoperazone sodium for injection in clinical use.

The invention discloses a medicine formula for treating prostatitis and benign prostatic hyperplasia and a preparation process thereof. The medicine formula comprises the following components by weight: 1000 to 8000 mg of cefoperazone sodium sulbactam sodium, 2 to 40 mg of edetate disodium, 1 to 20 mg of dexamethasone, 20 to 200 mg of levobupivacaine, and 40 to 400 mg of procaine. The compatible formula is directly administered through prostate microneedle injection, so that the effects of resisting bacteria, diminishing inflammation and relieving prostatic fibrosis in the prostate body are achieved to the maximum extent, and the formula is suitable for treating various chronic prostatitis and benign prostatic hyperplasia. A large number of clinical cases prove that the formula has the advantages of remarkable curative effect, no pain in treatment, safety, no side effect and the like.

The invention discloses a method for determining cefoperazone sodium and sulbactam sodium related substances for injection. The method comprises the following steps: preparing a solution by using solution preparation equipment, adding cefoperazone sodium and sulbactam sodium powder into a mixing tank through a feeding hopper, introducing water into the mixing tank, closing the feeding hopper, andstarting a driving mechanism and a heating mechanism. According to the method for determining the cefoperazone sodium and sulbactam sodium related substances for injection, the cefoperazone sodium andsulbactam sodium powder can be rapidly dissolved through forward and reverse rotation of a stirring frame I and a stirring frame II in the mixing tank, the temperature of the solution is increased bythe heating mechanism, and the dissolving efficiency of medicine powder is further improved; the dissolving effect of the cefoperazone sodium and sulbactam sodium powder is effectively improved, 14 impurities in the cefoperazone sodium and sulbactam sodium for injection can be effectively separated and quantitatively determined by adopting a newly established RPHPLC method, the system applicability of chromatography is high, the product quality can be more effectively controlled, and safe popularization and application are facilitated.

The invention discloses a purification method of cefoperazone sodium, which comprises the steps of S1, adding a cefoperazone sodium and sulbactam sodium product into purified water, stirring until thesolution is clear, controlling the temperature, adding acetone into the reaction tank, and starting stirring until the cefoperazone sodium and sulbactam sodium are completely dissolved to obtain a dissolved solution; S2, adding activated carbon into the dissolved solution for decoloration, and filtering to obtain a destaining solution for later use; S3, adding acetone, isopropanol and ethanol into a crystallizer to obtain a mixed solution, and controlling the temperature of the crystallizer; S4, adding the destaining solution obtained in the step S2 into the crystallizer in a rapid stirring state, then dropwise adding a sodium bicarbonate solution to adjust the pH value of the feed liquid, and growing crystals; S5, after crystal growing is finished, cooling for crystal growing, filtering,and washing with an acetone-water mixed solution; and S6, conducting vacuum drying and discharging. The prepared cefoperazone sodium has the advantages of being stable in quality, low in impurity content and high in product content.