112 results about "Cefoperazone Sodium" patented technology

The invention aims to provide a method for crystallizing cefoperazone sodium, which comprises the following steps of: dissolving cefobid in a solvent, and adding a salt forming agent to adjust the pH to between 6.2 and 6.8 until the solid is completely dissolved; and filtering, adding the filtrate into the solvent under the ultrasonic condition to separate out crystals, filtering, washing and leaching the crystals, and performing vacuum drying to obtain the cefoperazone sodium. Aiming at the problems in the industrial crystallization of the cefoperazone sodium, the ultrasonic radiation has strong orienting effect, supplements and enhances the wave action required by the formation of critical crystal nucleus, can accelerate graining process and promote the quick generation of the crystal nucleus, and achieves the effect of quickly graining without seeding by seed crystals; meanwhile, the ultrasonic in the liquid medium can make mass points in the medium obtain high acceleration, has the effect of cavitation, and can prevent the accumulation during crystal growth to make the size distribution of the crystals uniform.

A preparation process for cefoperazone sodium and tazobactam sodium for injection is disclosed, which comprises the following steps of: (1) mixing for cefoperazone sodium powder and tazobactam sodium powder; (2) cleaning for bottle: straightening a bottle, cleaning the bottle by an ultrasonic wave, and sterilizing by dry heat in a tunnel drying oven; (3) cleaning for stopper: cleaning a rubber stopper, sterilizing and drying; (4) sterile subpackaging; (5) treatment for aluminium cap; (6) lamp inspection for capping; (7) labelling; and (8) boxing.

The invention relates to a cefoperazone sodium-sulbactam sodium eutectic crystal and a pharmaceutical composition containing the eutectic crystal, and preparation methods thereof. The cefoperazone sodium-sulbactam sodium eutectic crystal has the advantages of concentrated distribution of crystal form grain size, good product fluidity, gloss surface, high degree of crystallinity and good stability; the preparation method of the crystal form is simple in process, easy to operate, and suitable for popularization and application in a wide range. In the compound cefoperazone sodium-sulbactam sodium preparation, through introduction of the cefoperazone sodium-sulbactam sodium eutectic crystal and a phosphate buffer to adjust the pH value, the problems that a mixed powder in the preparation is poor in uniformity, liquidity and raw material stability are solved, generation of carbon dioxide gas due to addition of a stabilizer carbonate is avoided, an obtained powder injection is diluted through conventional transfusion, then dissolved rapidly and does not produce crystallization and degradation products, the solution clarity is in accordance with provisions, the solution pH value has no obvious change, and the contents of cefoperazone sodium and sulbactam sodium are stable.

The invention relates to the field of medicinal chemistry, in particular to an ambroxol derivative and a preparation method thereof and application of the ambroxol derivative in drugs for eliminating phlegm. The ambroxol derivative is a compound shown in a structure in the description or a stereoisomer, and please refer to figure 1 for the specific structure, wherein R1 represents H or alkali metal ions or organic amine, and R2 represents H or alkali metal ions or organic amine. The ambroxol derivative has good solubility, the solution pH is larger than 7, no sediment is separated out, the ambroxol derivative can be used concomitantly with cefoperazone sodium, a wider pH solubility range is achieved, the oral bioavailability is high, and the drug efficacy is greatly strengthened.

The invention belongs to the technical field of medicines, and particularly relates to cefoperazone sodium and tazobactam sodium pharmaceutical composition for injection and a preparation method of the cefoperazone sodium and tazobactam sodium pharmaceutical composition. The pharmaceutical composition is a freeze-dried powder preparation. The mass ratio of cefoperazone sodium to tazobactam sodium in the pharmaceutical composition is 4:1. The preparation method comprises the steps as follows: firstly, tazobactam is refined; then, tazobactam sodium is prepared from refined tazobactam and sodium bicarbonate; finally, cefoperazone sodium and prepared tazobactam sodium are uniformly mixed for preparation of freeze-dried powder. Compared with like products sold in the market, the pharmaceutical composition has the advantages of good solubility, light color, few related substances, small polymer content and low adverse reaction rate; besides, effective constituents in the pharmaceutical composition are stable, and when the pharmaceutical composition is preserved for a long term, few effective constituents are degraded, the content of impurities is low, the quality performance of products is relatively good, and the medication safety of patients is guaranteed accordingly.