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Injection powder and injection preparation of cefoperazone sodium-tazobactam combination

A kind of injection powder, tazobactam sodium technology, applied in the field of cefoperazone sodium and tazobactam sodium composition injection powder

Active Publication Date: 2012-07-11
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when cefoperazone sodium and tazobactam sodium injection are used in clinical injection, they are often accompanied by pain.

Method used

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  • Injection powder and injection preparation of cefoperazone sodium-tazobactam combination
  • Injection powder and injection preparation of cefoperazone sodium-tazobactam combination
  • Injection powder and injection preparation of cefoperazone sodium-tazobactam combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Cefoperazone Sodium and Tazobactam Sodium Composition Powder for Injection provided by the present invention

[0024] Accurately weigh 800g of cefoperazone sodium, 200g of tazobactam sodium, and 10g of lidocaine hydrochloride, pass through a 100-mesh sieve, mix, fine filter, fill, seal, and then prefreeze at -55°C for 1 hour The sublimation temperature is -35°C, the sublimation time is 5h; the drying temperature is 30°C, and the drying time is 11h, and freeze-drying is carried out to obtain the cefoperazone sodium and tazobactam sodium composition powder for injection.

Embodiment 2

[0025] Example 2 Cefoperazone Sodium and Tazobactam Sodium Composition Powder for Injection provided by the present invention

[0026] Accurately weigh 1600g of cefoperazone sodium, 400g of tazobactam sodium, and 100g of lidocaine hydrochloride, pass through an 80-mesh sieve, after mixing, fine filter, fill, seal, and then prefreeze at -30°C for 8 hours The sublimation temperature is -10°C, the sublimation time is 20h; the drying temperature is 15°C, and the drying time is 15h, and freeze-drying is carried out to obtain the cefoperazone sodium and tazobactam sodium composition powder for injection.

Embodiment 3

[0027] Example 3 Cefoperazone Sodium and Tazobactam Sodium Composition Powder for Injection provided by the present invention

[0028] Accurately weigh 800g of cefoperazone sodium, 200g of tazobactam sodium, and 50g of lidocaine hydrochloride, pass through a 90-mesh sieve, mix, fine filter, fill, seal, and then prefreeze at -45°C for 3 hours The sublimation temperature is -27°C, the sublimation time is 10h; the drying temperature is 42°C, and the drying time is 7h, and freeze-drying is carried out to obtain the cefoperazone sodium and tazobactam sodium composition powder for injection.

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Abstract

The invention relates to the technical field of medicine, in particular to an injection powder and injection preparation of a cefoperazone sodium-tazobactam combination. The injection powder and injection preparation comprises cefoperazone sodium, tazobactam combination and lignocaine hydrochloride, wherein the mass ratio of the cefoperazone sodium to the tazobactam combination to the lignocaine hydrochloride is 4:1:(0.01-0.05). Compared with a positive medicament control group, the injection powder and injection preparation of the cefoperazone sodium-tazobactam combination provided by the invention has the advantages of capability of relieving injection pain and remarkable improvement on the curative effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cefoperazone sodium and tazobactam sodium composition powder for injection. Background technique [0002] Cefoperazone, chemical name: (6R,7R)-3-[[(1-methyl-1H-tetrazol-5-yl)sulfur]methyl]-7-[(R)-2-(4 -Ethyl-2,3-dioxo-1-piperazinecarbonylamino)-2-p-hydroxyphenyl-acetylamino]-8-oxo-5-thia-1-azabicyclo[4,2 , 0] Oct-2-ene-2-formic acid sodium salt, the molecular formula is: C 25 h 26 N 9 NaO 8 S 2 , the molecular weight is: 667.66, and the structural formula is: [0003] [0004] Cefoperazone is a third-generation cephalosporin antibiotic with a broad antibacterial spectrum and strong effect. It has a strong antibacterial effect on Pseudomonas aeruginosa. It achieves bactericidal effect by inhibiting the biosynthesis of sensitive bacterial cell walls. The characteristics of its action are: strong against anaerobic bacteria and Gram-negative bacteria, (including Pseudomo...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/431A61K31/167A61K9/19A61P31/04A61P23/02
Inventor 刘明霞路华美王春艳
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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