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Cefoperazone sodium and sulbactam sodium composition

A technology of cefoperazone sodium and sulbactam sodium, applied in the directions of heterocyclic compound active ingredients, drug delivery, organic active ingredients, etc., can solve the problems of decreased clearance and accumulation of sulbactam, so as to reduce the possibility of adverse reactions, The effect of reducing production cost and wide clinical application range

Inactive Publication Date: 2008-03-19
CHENGDU BOAOTONG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In the compound preparation of cefoperazone and sulbactam, because cefoperazone is mainly cleared through the liver, but only through the kidneys, clinical studies have confirmed that in patients with renal impairment, the clearance rate of sulbactam is significantly reduced, and it is easy to cause accumulation in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Under aseptic conditions, accurately take cefoperazone sodium (Suzhou Dongrui Pharmaceutical Co., Ltd., sterile bulk drug 040130004) and sulbactam sodium (Suzhou Dongrui Pharmaceutical Co., Ltd., sterile bulk drug 040110007) in a ratio of 3:1, The above two medicines were placed in a powder mixer and mixed for 15 minutes to make them fully mixed uniformly to obtain sample 1 of the cefoperazone sodium / sulbactam sodium (3:1) composition of the present invention.

[0018] The obtained sample 1 can be subpackaged and packaged according to common methods in the field of pharmacy. For example, vials can be used as packaging materials, and rubber stoppers, rolled aluminum caps, etc. can be used to complete the packaging. The vial is an inert material and has no chemical reaction with the packaged raw materials. When using or testing, dissolve and dilute the dry powder drug with sterile water to the final concentration of the drug required for the test.

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PUM

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Abstract

The invention provides a combination of cefoperazone sodium and sulbactam sodium. The combination consists of the cefoperazone sodium and the sulbactam sodium, and the weight ratio of which is 3 to 1. The combination of cefoperazone sodium and sulbactam sodium of the invention has the comparative curative effect at the aspect of antibacterial effect with a compound preparation of 1 to 1 or 2 to 1 of the cefoperazone sodium / the sulbactam sodium in markets. The invention reduces the corresponding content of the sulbactam sodium in the combination, so the invention has wider clinical application range and can reduce the production cost of the drug. Compared with the prior compound preparation of the cefoperazone sodium / the sulbactam sodium, the invention is characterized by being fit for the anti-infection remedy of the patient with the renal dysfunction and the remedy of the seriously infected patient.

Description

Technical field [0001] The present invention relates to an antibacterial pharmaceutical composition, in particular to an anti-β-lactamase antibiotic compound preparation. Background technique [0002] Humans have invented a large number of antibacterial drugs and put them into clinical application. However, due to the long-term and extensive use of antibiotics, bacterial resistance has also developed rapidly, and drug-resistant strains continue to emerge, especially resistance caused by β-lactamase. The most serious drug properties have become a major problem in clinical treatment. [0003] Cefoperazone is a third-generation semi-synthetic cephalosporin antibiotic that mainly inhibits bacterial cell wall synthesis. Cefoperazone sodium has the characteristics of broad antibacterial spectrum, strong antibacterial effect and stability against lactamase produced by bacteria. However, due to unreasonable clinical application, bacteria develop drug resistance, and drug-resistant ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K31/43A61K9/00A61P31/04
Inventor 金勇
Owner CHENGDU BOAOTONG TECH
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