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Preparation method for injection cefoperazone sodium tazobactam sodium composition

A technology of cefoperazone sodium and tazobactam sodium, which is applied in the direction of active ingredients of heterocyclic compounds, medical preparations containing active ingredients, and pharmaceutical formulations, and can solve the problem of losing antibacterial activity

Inactive Publication Date: 2013-05-29
LIAONING HAISCO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cefoperazone sodium is a third-generation cephalosporin antibiotic, which achieves bactericidal effect by inhibiting the biosynthesis of sensitive bacterial cell walls, but is easily hydrolyzed by β-lactamase and loses its antibacterial activity

Method used

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  • Preparation method for injection cefoperazone sodium tazobactam sodium composition
  • Preparation method for injection cefoperazone sodium tazobactam sodium composition
  • Preparation method for injection cefoperazone sodium tazobactam sodium composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Specification: 1.0g (Example 1a)

[0015] prescription:

[0016] Cefoperazone sodium 800g (calculated as cefoperazone)

[0017] Tazobactam sodium 200g (calculated as tazobactam)

[0018]

[0019] Makes 1000 bottles

[0020] Specification: 2.0g (Example 1b)

[0021] prescription:

[0022] Cefoperazone sodium 1600g (calculated as cefoperazone)

[0023] Tazobactam sodium 400g (calculated as tazobactam)

[0024]

[0025] Makes 1000 bottles

[0026] Preparation:

[0027] 1. Grind cefoperazone sodium and tazobactam sodium to 80 meshes respectively, weigh the two raw materials according to the prescription amount, and set aside;

[0028] 2. Add the above two raw materials into the mixer and mix them evenly, and detect the content of the two components;

[0029] 3. Dispensing, control the filling volume between 97% and 103% of the marked filling volume, divide 1.0g into 10ml low borosilicate glass control injection bottle (Example 1a), and divide 2.0g into 25ml l...

Embodiment 2

[0036] Specification: 1.0g

[0037] prescription:

[0038] Cefoperazone sodium 800g (calculated as cefoperazone)

[0039] Tazobactam sodium 200g (calculated as tazobactam)

[0040]

[0041] Makes 1000 bottles

[0042] Preparation:

[0043] 1. Grind cefoperazone sodium and tazobactam sodium to 60 meshes respectively, weigh the two raw materials according to the prescription amount, and set aside;

[0044] 2. Add the above two raw materials into the mixer and mix them evenly, and detect the content of the two components;

[0045] 3. Divide into 10ml low-borosilicate glass control injection bottles, control the filling volume between 97% and 103% of the marked filling volume, press the stopper and tie the cap;

[0046] 4. Paste the inner label and pack according to 1 bottle / box;

[0047] 5. After passing the inspection, the finished product will be obtained.

[0048] Note: The above steps 1~3 require the ambient humidity to be controlled within 45%.

Embodiment 3

[0050] Specification: 1.0g

[0051] prescription:

[0052] Cefoperazone sodium 800g (calculated as cefoperazone)

[0053] Tazobactam sodium 200g (calculated as tazobactam)

[0054]

[0055] Makes 1000 bottles

[0056] Preparation:

[0057] 1. Grind cefoperazone sodium and tazobactam sodium to 100 mesh respectively, weigh the two raw materials according to the prescription amount, and set aside;

[0058] 2. Add the above two raw materials into the mixer and mix them evenly, and detect the content of the two components;

[0059] 3. Divide into 10ml low-borosilicate glass control injection bottles, control the filling volume between 97% and 103% of the marked filling volume, press the stopper and tie the cap;

[0060] 4. Paste the inner label and pack according to 1 bottle / box;

[0061] 5. After passing the inspection, the finished product will be obtained.

[0062] Note: The above steps 1~3 require the ambient humidity to be controlled within 45%.

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Abstract

The invention provides a preparation method for injection cefoperazone sodium tazobactam sodium composition. The preparation method comprises the following steps of: crushing the cefoperazone sodium and the tazobactam sodium; and mixing the cefoperazone sodium and the tazobactam sodium in a weight ratio of 4:1; and separately packaging, pressing and capping the mixture. The preparation method is characterized in that the fineness of pulverization of the cefoperazone sodium and the tazobactam sodium is 50-120 meshes.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method of a composition of cefoperazone sodium and tazobactam sodium for injection and the composition prepared by the method. Background technique [0002] Cefoperazone Sodium and Tazobactam Sodium for Injection (Cefoperazone Sodium and Tazobactam Sodium for Injection) is a compound preparation composed of cefoperazone sodium and tazobactam sodium. g; 2.0g specification contains cefoperazone 1.6g and tazobactam 0.4g. It is mainly used for the treatment of moderate and severe infections caused by β-lactamase-producing bacteria resistant to cefoperazone sodium single drug and sensitive to this product; lower respiratory tract infection; genitourinary system infection; abdominal cavity, pelvic infection and other infections. [0003] Cefoperazone Sodium and Tazobactam Sodium for Injection is a compound preparation composed of cefoperaz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K31/431A61K9/14A61P31/04
Inventor 郑伟
Owner LIAONING HAISCO PHARMACEUTICAL CO LTD
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