50 results about "Genitourinary system" patented technology

Natural and / or synthetic materials to form a strong barrier between the skeletal system and the great vessels. In the preferred embodiments, a natural or synthetic material is used to prevent scar tissue from forming around the vessels and / or to act as barrier placed between the vessels and the skeletal system, including the spine. Devices according to the invention may also be used over the dura and nerves following laminectomy procedures, between the sternum and the pericardium or heart following cardiac procedures, in intra-abdominal procedures such as intestinal or vascular surgery, over the brain in intra-cranial surgery, over the ovaries or other organs or tissues in the female genitourinary system, over the prostate or other organ or tissues in the male genitourinary system, or in other surgeries on humans or animals.

Disclosed are compounds that modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include compounds of the Formulae 1, 2, 3, 4, and 5.

The present invention generally relates to the field of prostheses for surgical applications, to methods of their manufacturing and to methods of treating a patient by implanting them into a patient. More particularly, the present invention relates to prostheses having a multi-layered sheet structure and their use in hernia repair, the repair of anatomical defects of the abdominal wall, diaphragm, and chest wall, correction of defects in the genitourinary system, and repair of traumatically damaged organs such as the spleen, liver or kidney.

The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments.

The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

Implantable drug delivery devices are provided lo have a deployment shape for implantation in the body and a retention shape for retention in the body. The device may have one or more elongated drug reservoirs containing a drug, mid the drug reservoir may be formed from a deformable material. In one case, a first filament is attached to the first end of the drug reservoir and second filament is attached to the second end of the drug reservoir, wherein a fastener is positioned about the first and second filaments to permit shortening and prevent lengthening of the filaments with reference to the ends of the daig reservoir, as a means for transforming the device from the implantation shape to the retention shape.

The invention discloses compounds having virus resistance and a composition thereof. The composition comprises one or more of the 13 compounds comprising 6'-O-caffeoyl deacetyl asperulosidic acid methyl ester. The compounds having virus resistance and the composition thereof can be extracted from plants and can also be prepared by synthesis. The composition comprising the compounds having virus resistance can prevent and treat viral infection-caused diseases such as influenza, myocarditis, conjunctivitis, viral pneumonia, encephalitis, leukemia, hepatitis B, hepatitis C, AIDS, genitourinary system infection, EB virus infection, human papillomavirus infection and cytomegalovirus infection. The composition can be prepared into an oral preparation, an injection, a spray, a subcutaneous injection and an anus suppository.

The invention relates to a corning pill which comprises plantain seed, fringed pink, polygonum aviculare, soapstone, earthworm, seaweed, laminaria, pangolin, red flower, peach kernel, honeysuckle, cordate houttuynia, gardenia, scutellaria baicalensis, agilawood, fructus amomi, cowherb seed, elecampane, mangnolia officinalis and fructus aurantii. The corning pill has the major functions of treatingmale genitourinary system diseases including male infertility, prostatitis, orchitis, seminal vesiculitis, male and female urethritis, cystitis and the like.

The invention discloses an application of a compound as a JAK-STAT3 signal passage inhibitor, and particularly relates to an application of a compound with a formula I or pharmaceutically acceptable salt of the compound in the process of preparing an anti-tumor medicament. The application provides a novel treating candidate medicament for a tumor patient, thereby probably further improving the treatment effect on the patient and improving the prognosis of the patient. The compound with the formula I or the pharmaceutically acceptable salt of the compound has the effect on various tumor cells, which indicates that the compound can be used for treating various cancers including cerebral tumor, genitourinary system tumor, lymphatic system tumor, stomach cancer, laryngeal cancer, nasopharyngeal cancer, skin cancer, bone cancer, blood cancer, leukemia, breast cancer and histiocytic lymphoma, non-small cell lung cancer, small-cell lung cancer, lung adenocarcinoma, lung squamous cell cancer, pancreatic cancer, prostatic cancer, liver cancer, epithelial cell cancer and the like. The definition of genes in the formula refers to description for details.

An ultrasound scanning system and methods of using the same. In one preferred form, an ultrasound scanning system comprises an acoustic imaging catheter comprising an ultrasonic transducer, a motion control system and an imaging computer system for imaging a patient's genitourinary system. In another preferred form, an ultrasound scanning system is used for imaging a patient's prostate gland.

The invention relates to a cefathiamidine hydrate and a preparation method and application thereof. The crystalline hydrate has high storage stability, is suitable for preparing bacteria sensitive to Gram-positive or negative bacteria, and is applied to the preparation of medicaments for treating or preventing infection of respiratory systems, liver and gall bladder systems, five sense organs, urogenital systems, bones, joints and skin soft tissues as well as diseases such as endocarditis, septicemia, brain fever and the like of human beings or animals caused by bacteria which are sensitive to Gram-positive or negative bacteria.

The invention relates to a medicine, in particular to a medicine for treating female genitourinary system inflammation. The medicine is prepared by the following raw medicine materials in parts by weight: 25-35 parts of felwort, 8-12 parts of rhizoma alismatis, 8-12 parts of cortex dictamni, 8-12 parts of coptis, 25-32 parts of lightyellow sophora root, 7-13 parts of akebiaquinata, 8-12 parts of Cyrtomium fortunei, 7-14 parts of fineleaf schizonepeta herb, 12-20 parts of Chinese thorowax root, 12-18 parts of plantain seed, 12-18 parts of golden cypress, 7-12 parts of stiff silkworm, 9-12 parts of pangolin scale, 12-18 parts of Salvia miltiorrhiza Bunge, 8-15 parts of licorice root, 12-20 parts of Chinese angelica, 12-20 parts of divaricate saposhnikovia root and 8-15 parts of fructus cnidii. The invention has the advantages that the effects of the medicine on female genitourinary system inflammation, including acute and chronic vaginitis, pruritus vulvae, leucorrhea increase, peculiar smell, cervicitis, cervical erosion, pelvic inflammation, ovarian cyst and the like according to a great amount of clinical experiments are obvious, and certain efficacies on mammary gland proliferation, hysteroptosis, uterine myoma, endometriosis and the rehabilitation therapy after delivery operation are also obtained.

The present invention relates to a crystal form of lomefloxacin aspartate and a preparation method thereof. The present invention also relates to a pharmaceutical composition containing the above-mentioned crystal form of lomefloxacin aspartate and the crystal form is used to manufacture a treatment for Gram Human or animal respiratory tract infection, genitourinary system infection, gastrointestinal bacterial infection, abdominal cavity, biliary tract, typhoid and other infections, bone and joint infection, skin and soft tissue infection, sepsis and other systemic infection caused by positive or negative bacterial sensitive bacteria, Other infections, such as sinusitis, otitis media, blepharitis and other drugs.

The invention discloses a special fabric for male shorts. The fabric comprises a bacterial inhibition protection layer and an elastic moisture absorption layer, wherein the bacterial inhibition protection layer is arranged on the surface of the elastic moisture absorption layer and is bacterial inhibition cloth prepared from bamboo fibers, chitin fibers and polyester low elastic filaments; the elastic moisture absorption layer is moisture absorption cloth prepared from flax fibers, polyurethane fibers, cotton fibers and polyester high elastic filaments; the bacterial inhibition protection layer is sewed with the elastic moisture absorption layer by a plurality of parallel elastic silk threads. According to the fabric, the dual-layer structure is adopted, the bacterial inhibition protection layer has the effects of bacterial inhibition and moisture absorption, and the elastic moisture absorption layer has the effects of moisture absorption, softness, rich elasticity and bacterial inhibition, so that the produced male shorts are comfortable to wear, high in bacterial inhibition property and capable of effectively protecting the health of a genitourinary system.

The invention relates to a method for preparing a genitourinary system tumor cell ferroptosis model based on ferric ammonium citrate and application in preparation of antitumor drugs, and belongs to the technical field of antitumor drugs. The invention provides the method for preparing the genitourinary system tumor cell ferroptosis model based on ferric ammonium citrate. The method comprises thefollowing steps: when the density of cultured tumor cells reaches 65-75%, adding ferric ammonium citrate, and continuing to culture for 20-30 hours to obtain the ferroptosis model. The way of treatinggenitourinary system tumor cells by using the ferric ammonium citrate is a very simple, convenient and efficient method for preparing the a ferroptosis tumor cell model, and the anti-tumor activity of the ferric ammonium citrate provides a theoretical basis for subsequent research and development and clinical treatment.

Compositions include synergistic combinations of xyloglucans and vegetable or animal proteins that are useful in the treatment of intestinal disorders or of disorders originating from the intestinal system and transferred to other systems, such as the genitourinary system. The compositions include xyloglucans or an extract containing xyloglucans, and one or more animal or vegetable proteins. Methods for the treatment or prevention of intestinal disorders are provided, including prevention of diarrhoea.

The invention provides application of a known chemical compound to preparing medicines for treating tumor, and discloses an anticancer agent. The anticancer agent has the advantages that effects of suppressing carcinoma in situ or metastatic carcinoma of diversified systems such as nervous systems, digestive systems, genitourinary systems, skin, bone and joint systems, respiratory systems and blood and gland systems can be realized by the anticancer agent; effects of suppressing benign and malignant tumor can be realized by the anticancer agent; the anticancer agent is safe, is free of toxicity and can be hopefully newly widely applied to the fields of healthcare foods and medicines.

The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to a kidney-tonifying traditional Chinese medicine composition, and also relates to a preparation method of the composition. The composition comprises the following components in parts by weight: 15-25 parts of Chinese yam, 10-20 parts of salvia miltiorrhizak, 5-15 parts of Chinese angelica, 8-15 parts of jujube peel, 10-20 parts of safflower, 8-18 parts of ligusticum wallichii, 1-6 parts of asarum herb, 8-18 parts of cortex mori, 6-15 parts of radix rehmanniae, 4-12 parts of radix rehmanniae preparata, 6-18 parts of scutellaria baicalensis, 8-20 parts of ophiopogon japonicas, 8-18 parts of cynanchum paniculatum, 15-25 parts of achyranthes bidentata, 8-18 parts of rhizoma cibotii, 6-15 parts of notopterygium incisum, 5-12 parts of placenta hominis, 5-18 parts of matrimony vine, 5-15 parts of semen cuscutae, 5-15 parts of ligustrum lucidum and 5-15 parts of raw licorice. The beneficial effects comprise that the kidney-tonifying traditional Chinese medicine composition prepared by employing the above formula and the method is capable of regulating qi-blood circulation of kidney and kidney meridian or regulating organ tissues such as related urinary and reproduction systems and the like which are related to kidney in functions, is fast in kidney-tonifying effectiveness, has no toxic and side effects on human body, and is good in treatment effect.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition capable of tonifying the kidneys. The traditional Chinese medicine composition is prepared from Chinese yams, angelica sinensis, chuanqiong rhizome, glossy privet fruits, radix polygoni multiflori, rhizoma cibotii, radix cynanchi paniculati, semen cuscutae, human placenta, fructus foeniculi, ginseng, corn cervi pantotrichum, milkvetch roots, wolfberry fruits, herba leonuri, fructus schisandrae chinensis, poria cocos, rhizoma atractylodis macrocephalae, rhizoma et radix notopterygii, herba asari, penis cervi, capillary wormwood herbs, endothelium corneum gigeriae galli, hippocampi, manyflower solomonseal rhizome, cassia seeds, herba taxilli, kudzuvine roots, jujubes, arillus longan, radix et rhizoma rhei, cortex eucommiae, lilies, Chinese thorowax roots, herba houttuyniae and isatis roots. The traditional Chinese medicine composition is used for regulating Qi and blood circulation of kidneys and kidney channels or organs and tissue such as related urinary and reproductive systems of which the functions are related with the kidneys, the effect of tonifying the kidneys is fast, toxic and side effects on a human body do not exist, and the treatment effect is good. Compared with congeneric drugs, the traditional Chinese medicine composition has the advantages of being rigorous in compatibility, mild in drug property and significant in curative effect, and large-area application and promotion on clinic are convenient.

The invention relates to an egg yolk culture medium for amino acid neutralization, in particular to a prescription of a culture medium used when a gonorrhea patient need the gonococcus culture examination after using a large amount of clinical antibiotics and a preparation method of the culture medium. The gonococcus culture examine is an important method used for diagnosing gonorrhea. The purulent inflammation which is the disease of genitourinary system and caused by gonococcus is one of the pathogens to which clinical doctors attach importance. Especially when the large amount of clinical antibiotics is used, the gonococcus detection is very difficult because a sample contains a large amount of residual antibiotics, and the recovered gonococcus culture is still influenced by the residual antibiotics, therefore the design mistake of not adopting an experiment for removing the residual antibiotics is very serious, and the result obtained by the experiment is not reliable. The invention aims to provides an egg yolk culture medium for amino acid neutralization, which is used for clinically judging the gonococcus used in the sample of a genitourinary tract.

Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

The invention discloses a private protection probiotic composition, and belongs to the field of all related food industries of probiotics. The composition comprises lactobacillus rhamnosus, lactobacillus paracasei and cranberry powder. The private protection probiotic composition can be taken for a long time, effectively reduces the pH value in the vagina, increases the lactobacillus content in the vagina, can achieve safe and lasting colonization in the vagina, can inhibit the activity of various pathogenic bacteria, and can be used as a food supplement or medicine for improving various urogenital system diseases including bacterial vaginitis (BV), yeast vaginitis (YV) and urinary tract infection (UTI) and reducing infection and recurrence risks.

The invention discloses a selenium-rich probiotic solid drink and a preparation method thereof, and belongs to the technical field of microbial food processing. The selenium-rich probiotic solid drinkis prepared from selenium-rich probiotics live bacteria lyophilized powder, microcapsule cranberry extractive, milk-vetch root polysaccharides, Chinese wolfberry polysaccharides, and fructo-oligosaccharide. The preparation method comprises the following steps: (1) cranberry raw material treatment; (2) preparation of the cranberry extractive; (3) microencapsulation and drying pulverization of thecranberry extractive; (4) culturing of selenium-rich probiotics; (5) microencapsulation and drying pulverization of the selenium-rich probiotics; and (6) polysaccharide preparation; and (7) componentcompounding. The selenium-rich probiotic solid drink can regulate intestinal flora, improve an immune system, has a high organic selenium content, can achieve the effect of safe selenium supplement, and has the special functions of protecting a female genitourinary system, maintaining vaginal health and skin health.

The invention discloses application of drug combination of bacteroides fragilis and a PD-1 antibody and / or a PD-L1 antibody in prevention and treatment of tumors of a genitourinary system. A large number of experiments prove that the bacteroides fragilis, especially the bacteroides fragilis ZY-312 with the preservation number of CGMCC No.10685, can be used for effectively preventing and treating the tumors of the genitourinary system by regulating immune factors, improving the state of immune cells and enhancing the anti-tumor immune response of a body.

Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

The present invention is directed to a system for treating uro-genital conditions. One aspect of this invention involves the treatment system comprising one or more polypeptides with a amino acid sequence including KPV (SEQ. ID. NO. 1), MEHFRWG (SEQ. ID. NO. 2) HFRWGKPV (SEQ. ID. NO. 3), SYSMEHFRWGKPV (SEQ. ID. NO. 4), for treatment of uro-genital conditions. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above. Uro-genital conditions can include infections, inflammation, or both. In one preferred embodiment of the invention, the uro-genital condition includes infection and / or inflammation of the vagina, vulva, urinary tract, penis, and / or the rectum. In another preferred embodiment of the invention, the one or more polypeptides are dissolved in a carrier. In another preferred embodiment of the invention, the one or more polypeptides are associated with a tampon for preventing toxic shock syndrome. In another preferred embodiment, the one or more polypeptides are associated with a contraceptive for prevention of sexually transmitted diseases or infections. In another preferred embodiment, the one or more polypeptides are associated with a suppository for insertion into the vagina or rectum.

The invention belongs to the technical field of drug preparation, and particularly relates to a preparation method of a drug intermediate for an urogenital system. 2-amino terephthalic acid and nickelchloride hexahydrate serve as raw materials, a metal organic skeleton structure is formed, then the metal organic skeleton structure is loaded with certain Pd, and finally a load type high-dispersionPd / Ni co-doped double-component catalyst is obtained through reduction at high temperature. The catalyst is adopted to catalyze 2-bromo-5-nitro-3-(trifluoromethyl)pyridine to be subjected to a cyanation reaction to prepare the drug intermediate 2-cyano-5-nitro-3-(trifluoromethyl)pyridine for the urogenital system, the yield is high, and post-treatment is simple, the high-purity target product canbe obtained by adopting extraction and concentration, and column chromatography purification is not needed; and the catalyst can be conveniently removed from the system, and can be recycled.

The invention provides a PLGA multi-target composite nano reagent for targeting tumor neovascularization and a preparation method and application of the PLGA multi-target composite nano reagent, and relates to the technical field of biological medicines. According to the PLGA multi-target composite nano reagent for the targeting tumor neovascularization, a PLGA nano material is combined with a plurality of effective siRNA oligo expressed by PD-L1, CD47, PDGFR, EGFR and CD155 in a targeted silencing mode and is loaded with a plurality of DNA fragments having specific sequence and called Fastener Strand, and therefore the muiti-siRNAs (at) PLGA multi-target composite nano reagent is obtained. According to the PLGA multi-target composite nano reagent for the targeting tumor neovascularization, the multi-siRNAs (at) PLGA transfected genitourinary system tumor cell line is utilized to obviously inhibit the proliferation and migration capabilities of genitourinary system tumor cells, obviously enhance the killing activity of CD56 + NK cells and CD8 + T cells on the tumor cells and the release capability of inflammatory factors, and therefore the muiti-siRNAs (at) PLGA multi-target composite nano reagent can be used as a chemotherapeutic preparation for inhibiting the genitourinary system tumors.