123 results about "Bacterial vaginitis" patented technology

The invention relates to chitosan gel for women. The chitosan gel for women is obtained by mixing chitosan with specific molecular weight and degree of deacetylation, glycerol, acidifier and purified water in a gelatinization manner and then sterilizing. The chitosan gel for women, provided by the invention, has good adhesive power, uniform colour and lustre and stability, and has the advantages of good curative effect, safety, natural property, good biocompatibility and the like when used for treating monilial vaginitis, bacterial vaginitis, mixed vaginitis, cervicitis, cervical erosion and the like of women. The invention also relates to a preparation method and medical application of the chitosan gel for women.

A disinfecting nano silver gel for treating bacterial vaginitis, prostatitis, burn, scald, wound, etc. contains pharmacologically receptable additive, carrier, and broad-spectrum antibacterial nano silver particles (0.1-0.4%) with 1-100 nm of granularity.

The invention relates to a medicinal composition for treating bacterial vaginitis, which comprises main medicaments, substrates, a bioadhesive material, a release rate regulator and other additives. The medicinal composition for treating bacterial vaginitis has specific biological adhesion, keeps longer time, reduces leakage of the medicaments, prolongs the contact time of the medicaments and the vagina mucosa, and guarantees the curative effect. The composition has specific vagina slow release performance, and can continuously release the medicaments for 2 to 7 days. Compared with the common preparation, the medicinal composition prolongs the releasing time of the medicaments, can reduce the administration times, and is convenient for the patient to take. As simultaneously the medicinal composition has the characteristics of biological adhesion and slowly-released long effect, the medicinal composition has no requirement for the administration time, and the administration can be carried out at any time.

The invention aims to provide a combined detection kit for vaginitis, capable of evaluating vaginal micro-ecological environment, vaginal cleanliness, and pathogens of bacterial vaginosis, Candida vaginitis, trichomonas vaginitis of the tested person simultaneously. Ihe following technical scheme adopted by the invention, a combined detection kit for vaginitis is provided and comprises a reaction device, diluent and chromogenic liquid, the reaction device is a hole type box-shaped reaction device with six reacting blind holes, in which a hydrogen peroxide concentration detection reagent pad, a leukocyte esterase detection reagent pad, a neuraminidase detection reagent pad, a proline aminopeptidase detection reagent pad, an acetyl glucosaminidase detection reagent pad and pH detection test paper are arranged respectively. Through the combined detection, the vaginitis caused by most of the BV (Bacterial Vaginosis) pathogens, the Candida albicans and the trichomonas can be detected, BV missing detection caused by the simple detection for one kind of enzyme activity is avoided largely, and the detection reliability and accuracy are increased.

The invention belongs to the technical field of food and health care products, and particularly relates to a quintuplet probiotic composition for improving intestinal tracts. The quintuplet probioticcomposition comprises the following components in parts by weight: 60-65 parts of polyisomaltose, 25-30 parts of maltodextrin, 15-20 parts of erythritol, 10-12 parts of galactooligosaccharide and 11-25 parts of probiotic, wherein the probiotic comprises lactobacillus rhamnosus R0011, lactobacillus helveticus R0052, lactobacillus rhamnosus GG, animal bifidobacterium B94 and bifidobacterium longum R0175. At the same time, the invention provides a composite solid beverage prepared from the quintuplet probiotic composition. Through a scientific strain ratio, gastrointestinal tracts are promoted toabsorb an effective quantity of viable bacteria; intestinal florae are adjusted; uncomfortable symptoms of the gastrointestinal tracts, such as various uncomfortable symptoms of the gastrointestinaltracts after flora disequilibrium due to bacterial infection and antibiotic related diarrhea, are improved; an intestinal environment is adjusted, so that the immunity is boosted; an immunoreaction ofan allergic disease is adjusted fundamentally; a constitution environment of females can also be improved; and bacterial vaginitis is effectively prevented and treated.

The present invention discloses a composite antibacterial gel and a preparation method thereof. The composite antibacterial gel which has highly antibacterial performances is prepared by compositing gelatin, chitosan, amino acid and dimethyl octadecyl[3-(trimethoxysilyl)propyl]ammonium chloride. The composite antibacterial gel can stop bleeding, promote wound healing, has highly antibacterial properties, has a certain effect on treatment of vaginitis (bacterial vaginosis, candida vaginitis, mixed vaginitis, vulvitis) and cervical erosion and other gynecological diseases, and also has the effect of cleaning and nursing female privates, stopping bleeding, killing pain, diminishing inflammation, killing bacteria and promoting wound healing.

The invention provides use and a preparation method of vaginal thermosensitive gel. The use is the use of the vaginal thermosensitive gel in the preparation of medicaments for treating vaginitis including bacterial vaginitis, mycotic vaginitis, mycoplasmal vaginitis, trichomonas vaginitis and senile vaginitis. The vaginal thermosensitive gel of the invention has a pH value in accordance with a vaginal environment, high patient tolerance and long in-vivo duration of more than 20 hours and therefore can reduce dosing frequency, improve patient compliance, strengthen the treatment effect of the medicaments and reduce toxic and side effects. In addition, the temperature of the gel is mild, so the gel has high liquidity before entering bodies and becomes solid after entering the bodies and the administration is convenient and sanitary.

The present invention relates to a pH test glove bearing a reporter substance indicating the possible presence of vaginal affection. such as infections, in particular bacterial vaginosis, or vaginitis. This glove is easy to use, accurate and safe for the woman using it. The present invention also provides packages comprising the glove and gynecological compositions for treating vaginal affections

The present invention is compound preparation for treating womení»s inflammation, and belongs to the field of medicine technology. Each 1000 application units of the compound preparation consists of ornidazole 100-1000 g, butoconazole nitrate 10-500 g and policresulen 50-300 g. The compound preparation may be prepared into different forms, including vaginal suppository, vaginal effervescent tablet, vaginal tablet, vaginal gel, etc. The compound preparation has the functions of resisting anaerobic bacteria, resisting protoplasm, resisting mildew and resisting aerobion, and may be used in treating various womení»s infectious diseases, such as bacterial vaginitis, mycotic vaginitis, protozoal vaginitis, non-specific vaginitis, mixed infectious vaginitis, pruritus vulvae, etc.

The invention relates to sterile cleansing solution for women. The cleansing solution is composed of chitosan with a specific molecular weight and deacetylation degree, chlorhexidine, glycerol, acidifier and purified water. The cleansing solution is applied in the environment with hundred-thousand-level cleanliness, the chitosan and the purified water are mixed to form suspension liquid, acidifier is added in the suspension liquid to adjust the pH value to be within the range from 3.8 to 5.8, and chitosan gel is obtained. The chlorhexidine is additionally taken and is dissolved in the glycerol and is added in the chitosan gel, the chitosan gel is evenly stirred, degasification is conducted, filling sealing is conducted and sterilization is conducted, wherein the acidifier is lactic acid or acetic acid or the mixture of hydrochloric acid and acetic acid, and Co-60 irradiation processing or high-temperature damp and hot sterilization is conducted during the sterilization process. The invention further relates to the manufacturing method of the cleansing solution for curing the gynecological disease and the application of the cleansing solution in preparation of medicines for curing women monilial vaginitis, bacterial vaginitis, trichomonas vaginitis or cervicitis, and the sterile cleansing solution for women can be used for daily hygiene care of the vagina of a woman.

The invention relates to a chitosan gel dropping pill for gynaecologic bacteriostasis and a preparation method thereof. The gel dropping pill comprises the following constituents: compound chitosan with different molecular weights and deacetylation degrees, gelatinizer, acidifier, sodium chloride, purified water and dropping pill matrix. The method comprises the steps of mixing the compound chitosan and aqueous solution of sodium chloride with certain concentration, so as to form suspension, then feeding a proper amount of gelatinizer to the suspension, adjusting the pH value of the suspension through the acidifier, feeding compound chitosan gel obtained into matrix melt, uniformly mixing the compound chitosan gel and the matrix melt, and feeding the compound chitosan gel and the matrix melt into a pill dropping machine to prepare dropping pills, so as to obtain the chitosan gel dropping pill. The chitosan gel dropping pill is good in roundness, rapid in drug dissolution and high in bioavailability, the antibacterial ability of the chitosan gel dropping pill for gram-positive bacteria and gram-negative bacteria reaches greater than 99 percent, and the chitosan gel dropping pill is applied to the curing of monilial vaginitis, bacterial vaginitis, trichomonas vaginitis or cervicitis in gynecology, has good curative effect, high safety and good biocompatibility. The invention also relates to a preparation method and the medical application of the chitosan gel dropping pill.

The invention relates to lactobacillus for inhibiting pathogenic bacteria of vaginitis, wherein the lactobacillus is deposited in the China General Microbiological Culture Collection Center and is selected from a group consisting of Lactobacillus acidophilus with the preserving number CGMCC No.6244, Lactobacillus delbrueckii subsp.Lactis with the preserving number CGMCC No.6245 and Lactobacillus plantarum with the preserving number CGMCC No.6246. The lactobacillus provided by the invention can be attached to vaginal cells of a host, stays in the host body for a long time to generate a good bacteriostatic ability, and can secrete massive hydrogen peroxide to generate oxides which are toxic to vaginal pathogenic bacteria, so that the lactobacillus has excellent bacteriostatic effect to pathogenic bacteria of mycotic vaginitis and pathogenic bacteria of bacterial vaginitis, and can be widely applied to preparing commercial products for treating or preventing infection of pathogenic bacteria of vaginitis, such as health-care products and medical preparations. The lactobacillus provided by the invention can be independently used or mixed with other required components to process and prepare products in various forms so as to effectively control infection of pathogenic bacteria of vaginitis and related diseases caused by pathogenic bacteria of vaginitis.

The invention discloses a rapid detection device, a detection test strip and a detection method for bacterial vaginosis. The rapid detection device for bacterial vaginosis comprises an engine cover, a data processing chip, a delivery mechanism, an optical detection system and a control device, wherein a movable tray with a groove is arranged below the engine cover; and the optical detection system and the control device are arranged in the engine cover. The assorted test strip takes an oblong-shaped nontransparent white thin piece as a film base to which a blank block and detection reaction modules for pH, hydrogen peroxide, leucocyte esterase and sialidase are attached uniformly. The detection device and the test strip of the invention can quantitatively analyze four indexes of bacterial vaginosis at the same time, greatly shorten the test time of the four indexes, make operation more convenient, reduce errors caused by the conventional manual reading and make results more reliable by automated analysis and can be widely applied to the diagnosis and treatment observation of bacterial vaginosis by different levels of clinical institutions.

The invention discloses a method for preparing a human vaginal microecological preparation-probiotics condom. The method is characterized in that probiotics are added to the front end of a condom or a stock solution by adopting the ecology theory of bacteria inhibition through probiotics, so that probiotics are fully and evenly distributed into female vaginas when men and women make love, thus the functions of restoring vaginal flora balance and self-cleaning are achieved; gynecological diseases such as bacterial vaginitis (BV), colpitis mycotica and trichomonas vaginitis are effectively treated and prevented. The method has the advantages that the method that the probiotics enter the vagina to adjust vaginal flora balance is simple and convenient, has both treating and protecting functions, is used for supporting the healthy energy, and is good in treatment effect, free of recurrence after curing, high in efficiency, economical, safe and wide in application range.

The present invention relates to a pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina which comprises sucrose and / to maltose, to the use of certain sucrose and / or maltose, in preparing the pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, in particular to a method of stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, treating the reduction of gram-positive bacilli and the lowness of acidity in vagina as well as the vaginitis and the disturbance of vaginal bacterioflora accompanying the reduction of gram-positive bacilli, especially bacterial vaginal disease.

The invention discloses Lactobacillus johnsonii (Ljohn-1). Through the utilization of a dominant strain belonging to the vaginas of the women in our country and the utilization of applied technologiesthat the dominant strain can be applied to vaginal micro-ecological preparations, the cure rates of bacterial vaginitis can be increased, and the recurrence rates of the bacterial vaginitis can be reduced. The strain has been deposited with the China Center for Type Culture Collection in June, 2019 and assigned the accession number CCTCC No. M 2019426.

The invention discloses a chitosan antibacterial lotion for gynecology, which is a solution prepared through the steps as follows: dissolving chitosan in purified water, and adjusting the pH value to 4.0-6.5, wherein the weight percentage of chitosan in the solution is 0.4-0.6%; the invention further provides a preparation method of the chitosan antibacterial lotion for gynecology. The chitosan antibacterial lotion for gynecology, provided by the invention, is used for treating candida albicans vaginitis, bacterial vaginosis, cervical erosion and other gynecological diseases according to the principles of bacterium resistance and inhibition, and has the effects of inhibiting bacteria, diminishing inflammation, stopping bleeding, relieving pain, ensuring moist wound, reducing percolate of tissues, and promoting healing of the wound.

The invention discloses a composition for adjusting vaginal micro ecological balance and / or treating atrophic vaginitis and application thereof. The composition comprises the following raw materials in parts by weight: 500-10,000 parts of lactose monohydrate, 4.5-50 parts of sodium hyaluronate, 4.5-50 parts of PHMB, 0.45-5 parts of L-lactic acid and 113.4-1250 parts of hydroxypropyl methyl cellulose. By adopting the product disclosed by the invention, growth of vaginal lactobacillus is facilitated, a normal physiological environment of the vagina is maintained, the position of dominant bacteria of the lactic acid bacillus is solidified, pH value of the vaginal environment is recovered, vaginal micro ecological balance of bacterial vaginosis is facilitated, and especially to postmenopausal women, the composition has significant effects on improvement of the symptoms such as ovarian function decline, great estrogen reduction, vaginal wall contraction, thinning mucous membrane, reduction of glycogen content in epithelial cells, pH value rise inside vagina, vaginal dryness and the like, and improvement of vagina functions.

The present invention relates to a novel Lactobacillus sp. isolation strain having an activity to inhibit the growth of vaginitis pathogens, and a pharmaceutical composition, a health functional food, and a cleansing product, comprising the strain as an active ingredient. Therefore, the present invention exhibits an effect of inhibiting the growth of Sneathia spp. pathogens associated with the infection with human papillomavirus (HPV) and the incidence of bacterial vaginitis, Gardnerella vaginalis as a vaginitis pathogen, and Candida albicans as a causative bacteria of Candidal vaginitis, and an effect of recovering and maintaining the vaginal microflora, and thus can be used for the prevention and treatment of female vaginitis.

The invention discloses a matrine-containing vaginal effervescent preparation. The preparation comprises an alkaline inner layer and an acidic outer layer, is used for treating vaginal infection of women and gynecological inflammation caused thereby, has a reasonable formula and cannot cause adverse reactions such as vulvovaginal stimulation symptoms and the like. In addition, the invention also relates to a preparation method and application of the preparation in preparation of medicaments for treating diseases such as bacterial vaginosis, candidal vulvovaginitis and / or trichomonas vaginitis and the like.

The invention discloses a traditional Chinese medicine suppository for treatment of bacterial vaginitis, which is prepared from the following principal raw materials in parts by weight: 1-5 parts of alum, 6-12 parts of mulberry fruit, 5-15 parts of dodder, 6-16 parts of Agratum conyzoides, 2-4 parts of white lip pearl oyster, 5-13 parts of rutaecarpa, 10-20 parts of Chinese prickly ash, 8-20 parts of indigo naturalis, 7-14 parts of wild chrysanthemum, 4-8 parts of rhubarb, 8-14 parts of honeysuckle, 6-15 parts of Sophora. The traditional Chinese medicine suppository provided by the invention mostly is prepared from the medicines capable of clearing heat and removing toxicity, quickly relieving itching, relieving pain and diminishing inflammation, moreover, in the suppository, the medicines with effects of relieving itching, inhibiting bacteria, clearing heat and removing toxicity are combined together, thus, the suppository can thoroughly treat bacterial vaginitis, also can treat gynecologic inflammation, can treat bacterial vaginitis safely and quickly, and currently, is a relatively ideal medicine for treating bacterial vaginitis.

The invention provides a preparation method of a human body lubricant on the basis of a probiotic culture substance. In the technical scheme, probiotics, having beneficial effects on human body, are added to the human body lubricant with uniform mixing under a sterile condition, so that the probiotics are uniformly and fully distributed in vagina of female during use, thereby achieving lubrication effect and recovering microflora balance in vagina. With the flora advantage of the probiotics, colonization rick of other microorganisms is reduced. The human body lubricant effectively prevents and treats bacterial vaginitis, colpitis mycotica, trichomonas vaginitis, and the like gynecological diseases. In addition, in a manner of probiotics entering vagina, the microflora balance is regulated, so that the human body lubricant is convenient to use and has both treatment and prevention functions. A woman can fully enjoy sex and meanwhile is free from bacterial infection. The human body lubricant also can help treatment of different diseases caused by microflora disturbance in vagina, has good treatment effect, is free of relapse after healing, and has excellent promotion prospect.

The invention relates to a gel preparation for treating gynecological diseases. The gel preparation consists of chitosan with specific molecular weight and degree of deacetylation, chlorhexidine, glycerin, an acidifying agent and purified water. The preparation method comprises the following steps of: mixing the chitosan with the purified water to form suspension liquid in an environment with cleanliness at one-hundred-thousand level; adding the acidifying agent to regulate pH to 3.8-5.8 to obtain chitosan gel; dissolving chlorhexidine in the glycerin, adding into the chitosan gel, uniformly stirring, degassing, filling, sealing, and sterilizing to obtain the gel preparation, wherein the acidifying agent is lactic acid, acetic acid or a hydrochloric acid-acetic acid mixture; and the sterilizing mode is cobalt-60 irradiation treatment or high-temperature damp-hot sterilization. The gel has good adhesion force, uniform color and good stability, is used for treating women monilial vaginitis, bacterial vaginitis, mixed vaginitis, cervicitis, cervical erosion and the like, and has the advantages of being good in curative effect, safe, natural, good in biocompatibility and the like. The invention further relates to a preparation method and medical application of the gel preparation.

The invention discloses traditional Chinese medicine sponge for treating bacterial vaginitis. The traditional Chinese medicine sponge for treating bacterial vaginitis is prepared from the following main raw materials in parts by weight: 10-20 parts of green onion, 6-12 parts of mint, 5-15 parts of willow herb, 6-16 parts of lalang grass rhizome, 1-5 parts of golden larch bark, 2-8 parts of cortex phellodendri, 10-20 parts of angelica sinensis, 15-25 parts of polygonum cuspidatum, 8-20 parts of fructus kochiae, 12-25 parts of purslane, 3-14 parts of honeysuckle and 110-150 parts of gelatine. The traditional Chinese medicine sponge disclosed by the invention mainly selects medicines capable of clearing away heat and toxic materials, and rapidly relieving itching, relieving pain and diminishing inflammation; moreover, the traditional Chinese medicine sponge disclosed by the invention combines the medicines capable of relieving itching, inhibiting bacteria, and clearing away heat and toxic materials together, is capable of thoroughly treating bacterial vaginitis and treating gynecologic inflammation, is a medicine for safely and rapidly treating bacterial vaginitis, and is an ideal medicine for treating bacterial vaginitis at present.

The invention discloses a pharmaceutical composition for restoring female vagina microecological balance. Including the following raw materials by weight: 1-5 parts of garlic fructan, 1-5 parts of xylooligosaccharide, 0.2-0.5 part of nano silver, 0.05-2 part of natural lactic acid, 0.1-0.5 part of carotene, 0.1-0.1 part of tea tree oil 1 serving. The pharmaceutical composition of the invention can maintain the physiological environment of the vaginal mucosa, restore the pH value of the vaginal environment, and is beneficial to the balance of the vaginal micro-ecological environment of bacterial vaginosis.

The invention discloses a human body pathological change sensing device belonging to the technical field of clinical diagnosis instruments. Actual operation of diagnosing flora imbalance bacterial vaginosis with Amsel and Nugent standards is difficult; although certain new technology applications exist, the bacterial vaginosis is actually caused by a plurality of intricately interweaved factors; the methods are rough; and the operation is complicated and overloaded. The invention provides a complete, precise and convenient diagnosis method. The device comprises a vaginal chemoreception chip and a handle, wherein the chip consists of a substrate and a tunica; one surface of the substrate is combined with specific detection reagents to form detection units; the detection units are arrayed; the substrate is covered with a thin film; the handle consists of a handle head and a handle tail; the handle head is provided with a groove for placing the chemoreception chip; pits are formed in the middle parts of the two side wings of the substrate; and bulges are arranged at the middle parts of the inner faces on the two sides of the groove. The device and the method have the beneficial effects that more pathogenic factor changes in a vagina can be detected directly; the device is small in size; vaginal secretions are collected without swabs; elution and dilution are avoided; and the device is suitable for bedside operation by an outpatient doctor of a hospital or household use by a patient.

The invention provides a strain(lactobacillus plantarum LP-A3), a screening method, and an application of the strain in the prevention and treatment of mycotic and bacterial vaginitis by regulating the floras in vaginas. The strain is saved in China General Microbiological Culture Collection Center, CGMCC. The address of CGMCC is No.3 building, No.1 yard, Beichen west road, Chaoyang district, Beijing. The preservation number is CGMCC No. 14570. The preservation date is 29th, August, 2017. LP-A3 is separated from secretion of vaginas of strictly selected females; and the research results show that LP-A3 adapts to the environment of vaginas, can reach vaginas through oral administration, has high activity and a strong colonization performance in vaginas, can better adjust the floras in vaginas, and is capable of co-existing with and mutually benefiting other probiotics. The provided bacterial strain can obviously prevent and relieve vaginitis and has a wider application range.

The invention relates to the technical field of application of bacteroides fragilis, and in particular relates to application of bacteroides fragilis in preparation of a composition for treating bacterial vaginitis. The experiments show that bacteroides fragilis is safe and nontoxic and strong in pharmacologic action, and has good treating effect to treat bacterial vaginitis, thereby indicating that the bacteroides fragilis has good edible and medicinal prospects. According to the invention, a novel use of bacteroides fragilis is explored and a novel application field is developed. Bacteroides fragilis as a probiotic can be used for preparing foods or medical compositions for treating bacterial vaginitis.

The invention relates to a probiotic preparation for preventing and treating female diseases and a preparation method and application thereof. The probiotic preparation comprises a powder component and a solution component. The powder component is prepared from, by weight, 1-13% of probiotic compound fungus powder, 2-10% of tara gum, 35%-55% of fructo-oligosaccharide and 35%-55% of galactooligosaccharide. The probiotic compound fungus powder is prepared from lactobacillus rhamnosus R11, lactobacillus reuteri HA188 and lactobacillus helveticus R52. The solution component is prepared from, by weight, 1%-25% of fructo-oligosaccharide, 0.001%-0.01% of citric acid and the balance normal saline. By means of the probiotic preparation, genital tract flora health can be effectively adjusted, and female genital tract infectious diseases such as genital tract bacterial vaginitis, colpitis mycotica, pelvic infection, cervicitis and urinary system infection can be relieved.

The invention discloses clotrimazole cream and a preparation method thereof. The clotrimazole cream comprises components in percentage by mass as follows: 1% of clotrimazole, 17%-34% of oleaginous bases, 4%-6% of an emulsifying agent, 5%-10% of a moisturizer, 1.1%-3% of a preservative, 0.03%-0.05% of a complexing agent and the balance of water. According to the clotrimazole cream, the antibacterial drug clotrimazole with the concentration of 1% is reasonably proportioned with components such as the preservative with antibacterial activity and the like, so that the antibacterial drug plays the important role, can improve the trichomonas killing effect, can be used for treating bacterial vaginitis, trichomonas vaginitis, senile vaginitis, male balanitis, penis itching and the like clinically, and enlarges the treatment range.