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Use and preparation method of vaginal thermosensitive gel

A temperature-sensitive gel and temperature-sensitive gel matrix technology are applied in the fields of polymer materials and preparation to achieve the effects of good fluidity, reduced administration frequency and enhanced therapeutic effect

Inactive Publication Date: 2010-04-21
WUHAN WORLDNER UNITED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention utilizes the characteristics of thermosensitive gel to make thermosensitive gel for vagina, which is used to prepare medicine for treating gynecological inflammation, and solves a series of problems in the prior art of using vaginal solid gel to treat gynecological inflammation

Method used

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  • Use and preparation method of vaginal thermosensitive gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take the temperature-sensitive gel matrix of the present invention, add 0.01% India ink for coloring; take the solid gel of carbomer matrix, add 0.01% India ink coloring as a control group, and inject them into the vagina of mice respectively at 0.5h, 1h, 3h, The mice were killed at 6h, 12h, 16h, and 20h, and the vagina was taken to observe the retention time of the gel in the mice. figure 1 .

[0042] From figure 1 It can be seen that the carbomer-based solid gel is basically emptied after 3 hours of administration, while the temperature-sensitive gel matrix of the present invention can also be observed at 20 hours. Therefore, the residence time in the body is greater than 20 hours, which can achieve once a day treatment aims.

Embodiment 2

[0043] Example 2 Comparative experiment of treating mycoplasma vaginitis with thermosensitive gel for vagina containing 1% turmeric oil and commercially available turmeric oil suppository

[0044] 40 SPF female KM mice were pretreated with hormones, and 30 mice were randomly selected to be inoculated vaginally with Ureaplasma urealyticum (Uu bacterial liquid) every other day, 20ul 2.5×105ccu / ml each time for 7 consecutive days. Construct a mouse model of mycoplasma infection with vaginitis. After successful model building, 10 animals without Uu bacterial liquid were regarded as normal group; 30 animals after inoculation were randomly divided into model group, turmeric oil temperature-sensitive gel group, and turmeric oil suppository group, with 10 animals in each group, administered vaginally. The normal group was given no medication, the model group was given a blank gel matrix, and the zedoary turmeric oil temperature-sensitive gel group and zedoary turmeric oil suppository gro...

Embodiment 3

[0050] Example 3 A comparison experiment on the treatment of fungal vaginitis with a 0.1% vaginal temperature-sensitive gel preparation containing amphotericin B and a commercially available amphotericin B effervescent tablet (0.1%)

[0051] 40 SPF female KM mice, after hormone pretreatment, 30 randomly selected vaginal inoculation of Candida albicans liquid, once every other day, 20 μL of 1×10 each time 8 Cfu / mL, for 7 consecutive days, a mouse model of mold infection with vaginitis was constructed. After successful modeling, 10 animals that were not inoculated with Candida albicans liquid were regarded as the normal group; 30 animals after inoculation were randomly divided into the model group, the amphotericin B temperature-sensitive gel group, and the amphotericin B effervescent tablet group, each with 10 only. Vaginal administration, no administration in the normal group, blank gel matrix in the model group, and corresponding drugs in the amphotericin B temperature-sensitive...

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PUM

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Abstract

The invention provides use and a preparation method of vaginal thermosensitive gel. The use is the use of the vaginal thermosensitive gel in the preparation of medicaments for treating vaginitis including bacterial vaginitis, mycotic vaginitis, mycoplasmal vaginitis, trichomonas vaginitis and senile vaginitis. The vaginal thermosensitive gel of the invention has a pH value in accordance with a vaginal environment, high patient tolerance and long in-vivo duration of more than 20 hours and therefore can reduce dosing frequency, improve patient compliance, strengthen the treatment effect of the medicaments and reduce toxic and side effects. In addition, the temperature of the gel is mild, so the gel has high liquidity before entering bodies and becomes solid after entering the bodies and the administration is convenient and sanitary.

Description

Technical field [0001] The invention relates to a polymer material and a preparation method, in particular to the application of a temperature-sensitive gel for vagina and a preparation method thereof. Background technique [0002] At present, the vaginal preparations commonly used in the treatment of gynecological inflammation mainly include: lotions, suppositories, effervescent tablets, gels, creams, and films. The lotion is a liquid preparation. Although it can flush the vaginal infections, it has poor local anti-inflammatory and bactericidal effects due to the short local action time. The suppository has good local retention characteristics, but its effective local treatment is limited to the vaginal opening 3 -5cm, and the length of the vagina is 8-12cm; the gel can deliver the drug to 8cm in the vagina with the aid of an applicator. However, because the drug is administered in the form of a solid gel, the contact and dispersion of the drug with the patient’s tissue are unev...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61P15/02A61P31/00A61P31/10A61P33/02
Inventor 丁虹高冬梅张瑞陈竹
Owner WUHAN WORLDNER UNITED PHARMA
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