1352 results about "Pathogenic factor" patented technology

Methods to reduce or inhibit populations of pathogenic bacteria in animals are disclosed. These methods include providing a number of administrations of probiotic microorganism compositions containing one or more strains or species of probiotic microorganisms. Routes of administration, dosage of administration and pathogenic organisms to be reduced or inhibited are also disclosed.

The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

The invention relates to pure traditional Chinese medicinal lotion for treating skin diseases, which is prepared from weeping forsythiae, cicada shell, angelica dahurica, common cnidium fruit, belvedere fruit, dandelion, wild chrysanthemum, caulis lonicerae, glabrous greenbrier rhizome, light yellow sophora root, cortex dictamni, Chinese mugwort leaf, amur corktree bark, virgate wormwood herb, red paeony root, salvia miltiorrhiza bunge, borneol and other traditional Chinese medicines. The lotion has the effects of clearing heat, detoxicating, clearing damp, dispeling the wind, relieving itching, cooling blood, invigorating the circulation of blood, diminishing swelling and relieving pain. The lotion is suitable for treating various skin dieases caused by skin invasion of exogenous pathogenic factors including 'wind, damp, heat, toxic and worm', and is particularly applicable to infants with various skin diseases such as eczema, heat rash, diaper rash, milk ringworm, urticaria, cutaneous pruritus, erythema, red spot, dermatitis, papule, herpes, ulcer, furuncle and carbuncle, pruritusani, unknown pyogenic infection, bite by mosquito and worms, jaundice and congenital disease. The lotion is applicable to adults. For example, the lotion can be used for treating female vaginal discharge disease, pruritus genitalium, pruritus ani and other diseases.

The invention relates to a Chinese medicinal feed additive for preventing and treating common diseases of chickens. The Chinese medicinal feed additive is prepared from the following selected raw materials according to parts by weight: radix scutellariae, rhizoma coptidis, golden cypress, milk veteh, fructus forsythiae, honeysuckle, rhizoma belamcandae, rhizoma atractylodis, fried bighead atractylodes rhizome, hawthorn, barley malt, medicated leaven, codonopsis pilosula and liquorice. A preparation method of the Chinese medicinal feed additive comprises the steps of mixing and then grinding the raw materials, or respectively grinding and then mixing the raw materials. The feed additive has the effects of strengthening body immunity to eliminate pathogenic factors, clearing away heat and toxic material, diminishing inflammation and invigorating stomach, sterilizing and disinfesting; by being mixed into daily feed for feeding, the Chinese medicinal feed additive can increase body immunity and disease resistance of chickens; and the feed additive is excellent in preventing and treating such common diseases of chickens as bird flu, new-area plague, salpingitis, white diarrhea, cholera,ascariasis, laryngotracheitis, coccidiosis and colon bacillus. Application proves that the Chinese medicinal feed additive has good preventing and treating effects, easily obtained materials, low cost and no toxic side effect.

The invention discloses nutrient chocolate cookies and a preparation method thereof. The nutrient chocolate cookies are made from the raw materials in parts by weight: 110-120 parts of flour, 30-35 parts of liquid chocolate, 10-20 parts of corn starch, 20-25 parts of powdered sugar, 15-20 parts of palm oil, 10-15 parts of artificial cream, 3-6 parts of whey mist, 2-3 parts of liquid malt extract, 1-2 parts of edible salt, 1-1.5 parts of ammonium bicarbonate, 1-1.5 parts of sodium bicarbonate, 1-2 parts of kudzuvine root, 1-2 parts of hawthorn, 0.8-1 part of dried orange peel, 0.8-1 part of trichosanthes kirilowii leaf, 0.6-0.8 part of rehmannia flower, 0.8-1 part of rhodiola rosea, 0.2-0.4 part of milk cosmetic powder, 0.02-0.04 part of vanillin and 0.01-0.03 part of ferrous lactate. The cookies produced with the method have the characteristics of pure aroma, stable color luster and good mouthfeel; the added kudzuvine root has the effects of activating the yang-energy, expelling pathogenic factors from muscles and skin, promoting eruption, stopping diarrhea, relieving restlessness and lowering temperature; and the rhodiola rosea has the effects of resisting anoxia, resisting fatigue, resisting radiation, resisting tumor, resisting virus, enhancing brain organism and improving myocardial function.

The invention provides a traditional Chinese medicinal composition for treating transmissible gastroenteritis of a swine. The traditional Chinese medicinal composition comprises goldthread, lightyellow sophora root, common aucklandia root, ash bark, tree-of-heaven bark, honeysuckle flower, Chinese pulsatilla root, indian bread, coix seed, Chinese gall, smoked plum, codonopsis, root of hairy asiabell, milkvetch root, Chinese angelica, dried tangerine peel and liquorice root. The traditional Chinese medicinal composition is therapeutically effective for treating the transmissible gastroenteritis of the swine, high in recovery rate, free of any toxic or side effect, phytotoxicity and drug resistance, and low in cost, and can treat both manifestation and root cause of the paradentitis, strengthen body resistance to eliminate pathogenic factors, and improve immunity of the organism and the like. Furthermore, by the aid of the traditional Chinese medicinal composition, the transmissible gastroenteritis of the swine is not prone to relapse.

The invention provides a Chinese traditional medicinal preparation for treating cardiovascular and cerebrovascular diseases, coronary heart disease, headache due to hypertension, tinnitus, deafness, extremity numbness, paralysis, dim sight, palpitation, oppressed feeling in chest, insomnia, etc., particularly a Rongshuangjiangzhi Pill for treating cardiovascular and cerebrovascular diseases. The preparation is prepared from scorpion, centipede, bloodsucker, notoginseng, angelica, ginseng, earthworm, white-stiff silkworm, tall gastrodia tuber, amomun fruit, cinnamon, ground beetle, Chinese wild ginger, borneol, tuber fleeceflower, oriental waterplantain tuber, rhubarb, milk vetch, root of red rooted salvia, chuanxiong rhizome, hawthorn, cyathula root, safflower, cassia seed, burreed tuber, zedoary root and licorice by mixing coarse powder and concentrate extracts proportionally; stirring; drying; pulverizing; sieving; and obtaining capsules. Based on the Chinese traditional medicinal theory for reinforcing body resistance and eliminating pathogenic factors and smoothing blood vessel, the preparation is effective in calming the liver to stop the wind, promoting blood circulation and smoothing collaterals and nourishing yin and tonifying the kidney, and has the advantages of good therapeutic effect, quick effect, safety and no toxicity, and simple formulation and preparation process.

The invention discloses a compound feed used for curing gosling plague and a preparation method of the compound feed, wherein the compound feed comprises the following constituents: corn, wheat, millet, glutinous rice, DDGS, wheat bran, rapeseed meal, green gram starch, lotus root starch, carrots, Chinese yam starch, bombyx batryticatus starch, corn oil, salt, vitamin gunk, and microelement gunk. The preparation method comprises the following steps: a crushing step, a preparing step and a prilling step. The invention has the beneficial effects that the compound feed contains traditional Chinese medicine which is good for a spleen and beneficial for geese to keep a good state, and is antidotal and anti-diarrheal for people; besides, the compound feed can strengthen the body resistance to eliminate pathogenic factors; thus, the compound feed has the advantages that the treatment course is short, the treatment effect is good, no drugs residue, and the cost and the price are low; traditional Chinese additives and other feed raw materials cooperate and interact with each other; not only can the gosling plague be cured, but also the nutritional requirements of goslings can be met, and the compound feed is particularly suitable for meeting the nutritional requirements of the goslings suffering from the gosling plague; moreover, a certain health-care effect for an organism can be achieved after a consumer eats the goose.

The invention relates to a decoction for treating viral myocarditis, which adopts traditional Chinese herbal medicines with cheap price to serve as raw materials, and mainly adopts Chinese medical materials of astragalus mongholicus, ginseng, liriope, roasted schisandra chinensis, root of red-rooted salvia, cassia twig, fried radix paeoniae rubra, white poria cocos, radix glycyrrhizae preparata and the like. A preparation method is simple, and the decoction is obtained by decocting the Chinese medical materials according to the basis principle of strengthening the body resistance to eliminate pathogenic factors and reasonable matching. The decoction for treating the viral myocarditis can meet the requirement of clinical treatment and perform dialectical treatment according to condition of the body, the difference between new and old diseases and the symptom difference of the viral myocarditis, and has remarkable characteristics and advantages of being convenient to take, reasonable in prescription matching and remarkable in curative effect of the viral myocarditis.

The invention discloses a Chinese medicinal preparation for treating infantile upper respiratory tract infection and a preparation method thereof. The Chinese medicinal preparation comprises the following raw material medicaments: Indian buead, ephedra herb, kudzuvine root, white mustard seed, schizonepeta spike, cicada slough, platycodon root, astragalus, gypsum, mint, tangerine peel, divaricate saposhnikovia root, baical skullcap root and heartleaf houttuynia herb. For infants accompanied by sore throat and antiadoncus, watermelon frost and honeysuckle flower are added into the raw material medicaments; for infants accompanied by pyrexia and high fever, weeping forsythia, indigowoad root and gardenia are added into the raw material medicaments; for infants accompanied by poor appetite and indigestion, charred triplet and chicken's gizzard-membrane are added into the raw material medicaments; and for infants accompanied by cough with excessive phlegm, sessile stemona root and unibract fritillary bulb are added into the raw material medicaments. In the Chinese medicinal preparation, pungent warm is matched with acrid cold to dredge sweat pores and cleanse intrinsic heat; and the intrinsic heat is expelled by aiding with pivoting and elevating, and sour-sweet medicaments are subjected to compatibility to nourish yin, clear yingfen and remove the intrinsic heat. The infantile upper respiratory tract infection is caused by exogenous pathogens and seasonal pathogenic factors due to abnormal changes in temperature, and is easy to produce the intrinsic heat, so heat syndromes are common clinically, and quick defervescence is the main treatment aim. The Chinese medicinal preparation has the strong effects of resisting virus, allaying the fever, resisting inflammation and enhancing organism immunity.

The invention provides a traditional Chinese medicinal composition for treating paradentitis. The traditional Chinese medicinal composition comprises anemarrhena rhizome, gypsum, reed rhizome, radices trichosanthis, goldthread, lightyellow sophora root, Chinese pulsatilla root, tree peony bark, largetrifoliolious bugbane rhizome, coix seed, indian bread, lalang grass rhizome, milkvetch root, bighead atractylodes rhizome and liquorice root. The traditional Chinese medicinal composition is therapeutically effective for treating the paradentitis of patients, free of any toxic or side effect and phytotoxicity, and low in cost, and can treat both manifestation and root cause of the paradentitis, strengthen body resistance to eliminate pathogenic factors, comprehensively regulate the body and balance yin and yang. Furthermore, by the aid of the traditional Chinese medicinal composition, the paradentitis is not prone to relapse.

The invention discloses application of a Chinese medicinal composition in preparing a medicament for treating human cases of bird flu. The medicament mainly comprises weeping forsythia, honeysuckle flower, indigowoad root, rhubarb, cablin patchouli herb, male fern rhizome, rhodiola rosea and the like. The medicament has the advantage of global regulating of a compound Chinese medicament, has the effects of expelling pathogenic factors and relieving symptoms, and realizes multi-target treatment. Experiment studies prove that the medicament has remarkable curative effect of treating human cases of bird flu.

The invention discloses stewed shrimps for health care and nourishment having the effects of nourishing yin, strengthening yang and supplementing calcium. The stewed shrimps are prepared by the following steps of: selecting wildly fostered crayfishes and washing the crayfishes with clean water; cleaning the crayfishes; opening backs and removing bowels with a knife for later use; stirring and frying white sugar to be yellowish and pouring blend oil into a pan; putting ginger and seasonings for the health care and nourishment into the pan and stirring the materials slightly over small fire; adding flavorings into the pan; adjusting the fire to be big fire and putting the crayfishes into the pan; introducing the fire to burn the crayfishes to bright red with distilled spirit; adding broth to stew the crayfishes; adding gourmet powder or chicken essence; putting a little shallot and caraway into the pan; and taking the food out of the pan and placing the food in a bowl or a plate. The stewed shrimps for the health care and nourishment having the effects of nourishing yin, strengthening yang and supplementing the calcium overcomes the defect that the conventional crayfishes are usually stirred, cooked, steamed and fried directly so that the nutrition and the nourishment value of cooked crayfishes cannot be enhanced, can clear away harmful and toxic substances generated in the metabolic process of a human body and improve disease resistance of the organism, and has the effects of strengthening yang and blood, nourishing yin and conditioning the temperature, activating blood circulation to dissipate blood stasis, and removing pathogenic factors without any toxic or side effect.

The invention provides a composition consists based on garlic oil, garlic total polysaccharide and garlic total saponin as raw materials. The composition is integrated with water-soluble and fat-soluble effective components of garlic, so that the anti-cancer activity of the garlic is sufficiently played. The composition has excellent anti-tumor activity and has the effects of strengthening body resistance to eliminate pathogenic factors and reducing toxicity, has wide application prospect, and can be prepared into a tumor prevention medicament or health-care product with remarkable curative effect and small toxic or side effect. The invention also provides a method for preparing the composition. The method comprises the following steps: preparing the garlic oil from the garlic through double extraction; preparing garlic total polysaccharide from decoction dreg through water extraction and alcohol precipitation; and carrying out alcohol extraction and macroporous resin purification on the decoction dreg to obtain the garlic total saponin. The preparation method is simple to operate, low in cost and controllable in quality, realizes sufficient utilization of each part of garlic raw materials, and can be industrialized.

An improved method, formulation and kit for the treatment of acne vulgaris are disclosed. The formulation is effective in inhibiting or killing the Proprionibacterium microorganism without utilizing antibiotics A preferred formulation alleviates the four pathogenic factors involved in the development of acne a) the putative pathogen of acne, Proprionibacterium acnes, b) abnormal desquamation of sebaceous-follicle epithelium (comedogenesis), c) the androgen-induced excessive sebum production, and d) the follicular reactivity (inflammation). The formulations are preferably applied as a cream, lotion or an emulsion.

The invention relates to a decalcified dental matrix of a mammal and a preparation method thereof. The raw material is from permanent teeth of the mammal. The preparation method comprises the following steps: (1) collecting permanent teeth of the mammal for later use; (2) soaking the permanent teeth in a 50% 84 disinfectant for sterilizing, wherein the time for sterilizing is 45 minutes and the temperature is 35-40DEG C; (3) removing useless parts of the teeth; (4) smashing tooth tissues into particles; (5) sterilizing the smashed tooth tissue particles, wherein the time for sterilizing is 45 minutes and the temperature is 35-40DEG C; (6) putting the treated tooth tissue particles into 0.65-0.72 equivalent weight of hydrochloric acid liquid for soaking for 10-16 hours at 34-38DEG C to finish decalcification; and (7) drying at low temperature, soaking in hydrogen peroxide for 30 minutes, so as to obtain the decalcified dental matrix of the mammal. The decalcified dental matrix of the mammal has better inductive bone regenerative action, and does not carry any pathogenic factor after being prepared into final products.

The invention relates to the field of molecular biology and medical science, and in particularly relates to a sudden cardiac death mutant gene detection kit which is high in accuracy and good in predictability. The kit is used for performing polymorphism detection on 12 SNP sites of 8 major genes related to sudden cardiac death; three forward and reverse specific primers are respectively adopted for each SNP site by combining the characteristics of specific allelic gene PCR (polymerase chain reaction) and temperature gradient descent PCR; and the mutation of the 12 SNP sites can be simultaneously determined by virtue of program amplification of the temperature gradient descent PCR and agarose gel electrophoretic analysis. The detection kit provided by the invention is strong in specificity, high in detection rate, high in efficiency and low in cost, and can be used for screening high-risk population of sudden cardiac death, evaluating the risk degree of having the sudden cardiac death for a detected patient, and making clear pathogenic factors of patient sudden death from a gene level, thereby providing a new way of preventing, diagnosing and treating clinical sudden death.

The invention discloses a big data based lung cancer screening system and method. The system includes a collection terminal, a server and a man-machine interface. The collection terminal collects dataof lung cancer patients and detection data of patients that need to be screened and uploads all the data. The server is used for receiving the data and the detection data, establishing a lung cancerpatient database on the basis of the data, conducting data analysis on the lung cancer patient database, obtaining relation data between the lung cancer and pathogenic factors, learning and training the relation data to obtain a lung cancer risk predication model, processing the detection data through the lung cancer risk predication model, obtaining reference data between pathogenic factors of the patients that need to be screened and the lung cancer, and sending the reference data to a man-machine interface for display. The beneficial effects are that the relation data of different pathogenic factors and the lung cancer are obtained by conducting big data analysis and counting on the database of the lung cancer patients, so a scientific reference basis is provided for early-stage screening of the lung cancer.

The present invention relates to removing disease causing agent such as pathogens from the blood of a patient. Specifically, the invention relates to using coating materials to trap disease causing agent that is desired to be removed from the blood of a patient. It also related to using lights of specific wavelength to inactivate pathogens. The light is used to activate reactive oxygen species using a photo-sensitizer or directly kill the pathogen using light of wavelength between 100 nm and 450 nm.

The invention discloses a traditional Chinese medicine composition for treating chicken coccidiosis and a preparation method thereof, and belongs to the technical field of veterinary traditional Chinese medicine. The traditional Chinese medicine composition is mainly composed of the following traditional Chinese herbals in parts by weight: 20 to 60 parts of dichroae radix, 20 to 60 parts of hairyvein agrimony, 10 to 30 parts of Chinese pulsatilla root, 10 to 30 parts of purslane, 10 to 20 parts of euphorbia humifusa, 10 to 20 parts of phellodendron, 30 to 90 parts of sweet wormwood, 5 to 15 parts of brucea javanica, 20 to 40 parts of sophora flavescens, 10 to 20 parts of rheum officinale, and 20 to 60 parts of radix astragali. The traditional Chinese herbals are compounded according to the principle of "monarch, minister, assistant and guide" in the traditional Chinese medicine theory. In the formula, dichroae radix, brucea javanica, and Chinese pulsatilla root have the functions of killing and dispelling parasites, clearing heat, removing toxicity, and promoting purgation to remove parasites, and are taken as the monarch drugs; the rheum officinale has the functions of cooling blood, stopping bleeding, promoting purgation, and removing stasis, and is taken as the minister drug; the phellodendron and sophora flavescens have the functions of clearing dampness and heat, dispelling wind, and killing parasites, and are taken as the assistant drugs; the radix astragali has the functions of tonifying middle-jiao and qi, strengthening body resistance to dispel pathogenic factors, and strengthening the immunity, and is taken as the guide drug; and the hairyvein agrimony, euphorbia humifusa, and purslane have the function of astringing to stop bleeding, and are taken as the guide drug too. The traditional Chinese medicine composition is mainly used to treat chicken coccidiosis and has the advantages of reliable curative effect and quick effect.

The invention discloses a Chinese medicine for curing cancer, aiming at solving the problems of unsatisfactory effect and great side effect in the treatment of the cancer in the prior art. The medicine is made from the following Chinese medicine materials: medicated leaven, honeysuckle, tuchahoe, gyrophor, blackgerrykiky rhizome, umbellate pore fungus, parsnip, virgate wormwood herb, radix linderae, angelica dahurica, vietnamese sophora root, sandalwood, asarum, rhizoma zedoariae, Chinese eaglewood wood, cynanchum paniculatum, rhubarb, shell of areca nut, rhizoma paridis, mongolian snakegourdroot, akebia stem, scutellariae barbatae, centipede, scabrous doellingeria rhizome and root, herba lobeliae chinensis, turtle shell, royal jelly, goldthread root, oyster, toad, herba oldenlandiae, fig, clematis chinensis, black nightshade herb, ginseng, thinleaf milkwort root, woody nightshade, radix codonopsitis, radix stemonae, philippine violet herb, angelica, dandelion and coix seed. The Chinese medicine preparation prepared according to such a proposal has the functions of clearing away fever, detoxification, blood activation, bruise curing, softening hardness to dissipate stagnation, supporting healthy qi, removing pathogenic factors, eliminating cancer, etc. and can adjust the immunity, gradually recover the anti-cancer capability, relieve the pain of the sufferers, improve the survival quality and prolong the life of the sufferers.

A titanium dioxide composite having a molecular recognition capacity is obtained by modifying the surface of a fine titanium dioxide particle with a hydrophilic polymer in such a manner that titanium dioxide is bonded via an ester bond to a carboxyl group of the hydrophilic polymer and immobilizing a molecule having an ability to specifically bind to a target molecule to the carboxyl residue of the hydrophilic polymer. Due to the molecule distinguishability, this titanium dioxide complex can bind specifically to an endocrine disrupting chemical, a pathogenic factor, a cancer cell and the like and decompose the same by a photocatalytic function.

The invention discloses an external plaster for pediatric deficiency cold and preparation method thereof. Aim at the physiological and pathological characteristics of children and the pathogenic factors and pathogenesis of pediatric deficiency cold, 8 Chinese crude drugs ccontaining white atractylodes rhizome, clove, chinese magnoliaving, nutmeg and so on, is processed by decocting, condensing, crushing, concocting and the other steps to form plaster. The inventive plaster has functions of invigorating qi and yang, supplementing huo and eliminating han. The principle indications are pediatric deficiency cold, sickness, hiccup, diarrhea, cllic, cough, night cry, enuresis, pale complexion, coldness of the body and limbs, tiredness, inappetence, pale lips, whitish tongue and thin white tongue, etc. The external plaster is safe and convenient in use, with remarkable effect. It solves the probleme of fearing the needle and repelling the drugs of the children, furthermore convenient for controling quality and favourable to large-scale industrialization and continuous production.

The invention discloses a piglet compound feed and a preparation method thereof. The feed comprises the following raw materials: rice, wheat bran, purslane herb, red dates, chestnuts, white hyacinth beans, tomatoes, sticky rice, apples, Chinese yam powder, carrots, a vitamin premix and a microelement premix. The preparation method comprises the following steps: a crushing step, a material preparing step and a granulation step. The piglet compound feed has the beneficial effects that the feed disclosed by the invention contains traditional Chinese medicine additives which have the effects of stopping diarrhea, invigorating spleen to promote digestion, warming yang and tonifying spleen, regulating vital energy and assisting movement, and nourishing yin and resisting loss, and strengthening the body resistance to eliminate pathogenic factors and has the advantages of shorter treatment course, better treatment effect, no medicine residue, low cost and the like; the traditional Chinese medicine additives and other feed raw materials are mutually matched and have mutual action, so that the dyspepsia diarrhea of piglets can be treated and the nutrition requirements of the piglets also can be met; and the piglet compound feed is particularly suitable for the nutrition requirements of the piglets with the dyspepsia diarrhea.

The invention discloses a traditional Chinese medicine for treating psoriasis as well as a preparation method and a quality control method thereof. The traditional Chinese medicine is mainly prepared from the following components: glabrous greenbrier rhizome, chinaroot greenbrier, ash bark, corydalis, honeysuckle, fructus forsythiae, lithospermum, moutan bark, roots of common peony, rehmannia, cape jasmine fruit, scutellaria baicalensis, Chinese rhubarb, turtle shells, Astragalus mongholicus and the like. The quality control method of the traditional Chinese medicine comprises the steps of qualitative determination of the ash bark, the roots of common peony and the cape jasmine fruit and content determination of extracts. The traditional Chinese medicine is mainly used for clearing head, detoxifying and removing dampness and is a product slightly assisting in nourishing yin blood and expelling toxin and pathogenic factors so as to clear heat toxin, remove damp evils and cool blood head of skin mechanisms, thereby achieving the purpose of recovering the normal physiology of the skin mechanisms; and the quality control method ensures the accuracy and the advancement of a quality detection standard of a preparation, can be used for effectively controlling the quality of the preparation and be used as the stability index of a preparation quality control and inspection process.

The invention discloses a traditional Chinese medicine composition, in particular a health-care scent bag and a preparation method thereof. The health-care scent bag comprises a bag body, and a rope is arranged on the bag body. The health-care scent bag is characterized in that medicinal powder is filled in the bag body, and the medicinal powder is prepared from the following components: cassia, galangal, rhizoma kaempferiae, acorus calamus, clove, mugwort leaf, cyrtomium rhizome, camphor, realgar, borneol, menthol and vermilion. The health-care scent bag disclosed by the invention is specially used for preventing communicable diseases such as pestilence, influenza and the like; by properly mixing various medicines and utilizing the synergistic action or resistant action among various medicines, the treatment effect is improved, adverse reactions are reduced, and the treatment effect is obvious; and various medicines are mixed to achieve the purposes of dispelling cold and removing dampness, activating meridians and removing evil, relieving toxicity and killing pests, and eliminating toxic gas and pathogenic factors. By using the traditional Chinese medicine composition for treating 720 patients, the total effective rate reaches 96%.

The invention discloses a rheumatism preparation used for treating rheumatism, mainly solving the technical problems of treating both principal and secondary aspects of rheumatism, especially rheumatism arthritis, and causing rheumatism to be difficult to relapse after healing. The rheumatism preparation comprises the following components in parts by weight: 1-5000 parts of ants, 1-30 parts of scorpions, 1-500 parts of centipedes, 5-500 parts of radix astragali, 1-1000 parts of salvia miltiorrhiza, 1-300 parts of cortex acanthopanacis, 1-100 parts of tree peony bark and 1-100 parts of szechuan lovage rhizome. Compared with the prior art, the rheumatism preparation has the functions of tonifying liver and kidney, strengthening muscles and bones, replenishing qi and blood, expelling wind and removing dampness, reducing phlegm and removing blood stasis as well as dredging collaterals and relieving pain. While remaining all the active ingredients and active substances of the ant raw material, the preparation provided by the invention is directly absorbed and utilized by the human bodies in the form of enzyme, so that the absorption and utilization ratio is improved to more than 80% from 20%, and the preparation bidirectionally regulates the immunity, strengthens body resistance to eliminate pathogenic factors and simultaneously treats different diseases, thus radically achieving the aim of comprehensively treating rheumatism.

The invention relates to methods and kits for assessing the risk, for an individual, of developing an adverse event upon treatment with a therapeutic antibody which is capable of Fab-arm exchange, said method comprising the steps of: a) providing a sample from an individual who is a candidate for treatment with said therapeutic antibody, b) assaying said sample for the presence of circulating IgG4 antibodies that binds an antigen known or suspected to be associated with a causative agent of said adverse event, and c) assessing, on the basis of the outcome of the assay of step b), the risk that the individual will develop said adverse event upon treatment with the therapeutic antibody, wherein the risk of development of said adverse event increases with increased level of said circulating IgG4 antibodies.