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Composition for adjusting vaginal micro ecological balance and/or treating atrophic vaginitis and application thereof

A composition and vaginal technology, which are applied in the directions of drug combinations, non-active medical preparations, anhydride/acid/halide active ingredients, etc., to achieve the effect of increasing pH value, benefiting vaginal micro-ecological environment, and solving genital itching

Active Publication Date: 2014-07-09
NANJING MESE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no preparation for the treatment of senile atrophic vaginitis by regulating the vaginal microecological environment, which is of great significance for improving the quality of life of postmenopausal women

Method used

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  • Composition for adjusting vaginal micro ecological balance and/or treating atrophic vaginitis and application thereof
  • Composition for adjusting vaginal micro ecological balance and/or treating atrophic vaginitis and application thereof
  • Composition for adjusting vaginal micro ecological balance and/or treating atrophic vaginitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 700 mg of lactose monohydrate, 5 mg of prefabricated sodium hyaluronate nanomaterials, 20 mg of PHMB, 0.5 mg of L-lactic acid, and 125 mg of hydroxypropyl methylcellulose. Mix hydroxypropyl methylcellulose and lactose well, soak in a small amount of water overnight, add other ingredients, add water to 5ml, stir and mix evenly, fill, test, and get a gel with a pH of about 3.8 to 4.4.

Embodiment 2

[0035] Take 2000 mg of lactose monohydrate, 10 mg of prefabricated sodium hyaluronate nanomaterials, 20 mg of PHMB, 1 mg of L-lactic acid, and 250 mg of hydroxypropyl methylcellulose. Mix hydroxypropyl methylcellulose and lactose well, soak in a small amount of water overnight, add other ingredients, add water to 5ml, stir and mix evenly, fill, test, and get a gel with a pH of about 3.8 to 4.4.

Embodiment 3

[0037]Take 10,000 mg of lactose monohydrate, 50 mg of prefabricated sodium hyaluronate nanomaterials, 20 mg of PHMB, 5 mg of L-lactic acid, and 1,250 mg of hydroxypropyl methylcellulose. Mix hydroxypropyl methylcellulose and lactose well, soak in a small amount of water overnight, add an appropriate amount of water, stir and mix evenly, fill, test, and get a gel with a pH of about 3.8 to 4.4.

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Abstract

The invention discloses a composition for adjusting vaginal micro ecological balance and / or treating atrophic vaginitis and application thereof. The composition comprises the following raw materials in parts by weight: 500-10,000 parts of lactose monohydrate, 4.5-50 parts of sodium hyaluronate, 4.5-50 parts of PHMB, 0.45-5 parts of L-lactic acid and 113.4-1250 parts of hydroxypropyl methyl cellulose. By adopting the product disclosed by the invention, growth of vaginal lactobacillus is facilitated, a normal physiological environment of the vagina is maintained, the position of dominant bacteria of the lactic acid bacillus is solidified, pH value of the vaginal environment is recovered, vaginal micro ecological balance of bacterial vaginosis is facilitated, and especially to postmenopausal women, the composition has significant effects on improvement of the symptoms such as ovarian function decline, great estrogen reduction, vaginal wall contraction, thinning mucous membrane, reduction of glycogen content in epithelial cells, pH value rise inside vagina, vaginal dryness and the like, and improvement of vagina functions.

Description

technical field [0001] The invention relates to a medical device or medicine directly used in the vagina (administered through the vagina), in particular to a composition for vaginal micro-ecological balance and atrophic vaginitis and its application. Background technique [0002] The vaginal microecological system is composed of vaginal microecological flora, endocrine regulation function and anatomical structure. There is a variety of normal microbial flora in the vagina of healthy women. They restrict and coordinate with the host and the environment to maintain the dynamic balance of the vaginal micro-ecological system. In recent years, with the progress of basic research and the emergence of probiotics, vaginal microecology has received increasing attention. At present, both clinically definite diagnosis and unexplained vaginitis have varying degrees of vaginal microecological imbalance. [0003] The vaginal flora of healthy women undergoes a process of ecological suc...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K47/38A61K47/16A61P15/02A61P29/00A61K31/7016A61K31/19
Inventor 季刚王殿广刘雪陈萍季子为
Owner NANJING MESE PHARMA
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