52 results about "Blood cancer" patented technology

A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.

The present invention relates to heteroaryl compounds comprising nitrogen and use thereof, and more specifically to compounds which exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient.The compounds according to the present invention exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer with a reduced dose compared to that of existing drugs. Accordingly, the compounds can be effectively used for treating various types of cancer, such as uterine cancer, breast cancer, gastric cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, pancreatic cancer, renal cancer, prostate cancer, bladder cancer, and liver cancer, and for inhibiting proliferation of cancer cells and metastasis of cancer.

The invention discloses an application of a compound as a JAK-STAT3 signal passage inhibitor, and particularly relates to an application of a compound with a formula I or pharmaceutically acceptable salt of the compound in the process of preparing an anti-tumor medicament. The application provides a novel treating candidate medicament for a tumor patient, thereby probably further improving the treatment effect on the patient and improving the prognosis of the patient. The compound with the formula I or the pharmaceutically acceptable salt of the compound has the effect on various tumor cells, which indicates that the compound can be used for treating various cancers including cerebral tumor, genitourinary system tumor, lymphatic system tumor, stomach cancer, laryngeal cancer, nasopharyngeal cancer, skin cancer, bone cancer, blood cancer, leukemia, breast cancer and histiocytic lymphoma, non-small cell lung cancer, small-cell lung cancer, lung adenocarcinoma, lung squamous cell cancer, pancreatic cancer, prostatic cancer, liver cancer, epithelial cell cancer and the like. The definition of genes in the formula refers to description for details.

The present invention relates to the use of a compound of formula 3 or a salt thereof for preparing a medicament or a phototherapeutic agent for the treatment of the following diseases, including: acne; AIDS; viral hepatitis; diabetic retinopathy; atypical pneumonia virus infection; coronary Arterial stenosis; carotid artery stenosis; intermittent claudication; Asian (chicken) avian influenza virus infection; cervical dysplasia or various cancers including: blood cancer, cervical cancer, nasopharyngeal cancer, tracheal cancer, laryngeal cancer, bronchial cancer , bronchiolar cancer, bladder cancer, esophagus cancer, stomach cancer, rectal cancer, colon cancer, prostate cancer, hollow organ cancer, bile duct cancer, urinary duct cancer, kidney cancer, uterine cancer, vaginal cancer and other gynecological adnexal cancers. The present invention also relates to methods of treating the above diseases. The present invention further relates to the use of a compound of formula 3 or a salt thereof for the preparation of a photodiagnostic agent for the detection of the above-mentioned diseases and diseases including: atherosclerosis, multiple sclerosis, diabetes, arthritis, rheumatism Arthritis, fungal infection, viral infection, chlamydia infection, bacterial infection, or parasitic infection, HIV infection, hepatitis, herpes simplex, shingles, psoriasis, cardiovascular disease and skin disease. The present invention also relates to methods of detecting the above diseases using photodiagnostic agents. The present invention further relates to a method of cryogenically sterilizing a surgical device or other device, comprising the steps of: providing a compound of formula 3 or a salt thereof on the device; subjecting the device to radiation treatment or sonication. The present invention further relates to a compound of formula 3 or a salt thereof linked or attached to a magnetic element. This compound acts as an MRI enhancer. The present invention also relates to the use of such MRI enhancers for performing MRI scans.

Use of (pyrophosphato)platinum(II) or (pyrophosphato)platinum(IV) complexes (“phosphaplatin compounds”), especially (R,R)1,2-cyclohexanediamine-(dihydrogen pyrophosphato)platinum(II) (or “PT-112”), as therapeutic agents for treatment of bone and blood cancers, or cancers that metastasize to bones, and methods thereof, are disclosed.

The invention discloses a medicine for curing malignant tumor. The medicine is prepared by using the following components according to the following proportions by weight: 8 to 12 parts of cat skull, 95 to 105 parts of oyster shell whiting, 18 to 22 parts of alum, 4 to 6 parts of musk, 8 to 12 parts of borneol, 4 to 6 parts of calomeas and 9 to 11 parts of minium. The medicine with a great power to kill malignant tumor cells is prepared by using the traditional Chinese medicines according to a formula. The medicine has a good effect in curing the malignant rumor ranging from phase I to phase IV, except blood cancer and bone cancer; the course of treatment is short; the cure rate is high; and the relapse rate is low. No operation is needed so that pains brought by the operation to a sufferer are avoided; no chemo-treatment, radiation treatment or other treatment is needed so that side effects brought by the chemo-treatment and the radiation treatment to the sufferer are avoided; no hospitalization is needed so that high hospitalization cost is avoided.

Investigation on the frequency of FLT3 / ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3 / ITD in the blood cell lines revealed that the tyrosine residues in FLT3 / ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3 / ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3 / ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3 / ITD functions as an index.

The present invention relates to: a novel antibody or an antigen-binding fragment thereof for use in the treatment of cancer by targeting B cell malignancies; a chimeric antigen receptor comprising the same; and uses thereof. The antibody of the present invention is an antibody specifically binding to CD19 highly expressed in cancer cells (particularly, blood cancer) and has very low homology compared to the CDR sequences of conventional CD19 target antibodies, and thus the sequence thereof is unique. In addition, cells expressing a chimeric antigen receptor comprising an anti-CD19 antibody orantigen-binding fragment of the present invention induce immune cell activity in response to a positive cell line expressing CD19, and thus can be usefully used as a therapeutic agent for CAR-immunecells.

The present invention provides a compound for treating tumors and its application, and provides the compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound provided by the invention has high drug peak concentration, high drug absorption and long elimination half-life, which can improve the drug efficacy in clinical use and reduce the frequency of administration. The compound prepared by the present invention or a pharmaceutically acceptable salt thereof can be used as a PARP inhibitor drug, and has certain antitumor activity, especially for triple negative, primary or metastatic breast cancer, colon cancer, uterine cancer, Pancreatic cancer, lung cancer, gastric cancer, blood cancer, melanoma, solid tumor or intracranial tumor have good therapeutic activity, which provides a new option for clinical drug use.

The invention relates to coarse cereal biscuits having special treatment effects on treatment of blood cancer (leukaemia) and lymphosarcoma and having the efficacy of nourishing the brain. The coarsecereal biscuits comprise a cephalotaxus fortunei concentrated solution, wheat flour, white granulated sugar, oat flour, peanut powder, apricot kernel powder, walnut powder, vegetable oil, fructus perillae oil, celery seed oil, fresh hen eggs, sorghum flour, buckwheat powder, pumpkin powder, konjac fine powder, mung bean powder, fresh henon bamboo leaves, fresh cream, baking soda, salt and an appropriate amount of water. According to the coarse cereal biscuits provided by the invention, the usage amount of fat is reduced, and a large quantity of coarse food grain components are added, so that nutrient components of the biscuits can be enriched, after being eaten for a long term, the coarse cereal biscuits can adjust the stomach, and besides, the coarse cereal biscuits have certain effects of reducing internal heat and reducing blood pressure; the henon bamboo leaf components are added to the biscuits, so that the taste of the biscuits can be improved, the coarse cereal biscuits have theefficacy of improving sleep, and the nutrient value of the biscuits can be increased; and the cephalotaxus fortunei concentrated solution is added, so that products have multiple medical care health-care effects of preventing cancer, resisting cancer, resisting irradiation, reducing blood lipid and blood sugar, resisting ageing and the like.