Powder mixing technology for compound antibiotic
An antibiotic and powder mixing technology, applied in the field of medicine, can solve the problems of lack of universal applicability and difficulty in ensuring the uniformity of powder mixing, and achieve the effects of good uniformity, low cost and fast dissolution speed.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0028] Preparation of Mezlocillin Sodium / Sulbactam Sodium Mixed Powder
[0029] At room temperature, the powders of mezlocillin sodium (56.1 g, 0.1 mol) and sulbactam sodium (25.5 g, 0.1 mol) were mixed evenly. Control the temperature at 0-5°C, add the above-mentioned mixed mezlocillin sodium / sulbactam sodium powder to 220mL water for injection, add sodium bicarbonate to adjust the pH of the feed solution to 6.37, and filter it through a 0.22μm filter membrane into a freeze-drying box middle. Cool down to -45°C in 2-3 hours and keep for 2 hours. Turn on the vacuum and reach 0.10-0.30mbar for vacuum drying, maintain for 2 hours, then increase the set temperature to 10°C, maintain for 3 hours, increase the set temperature to 40°C, and maintain for 12 hours to completely sublimate the water. The temperature was raised to 55° C. and dried for 10 hours, and the detected moisture was 0.76%. Naturally cool down to room temperature to obtain the product. After testing, the homogen...
Embodiment 2
[0031] Preparation of Amoxicillin Sodium / Sulbactam Sodium Mixed Powder
[0032] At room temperature, the powders of amoxicillin sodium (38.7 g, 0.1 mol) and sulbactam sodium (25.5 g, 0.1 mol) were mixed evenly. Control the temperature at 0-5°C, add the above mixed amoxicillin sodium / sulbactam sodium powder to 180mL water for injection, add sodium bicarbonate to adjust the pH of the feed solution to 6.32, and filter it through a 0.22μm filter membrane into a freeze-drying box middle. Cool down to -45°C in 2-3 hours and keep for 2 hours. Turn on the vacuum and reach 0.10-0.30mbar for vacuum drying, maintain for 2 hours, then increase the set temperature to 10°C, maintain for 3 hours, increase the set temperature to 40°C, and maintain for 12 hours to completely sublimate the water. The temperature was raised to 55° C. and dried for 10 hours, and the detected moisture was 0.73%. Naturally cool down to room temperature to obtain the product. After testing, the uniformity, stabi...
Embodiment 3
[0034] Preparation of Cefoperazone Sodium / Sulbactam Sodium Mixed Powder
[0035] At room temperature, the powders of cefoperazone sodium (66.7 g, 0.1 mol) and sulbactam sodium (25.5 g, 0.1 mol) were uniformly mixed. Control the temperature at 0-5°C, add the above-mentioned mixed cefoperazone sodium / sulbactam sodium powder to 260mL water for injection, add sodium bicarbonate to adjust the pH of the feed solution to 6.42, and filter it through a 0.22 μm filter membrane into a freeze-drying box. Cool down to -45°C in 2-3 hours and keep for 2 hours. Turn on the vacuum and reach 0.10-0.30mbar for vacuum drying, maintain for 2 hours, then increase the set temperature to 10°C, maintain for 3 hours, increase the set temperature to 40°C, and maintain for 12 hours to completely sublimate the water. The temperature was raised to 55° C. and dried for 10 hours, and the detected moisture was 0.71%. Naturally cool down to room temperature to obtain the product. After testing, the homogene...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com