Oral preparation containing cefoperazone schubatain and its making method

A technology of cefoperazone and preparation, applied in the field of therapeutic drugs and preparation thereof, can solve the problems of long time to reach effective blood drug concentration, inconvenient use of injections, easy to cause local pain reactions and the like

Inactive Publication Date: 2007-04-04
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the inconvenient use of injections and the tendency to cause local pain reactions when administered, the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood drug concentration of the drug in the lesion is low, and the effective blood drug concentration in the lesion is reached. The time is also longer, affecting its effective antibacterial efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 - Cefoperazone Sulbactam Candy

[0059] Prescription: cefoperazone sodium 62.5g, sulbactam sodium 62.5g, sucrose 853g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g, preparation dose 1000 tablets.

[0060] Method: Prepare 62.5g of cefoperazone sodium, 62.5g of sulbactam sodium, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P. Grind and pass through a 20-mesh sieve. Take 853 grams of sucrose, heat to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, put it on a product forming machine and extrude, each lozenge weighs 1 gram. Then measure the disintegration time limit of cefoperazone sulbactam candy in 37 ℃ 900ml water and the dissolution rate when completely disintegrating.

[0061] Results: The disintegration time limit is 4-9 minutes, and the dissolution rate when completely disintegrated is 95%-101%.

Embodiment 2

[0062] Embodiment 2-low sugar cefoperazone sulbactam candy (1)

[0063] Prescription: cefoperazone sodium 62.5g, sulbactam sodium 62.5g, sucrose 203g, fructooligosaccharides 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g , preparation dose 1000 tablets.

[0064] Method: Prepare 62.5g of cefoperazone sodium, 62.5g of sulbactam sodium, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P. Grind and pass through a 20-mesh sieve. Take 203g of sucrose, 300g of fructooligosaccharide, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, cool to 85°C, add 62.5g of sieved cefoperazone sodium and 62.5g of sulbactam sodium, and stir quickly After 10 minutes, it is placed on a product forming machine and extruded, and each lozenge weighs 1 gram. Then measure the disintegration time limit of cefoperazone sulbactam candy in 37 ℃ 900ml water and the dissolution rate when completely dis...

Embodiment 3

[0066] Embodiment 3-low sugar cefoperazone sulbactam buccal tablet (1)

[0067] Prescription: Cefoperazone Sodium 62.5g, Sulbactam Sodium 62.5g, Gelatin 240g, Glycerin 60g, Water 60g, Fructose-oligosaccharide 133g, Xylitol 300g, Inulin 50g, Citric Acid 10g, Food Coloring-40 0.1g, Mannitol 10g , Magnesium Stearate 10g, Carbomer 934P 2g, the dosage is 1000 tablets.

[0068] Method: prepare gelatin 240g, glycerin 60g, water 60g mixed matrix, dry, then add cefoperazone sodium 62.5g, sulbactam sodium 62.5g, fructooligosaccharide 133g, xylitol 300g, inulin 50g, citric acid 10g, food coloring -40 0.1g, mannitol 10g, carbomer 934P 2g mixture, grind, pass through a 20-mesh sieve, granulate with ethanol and water, dry at 60°C, then add 10 grams of magnesium stearate, mix well, place into tablets Extruded on the machine, each lozenge weighs 1 gram. Then the disintegration time limit and the dissolution rate of the cefoperazone-sulbactam buccal tablet in 900ml water at 37°C and complete...

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Abstract

An orally absorbed medicine in the form of buccal lozenge, sweets, or dripping pill dissolved by saliva features that it contains cefoperazone and sulbactam. Its preparing process is also disclosed.

Description

[0001] [Technical field] The present invention relates to a kind of therapeutic medicine and its preparation method, especially the buccal preparation containing cefoperazone and sulbactam and its preparation method. [Background technique] [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused b...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/20A61K9/48A61K31/546A61K31/43A61P31/04
Inventor 刘凤鸣
Owner 刘凤鸣
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