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A kind of composition of cefoperazone sulbactam sodium and lysine

A technology for cefoperazone-sulbactam sodium and cefoperazone sodium is applied in the field of the composition of cefoperazone-sulbactam sodium and lysine, which can solve the problems of poor stability, accumulation, and aggravating kidney damage of cefoperazone sodium, and achieve good kidney safety. Sexuality, improve curative effect, good stability effect

Active Publication Date: 2011-12-07
BEIJING SIHUAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this compound preparation, because sulbactam is cleared through the kidneys, clinical studies have confirmed that in patients with renal impairment, the clearance rate of sulbactam is significantly reduced, which is likely to cause accumulation in the body and aggravate the damage to the kidneys. control
In the course of clinical application, for patients with severe infection who need a larger dose, the dose of sulbactam limits its application to a certain extent
[0006] At the same time, cefoperazone sodium has poor stability and needs to be stored in a dry and cold place, and the storage conditions are strict; while the compound preparation of cefoperazone sodium and sulbactam sodium has not greatly improved its stability

Method used

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  • A kind of composition of cefoperazone sulbactam sodium and lysine
  • A kind of composition of cefoperazone sulbactam sodium and lysine
  • A kind of composition of cefoperazone sulbactam sodium and lysine

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Embodiment Construction

[0083] The above-mentioned content of the present invention will be further described in detail through specific implementation in the form of examples below. However, it should not be construed that the scope of the above-mentioned subject matter of the present invention is limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0084] Embodiment The preparation of the composition powder injection preparation of cefoperazone sulbactam sodium and lysine of the present invention

[0085] 1. Prescription

[0086] Prescription 1

[0087] Cefoperazone sodium (in C 25 h 27 N 9 o 8 S 2 Count) 1000g

[0088] Sulbactam sodium (in C 8 h 11 NO 5 S meter) 500g

[0089] Lysine 250g

[0090] Disodium hydrogen phosphate 15g

[0091] Sodium dihydrogen phosphate 94g

[0092] So...

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to a composition of cefoperazone sulbactam sodium and lysine, and also provides a preparation method of the composition injection, and is used for the treatment of cefoperazone drug-resistant patients. Use in medicine for infectious diseases caused by β-lactamase-producing bacteria sensitive to this product.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition of cefoperazone sulbactam sodium and lysine, and the composition is used in the preparation of cefoperazone drug-resistant but sensitive to this product to produce β- Drug application for infectious diseases caused by lactamase bacteria. 2. Background technology [0002] Humans have invented a large number of antibacterial drugs and put them into clinical application. However, due to the long-term and extensive use of antibiotics, the drug resistance of bacteria develops rapidly, and drug-resistant strains continue to be produced. Among them, drug resistance caused by β-lactamase The most serious, has become a major problem in clinical treatment. [0003] Cefoperazone (cefoperazone) is a third-generation semi-synthetic cephalosporin antibiotic, which produces a bactericidal effect on a variety of bacteria by inhibiting the synthesis of bacterial cel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/16A61P31/04A61K31/546A61K31/43A61K9/19
Inventor 车冯升郭维城贾中新霍彩霞孟宪慧
Owner BEIJING SIHUAN PHARMA
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