Powder injection composed of sodium cefoperazone and potassium clavulanate

A technology of powder injection and cefoperazone for injection, which is applied in the field of new compound preparations of cefoperazone sodium, can solve the problems of inability to be used alone, poor antibacterial activity of potassium clavulanate and the like, and achieve the effect of reducing the antibacterial effect

Inactive Publication Date: 2005-08-24
苏大阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, potassium clavulanate has very poor antibacterial activity and cannot be used alone; currently it is mainly used clinically in combination with amoxicillin and ticarcillin for the clinical treatment of various moderate and severe infections and drug-resistant strains of infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] 1. Formula:

[0012] Cefoperazone sodium (calculated as cefoperazone) 0.5kg

[0013] Potassium clavulanate (as clavulanic acid) 0.5kg

[0014] A total of 1000 bottles

[0015] 2. Preparation method:

[0016] Take the formulated amount of cefoperazone sodium and clavulanate potassium under clean conditions, mix uniformly under the conditions of temperature 22±2°C and relative humidity 40±5%, and put them into dry and sterilized antibiotic bottles under the same conditions. Add appropriate amount of water for injection to dissolve before use.

Embodiment 2

[0018] 1. Formula:

[0019] Cefoperazone sodium (calculated as cefoperazone) 0.8kg

[0020] Potassium clavulanate (as clavulanic acid) 0.4kg

[0021] A total of 1000 bottles

[0022] 2. Preparation method:

[0023] Take the formulated amount of cefoperazone sodium and clavulanate potassium under clean conditions, mix uniformly under the conditions of temperature 22±2°C and relative humidity 40±5%, and put them into dry and sterilized antibiotic bottles under the same conditions. Add appropriate amount of water for injection to dissolve before use.

Embodiment 3

[0025] 1. Formula:

[0026] Cefoperazone sodium (calculated as cefoperazone) 0.8kg

[0027] Potassium clavulanate (as clavulanic acid) 0.2kg

[0028] A total of 1000 bottles

[0029] 2. Preparation method:

[0030] Take the formulated amount of cefoperazone sodium and clavulanate potassium under clean conditions, mix uniformly under the conditions of temperature 22±2°C and relative humidity 40±5%, and put them into dry and sterilized antibiotic bottles under the same conditions. Add appropriate amount of water for injection to dissolve before use.

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PUM

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Abstract

A powder injection for treating bacterium-infectious diseases is prepared from cefoperazone sodium and potassium clavulanate in weight ratio of (1-16):1.

Description

technical field [0001] The present invention relates to a new compound preparation of cefoperazone sodium capable of treating bacterial strains producing β-lactamase (including producing extended-spectrum β-lactamase), and further relates to a powder for injection composed of cefoperazone sodium and potassium clavulanate . technical background [0002] Cefoperazone Sodium (Cefoperazone Sodium) is a third-generation cephalosporin (belonging to β-lactam antibiotics), which has broad-spectrum antibacterial effect. It has good antibacterial effect on Pseudomonas, but is stable to most β-lactamases. Poor sex. In recent years, due to the widespread emergence of clinical β-lactamase-producing strains, especially the emergence of extended-spectrum β-lactamase, the resistance rate of cephalosporin antibiotics has been rising, which has seriously affected the clinical anti-infection treatment. . [0003] Clavulanate Potassium (Clavulanate Potassium, also known as potassium clavulan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/546A61P31/04
Inventor 苏大阳张淑华
Owner 苏大阳
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