Method for determining content of cefoperazone sodium of cefoperazone sodium and tazobactam sodium for injection

A technology of cefoperazone sodium and tazobactam sodium, which is applied in the field of medicine and biology, can solve the problems of poor sensitivity and accuracy, complex and troublesome determination methods, etc., and achieve the effect of ideal sensitivity and accuracy and simple method

Inactive Publication Date: 2014-12-10
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

[0004] At present, the methods for determining the content of cefoperazone sodium in cefoperazone sodium and tazobactam sodium for injection are relatively complicated and cumbersome, and the sensitivity and accuracy are not very good.

Method used

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Embodiment 1

[0018] The cefoperazone sodium content assay method of cefoperazone sodium tazobactam sodium for injection comprises the following steps:

[0019] (1) Prepare buffer solution, solution to be tested, cefoperazone sodium reference solution, tazobactam sodium reference solution;

[0020] (2) Take the solution to be tested and place it in the electrolytic cell of the electrochemical workstation. A three-electrode system is adopted, with a glassy carbon electrode as the working electrode, a saturated silver-silver chloride electrode as the reference electrode, and a platinum wire electrode as the auxiliary electrode. After 5 minutes, stand still for 6 seconds, perform differential pulse scanning at -0.6-1.5v, use blank buffer solution to measure the curve for background correction, and determine the content of cefoperazone sodium.

[0021] The buffer solution is prepared as follows: Weigh 3.9 g of sodium dihydrogen phosphate, dilute to 100 mL with deionized water, and store at 4°C....

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Abstract

The invention discloses a method for determining the content of cefoperazone sodium of cefoperazone sodium and tazobactam sodium for injection. A differential pulse voltammetry is adopted to scan the cefoperazone sodium and tazobactam sodium and can accurately quantify the cefoperazone sodium by the obtained peak current value. The method is simple and rapid and can achieve ideal sensitivity and accuracy.

Description

[0001] technical field [0002] The invention relates to the field of medical biology, in particular to a cefoperazone sodium content determination method of cefoperazone sodium and tazobactam sodium for injection. Background technique [0003] Cefoperazone is a third-generation cephalosporin antibiotic that achieves bactericidal effect by inhibiting the biosynthesis of sensitive bacterial cell walls. Tazobactam has no antibacterial activity against other bacteria except Neisseriaceae and Acinetobacter, but tazobactam has activity against most important β-lactamases produced by β-lactam antibiotic-resistant strains Irreversible inhibition. Tazobactam can prevent drug-resistant bacteria from destroying penicillins and cephalosporins, and tazobactam has obvious synergistic effects with penicillins and cephalosporins. Since tazobactam can bind to certain penicillin-binding proteins, sensitive strains may be more sensitive to this compound preparation than cefoperazone alone. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30G01N1/28
Inventor 包莹刘萍陈继源
Owner SICHUAN PHARMA
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