The invention discloses an efficient controlled release fertilizer used for pollution-free fruit mulberries. The efficient controlled release fertilizer comprises, by weight, oyster shells, polylactic acid, graphene, activated nano zeolite, marine microalgae slag, selenium and germanium-enriched spirulina slag, chlorella slag, kelp slag, bacillus subtilis, saccharomycetes, ferrous sulfate, boric acid, calcium ammonium nitrate, soy isoflavone, ammonium stearate, ammonium molybdate, ferrous sulfate, a proper amount of hydrogen peroxide, a proper amount of ammonia water and a proper amount of water. According to the efficient controlled release fertilizer, the marine microalgae slag, the selenium and germanium-enriched spirulina slag, the chlorella slag and the kelp slag are adopted to be matched with nutrient substances, and the coated controlled release fertilizer is prepared after enzymolysis and zymotechnics. The fertilizer is rich in fermentation micromolecule organic matter and microelements, the nutrition is rich and can be absorbed and utilized by the fruit mulberries conveniently, and growth of the fruit mulberries can be facilitated. The selenium and germanium nutrition is increased, and pollution-free cultivation of the fruit mulberries is guaranteed. A coating layer capable of supplying oxygen and dynamically adjusting pores is adopted, organic matter nutrients can be released for a long time, efficient cultivation of the fruit mulberries can be realized, and the efficient controlled release fertilizer can be widely applied and popularized.