33results about How to "Retain pharmacological activity" patented technology

The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

The present invention provides method and compositions for the treatment of peripheral neuropathic pain by administering to a patient a therapeutically effective amount of a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, and wherein the spacer is bonded to the two opioid molecules via an ether bond. Preferably, the active agent is provided in the form of an injectable depot.

A Ganoderma lucidum dendrobium suspension and a preparation method thereof. A ganoderma dendrobium suspension, the mass percentage of each component is: 20-30% of ganoderma extract powder, 65-75% of dendrobium candidum extract, 4.98-4.99% of water, 0.01-0.02% of sweetener, the The preparation method of the suspension: Ganoderma lucidum fruiting body pulverization, supercritical CO 2 Extract to remove fat-soluble impurities, extract with ethanol, filter, concentrate and dry and ultrafinely pulverize to obtain Ganoderma lucidum extract powder; freeze-dry Dendrobium candidum, extract at low temperature, and centrifuge the extract to obtain Dendrobium candidum extract; Ganoderma lucidum extract powder Suspending with Dendrobium candidum extract, dissolving the sweetener in water, mixing the water with the suspension, and aseptically filling to obtain a finished product. The content of Ganoderma lucidum triterpene acid in the finished product is ≥30mg / mL, and the content of polysaccharides is ≥35mg / mL. The invention uses Ganoderma lucidum as the functional component and antibacterial agent, and Dendrobium candidum as the functional component, suspending agent and corrective agent, and the finished product has good stability, good taste and no bitter taste.

The invention relates to a waste treatment method, in particular to a method for simultaneously extracting polysaccharide and flavone from phellinus igniarius sporophore cultivation waste. The method includes the steps: drying the phellinus igniarius sporophore cultivation waste, crushing the dried phellinus igniarius sporophore cultivation waste to obtain dry phellinus igniarius sporophore cultivation waste powder, and mixing the day powder and alkaline ethanol solution; ultrasonically treating the mixed solution for 20-40 minutes, and filtering to obtain filter solution and residues; adding deionized water into the residues, uniformly mixing, adjusting a pH (potential of hydrogen) value to be 4-6 to obtain mixed solution, adding compound enzyme, performing enzymolysis at the temperature ranging from 45 DEG C to 55 DEG C, and centrifuging the enzymolysis solution to obtain supernatant solution and sediments; rotatably evaporating filter solution to remove ethyl alcohol, adding ethyl acetate, extracting, separating solution, and performing pressure reduction, concentration and drying for upper layer solution to obtain phellinus igniarius sporophore flavone; performing pressure reduction and concentration for the obtained supernatant solution by the aid of a rotary evaporator, and performing alcohol precipitation and centrifugation to obtain supernatant solution and sediments. The sediments are phellinus igniarius sporophore polysaccharide.

The invention relates to ganoderma lucidum refined polysaccharides with significant assistant antitumor activity and a preparation method and application of the ganoderma lucidum refined polysaccharides. The refined polysaccharides is heteropolysaccharide which is mainly prepared from mannose, glucosamine, glucuronic acid, glucose, galactose, xylose and fucose in a molar ratio of (3 to 4) to 1 to(1.3 to 1.7) to (56 to 65) to (4 to 6) to (1.3 to 1.8) to (2.5 to 3.5), the absolute purity is greater than 52%, the weight average molecular weight is 7500-8500D, and the molecular weight distribution index is 1.3 to 1.5. The preparation method comprises the following steps of dynamically extracting by hot water, coarsely filtering to remove residues, carrying out fine filtration and clarifying,deproteinizing and decoloring by in-series resin beds, concentrating and removing impurities by an ultrafiltration membrane, and carrying out spray-drying or alcohol precipitation air drying. The method is intelligent and energy-saving, can solve industrial difficult problems, and has significant large scale advantage and good product safety, effectiveness, controllability and stability. The polysaccharides have significant functional activity in assisting in antitumor and are useful for the development of drugs for prevention and treatment of tumors and the development of food and health products in related fields.

The present invention discloses the pharmaceutical use of aconine. Aconine has obvious effects of relieving pain, raising blood pressure, stimulating heart, strengthening cardiac contractility, diminishing inflammation, etc. and is used in preparing analgesic, anesthetic, drug addiction eliminating medicine and fatigue eliminating medicine. Aconine has the same pharmaceutical activity of aconitine but 2000 times lower toxicity and is pharmaceutically safe and reliable. Various aconine preparations has high curative effect, high safety, no dependence and excellent application foreground.

The invention relates to a processing method of cornua cervi pantotrichum through drying. The cornua cervi pantotrichum comprises sika deer and red deer. The method is characterized by comprising the following steps of (1) harvesting; (2) quick-freezing; (3) storing; (4) carrying out high-temperature treatment; or carrying out high voltage pulse electric field treatment; (5) boiling and frying; (6) returning water and drying; (7) air drying and boiling heads. According to the processing technology provided by the invention, an ultra-high pressure processing technology and a quick-freezing technology are mainly utilized to be combined with a traditional cornua cervi pantotrichum processing and drying process, so that fat soluble active ingredients in the cornua cervi pantotrichum can be effectively retained through the process. The processing method is simple in steps, convenient to operate, and high in practicability.

The invention discloses a method for simultaneously extracting polysaccharides and flavonoids from mulberry leaves. According to the method, little equipment is adopted, the reaction condition is gentle, the cost is low, the production is safe and reliable, the product purity is high, the yield is high, and the physiological and the pharmacological activity of the polysaccharides and the flavonoids from the mulberry leaves can be kept relatively well, so that the application value is relatively great,. The polysaccharides, the flavonoids, sorbitol, beta-carotene, disodium pyrophosphate and the like extracted from the mulberry leaves are combined as feed additives, so that the diameters of pork muscle fibers are reduced, the density of muscle fibers is increased, and pork is relatively tender. The inhibition effect on mildew in the feed is strong, the feed mildew condition can be reduced, and the nutrient substances in the feed are protected from being damaged.

The invention belongs to the technical field of organic pharmaceutical co-crystals and particularly relates to a novel edaravone pharmaceutical co-crystal and a preparation method thereof. The edaravone pharmaceutical co-crystal takes edaravone as an active ingredient of the medicine and beta-cyclodextrin as a co-crystal formation; a basic structure unit of the edaravone pharmaceutical co-crystal consists of an edaravone molecule, a beta-cyclodextrin molecule and 10.5 water molecules, wherein a carbonyl oxygen atom and an amido nitrogen atom in the edaravone molecule are taken as a hydrogen bonding acceptor and hydroxyl in the beta-cyclodextrin molecule is taken as a hydrogen bonding donor to form two different intermolecular hydrogen bonds, and the antioxygenation of the edaravone is mainly exerted through clearing free radicals and inhibiting lipid peroxidation so as to inhibit the oxidative damage of brain cells, vascular endothelial cells and nerve cells. The co-crystal prepared by the invention keeps the pharmacological activity of the edaravone, and the solubility, the stability and the bioavailability are all remarkably improved. The result of the solubility test shows that the solubility of the pharmaceutical co-crystal is 6 times that of the edaravone.

The invention discloses a biphenyl furocoumarin compound and a preparation method and an application thereof; the provided biphenyl furocoumarin compound is a new compound with vasodilating activity, which is obtained by modifying and optimizing the structure based on a natural product imperatorin, reserving the pharmacological activity, improving the physicochemical property and enhancing the druggability. The preparation method of the biphenyl furocoumarin compound provided by the invention has the advantages of easily-obtained material source, mild reaction conditions, simple operation in reaction process, and cheap and easily-obtained reagents. The prepared biphenyl furocoumarin compound is a ramification of the imperatorin and has the effect similar to the imperatorin; an in vitro vascular ring tension research shows that the biphenyl furocoumarin compound has a relaxant effect on the mesenteric microvessels of rats, so that the biphenyl furocoumarin compound can be applied to preparing antihypertensive drugs.