A kind of edaravone drug co-crystal and preparation method thereof
A technology for edaravone and medicine is applied in the field of novel edaravone medicine co-crystal and the preparation field of the medicine co-crystal, and can solve the problems of poor stability of edaravone, decreased content of edaravone raw materials and the like
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Embodiment 1
[0053] Accurately weigh 39.9 mg of Edaravone and 260.1 mg of β-cyclodextrin, add 6 ml of a mixed solvent of ethanol and water (volume ratio 1:7), heat to 50-80 °C, and react for 0.5 h under stirring. Stirring was stopped, the temperature was lowered naturally, and after cooling down to room temperature, crystals were precipitated after standing still for 12-24 hours, which was the Edaravone / β-cyclodextrin eutectic.
Embodiment 2
[0055] Accurately weigh 39.9 mg of Edaravone and 260.1 mg of β-cyclodextrin, add 10 ml of a mixed solvent of methanol and water (volume ratio 1:1), heat to 50-65 ° C, and react for 0.5 h under stirring. Stirring was stopped, the temperature was lowered naturally, and after cooling down to room temperature, crystals were precipitated after standing still for 12-24 hours, which was the Edaravone / β-cyclodextrin eutectic.
Embodiment 3
[0057] Accurately weigh 39.9 mg of Edaravone and 260.1 mg of β-cyclodextrin, add 8 ml of a mixed solvent of isopropanol and water (volume ratio 1:5), heat to 50-80 °C, and react for 0.5 h under stirring. Stirring was stopped, the temperature was lowered naturally, and after cooling down to room temperature, crystals were precipitated after standing still for 12-24 hours, which was the Edaravone / β-cyclodextrin eutectic.
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