The invention relates to high-anthocyanin waxberry juice and a preparation method thereof, and belongs to the technical field of food processing. The preparation method comprises the following steps of taking waxberries as a main raw material, performing cleaning, performing denucleating and pulping, performing juicing by a spiral juicer, adding a mixed enzyme for enzymolysis, separating residues from liquid by a horizontal screw centrifuge, adding a composite auxiliary color agent for blending,performing treating by a colloid mill,performing filtering by a tubular centrifuge, performing sterilizing at ultra-high temperature, and performing canning to prepare the high-anthocyanin waxberry juice. The prepared waxberry juice is rich in anthocyanin, vitamin C, flavone, organic acid, myricetin and other food functional factors, is dark red, bright in color, sour, sweet, palatable and rich in fragrance, and has the dietary therapy effects of enhancing the immunity, regulating the gastrointestinal functions, reducing blood sugar, reducing blood fat, resisting aging, resisting mutation, resisting tumors and the like after being eaten for a long time. The method can guarantee the commodity and biological functions of the waxberry juice, improves the processing benefits of the waxberries, and has a good market prospect.