40results about How to "Reaction conditions are green and environmentally friendly" patented technology

The invention discloses a synthesis method of a natural product of E-2,3',4,5'-tetrahydroxy diphenyl ethylene. According to the method, 1,3-acetone dicarboxylic acid dimethyl ester is used as a starting raw material; condensation and aromatization reactions are performed to obtain 3,5-dihydroxy-2,4-dicarboxylate methyl phenyl acetate; then, hydrolysis and decarboxylation are performed to obtain 3,5-dyhydroxy phenylacetic acid; the 3,5-dyhydroxy phenylacetic acid and 2,4-dihydroxy benzaldehyde take condensation reaction under the existence of alkali to obtain 3-(3,5-dihydroxy phenyl)-7-hydroxy coumarin; next, open loop decarboxylation reaction is performed under the alkaline condition; the natural product of E-2,3',4,5'-tetrahydroxy diphenyl ethylene is obtained. The method has the advantages that the raw materials are easily obtained; the reaction route is simple and fast; the operation is convenient; the yield is higher.

The invention relates to a method for preparing a straw-based resin fertilizer. The method comprises the following steps: step 1, grinding crop straws, screening, thereby obtaining straw powder; step 2, sequentially adding an acrylic acid solution, acrylamide, polyethylene glycol biacrylate, urea, K2S2O8 and the straw powder into the reactor under the cold bath and stirring conditions, adding water to the needed volume, thereby obtaining a monomer phase; step 3, adding cyclohexane and Span-60 into the reactor, slowly adding the monomer phase prepared by the step 2, adding Na2SO3, performing suction filtration after the reaction is ended, thereby obtaining bead gel, performing vacuum drying at the temperature of 42-48 DEG C for 4 hours, thereby obtaining the powdered straw-based salt-resistant resin controlled release fertilizer. According to the method disclosed by the invention, the straw-based super absorbent resin fertilizer is prepared at normal temperature, the heating is not needed during the reaction, the reaction is carried out at room temperature, and the method is mild in reaction conditions, energy-saving and environmentally friendly. The prepared fertilizer is high in water absorption and water-retaining property and good in controlled-release effect, and the preparation process is simple and low in price.

The invention discloses a bismuth-containing catalyst for preparation of glyceric acid through selective oxidation of glycerin and a preparation method of the catalyst. The bismuth-containing catalyst is characterized in that the catalyst takes bismuth as an active component and layered hydroxide or layered metal composite oxide as a carrier. The preparation method comprises steps as follows: a bismuth salt solution is prepared; a soluble metallic salt solution is prepared, the two solutions are slowly added to a certain quantity of soluble carbonate solutions for pH value adjustment, stirred at the constant temperature to be aged, cooled, washed to be neutral, subjected to suction filtration under reduced pressure and vacuum drying and then calcined, and the catalyst is obtained. The prepared catalyst is used for preparation of glyceric acid through selective oxidation of glycerin and has the characteristics of high glycerin conversion rate, good selectivity of the product, namely, glyceric acid, simple preparation method, good repeated use performance and low cost.

The invention discloses a method for synthesizing benzotriazole compounds, which comprises the following steps: subjecting o-nitroazoxy compounds of formula (III) to reduction reaction I under an alkaline condition by using water or an ethanol aqueous solution as a reaction solvent and glucose as a reducer; after full reaction, adding zinc chloride into the reaction system as a catalyst, and adding aluminum powder under an alkaline condition to perform a reduction ring-closure reaction II; and after the reaction is accomplished completely, obtaining the benzotriazole compounds of the formula (IV). The method provided by the method solves the problems of waste acid, lots of waste water and the like from a diazotization reaction, adopts mild reaction condition, is environment-friendly and low in cost and is an economic and practical environment-friendly technical route.

The invention discloses a microwave radiation-assisted synthesis method of N-methyl-2-cyano-3,4-disubstituted pyrrole compound, in which alkyne, trimethylcyanosilane, N,N ‑Dimethylformamide, catalyzed by sodium iodide and assisted by microwaves to carry out a one-pot reaction to generate N‑methyl‑2‑cyano‑3,4‑disubstituted pyrrole compounds. The method has good product selectivity, high yield, simple separation process, low catalyst cost, environmental friendliness, and is beneficial to industrial production and application.

The invention belongs to the technical field of organic chemistry, in particular to a method for efficiently synthesizing pyrazolo[1,5-c]quinazoline skeleton compounds under non-catalytic conditions. The structures of these compounds have been 1 H NMR, 13 C NMR, MS and other methods to characterize and confirm. The present invention uses o-nitrobenzaldehyde and triethyl orthoformate series compound reaction to make 1,3-dipole quinazoline dipole and β-nitrostyrene to react without any catalyst, and DMSO was used as the solvent, and a series of pyrazolo[1,5‑c]quinazoline derivatives were generated by the reaction at a temperature of 110 °C. This reaction can efficiently prepare pyrazolo[1,5-c]quinazolines. The method of the invention has mild reaction conditions, easy operation, greatly reduced cost compared with the previous reaction cost of 1,3-dipole quinazoline dipoles and terminal alkynes, and the reaction conditions are green and environmentally friendly, and the product has high purity and is easy to separate Purification is suitable for large-scale preparation, and because the quinazoline compound skeleton has a wide range of biological activities, it has a very good application prospect in the development of new drugs.

The invention belongs to the technical field of preparation of steroid hormone intermediates, and in particular relates to a synthesis method of 6-ketoestradiol, which uses compound 1 as a raw material, and obtains 6-ketoestradiol through the following reaction route, The reaction route is as follows: the raw material of the present invention is different from estrone, has low price, wide sources and low cost. In the present invention, by optimizing the reaction route, when the 6-position carbonyl is introduced, the 6-position is the only active site, greatly increasing the selectivity of oxidation, and the reaction conditions are also green and environment-friendly. The invention provides a brand-new synthesis route of 6-ketoestradiol, which has mild process conditions, is environmentally friendly, and is suitable for industrial production.

The invention discloses a 1-methyl-2-cyano-3-aliphatic substituted pyrrole compound synthesis method, which comprises: carrying out a three-component addition reaction on terminal aliphatic hydrocarbon, trimethylcyano silane and N,N-dimethylformamide according to an equal chemical molar weight ratio under the catalytic action of ammonium iodide to generate a 1-methyl-2-cyano-3-aliphatic substituted pyrrole compound; and after the reaction is finished, washing the reaction system with saturated sodium sulfite, and extracting the water phase with ethyl acetate to obtain the high-purity 1-methyl-2-cyano-3-aliphatic substituted pyrrole compound. According to the invention, the method is good in product selectivity, high in yield, simple in separation process, low in catalyst cost, environmentally friendly and beneficial to industrial production and application.