The present invention discloses a contact lens care composition, which contains, by mass, 0.005-5.0% of a hyaluronic acid and antibacterial peptide bonding substance, 0.1-5.0% of a non-ionic surfactant, 0.5-9.0% of an inorganic salt, 0.001-5.0% of a buffer, 0.001-2.0% of a chelating agent, and the balance of sterilized water. According to the present invention, the antibacterial peptide in the formula can provide the disinfection and sterilization effect, and with the hyaluronic acid, the wetting of the contact lens can be ensured, and the gas permeation of the contact lens can be improved; and the contact lens care composition has characteristics of broad-spectrum antibacterial property, cleaning property, moisturizing, mild formula, no irritating and high stability, can be used for cleaning, disinfecting and storage of the contact lens, and can further be used as the wetting agent when wearing the contact lenses.