40results about How to "Increase local drug concentration" patented technology

Disclosed are methods of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject a tumescent composition comprising: (a) the drug or the therapeutic agent, wherein a tumescent concentration of the drug is simultaneously: 1) below a threshold for local, subcutaneous tissue toxicity, 2) above a threshold for positive local therapeutic effect, and 3) above a concentration achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; (b) a vasoconstrictor; and (c) a pharmaceutically acceptable carrier. Some embodiments relate to a method of treating or preventing sepsis or Systemic Inflammatory Response Syndrome (SIRS) in a subject. Some embodiments relate to a tumescent solution for treating a localized viral infection, e.g., varicella-zoster (shingles), the tumescent solution comprising an antiviral agent.

The invention discloses sodium azulene sulfonate gel. The sodium azulene sulfonate gel is prepared from 0.05-1 weight part of sodium azulene sulfonate, 0.5-50 weight parts of a gel base material, 1-50 weight parts of a transdermal enhancer, 0.5-2.5 weight parts of a pH conditioning agent, 0.1-0.5 weight parts of an antiseptic and 40-65 weight parts of a solvent. The invention also provides a preparation method and a use of the sodium azulene sulfonate gel. The sodium azulene sulfonate gel has the advantages of good appearance, good coating performances, use convenience, good biocompatibility with skin, no irritation and no pollution on clothes, and has strong skin adhesion, good permeability and a high concentration on local skin.

A clinical minimally-invasive intervening type medicine feeding medical device comprises a guiding catheter and a catheter connecting piece. The guiding catheter comprises a catheter body and a guiding wire. The far end of the catheter body is suitable for being implanted into a human body. The catheter connecting piece at least comprises a fixing fin and a connector which are connected in sequence from the far end to the near end. The fixing fin is provided with a fin pipe. The catheter body is inserted in from the far end of the fin pipe of the fixing fin and penetrates out from the near end of the connector. Accordingly, medicine injected from the near end of the catheter body can reach the far end of the catheter body, and then the medicine reaches a human part which needs injection. According to the intervening type medicine feeding medical device, interventional therapy can be carried out conveniently and easily, the medicine can directly reach a focus, local medicine is high in concentration, clinical effect is obviously improved, the device can be used for curing diseases such as all kinds of prostatitis and hematospermia (cystospermitis) and can also be used for seminiferous duct radiography, and accordingly diagnosis on seminiferous duct diseases can be made.

The invention provides externally applied traditional Chinese medicine combination for treating chronic pelvic inflammatory disease through applying iontophoresis and a preparation method. The externally applied traditional Chinese medicine combination is prepared by the following raw materials in parts by weight: 45-55 parts of sargent gloryvine, 35-45 parts of dandelion, 35-45 parts of honeysuckle, 15-25 parts of poria cocos, 25-35 parts of cassia twig, 15-25 parts of rhizoma zingiberis, 25-35 parts of peach kernel, 15-25 parts of safflower carthamus, 35-45 parts of salvia miltiorrhiza, 25-35 parts of red peony root, 25-35 parts of leonurus, 15-25 parts of manis pentadactyla, 35-45 parts of sparganii, 35-45 parts of curcuma zedoary, 25-35 parts of herba lycopi, 25-35 parts of ligusticum wallichii, 25-35 parts of corydalis tuber and 15-25 parts of liquorice. The preparation method comprises the following steps of: firstly crushing the manis pentadactyla; mixing the crushed manis pentadactyla and other traditional Chinese medicines; soaking by fresh water for 35-45 minutes, boiling through high heat; decocting for 25-35 minutes through slow fire; decocting for two times; and refrigerating for standby after mixing, concentrating and filtering the medicines. The externally applied traditional Chinese medicine combination for treating the chronic pelvic inflammatory disease through applying the iontophoresis has the advantages of high cure rate, good curative effect, low treatment expense and little side effect.

The invention relates to a vancomycin slow release microsphere with magnetic filed compliance and a preparation method thereof. The preparation method comprises the following steps: dissolving chitosan in organic solvent with emulsifying method, dispersing vancomycin and nanoscale ferroferric oxide magnetic powder, then slowly adding dispersing medium, and then adding surfactant, so that water and oil phase are mutually formed as one phase and surface tension is decreased; after emulsifying, adding crosslinking agent, so that chitosan crosslinks to form macromolecule and enwrap the vancomycin and ferroferric oxide magnetic powder; and finally, filtering and drying to obtain vancomycin slow release microsphere with magnetic filed compliance. After being infused to body, the microsphere can gather in local pathologic change part under guidance of outer magnetic field so as to improve local drug concentration and reach the purpose of targeted therapy of drug. The use of the vancomycin slow release microsphere with magnetic filed compliance can greatly improve the efficiency of drugs.

The invention belongs to the field of medicinal preparations, and particularly relates to lomefloxacin hydrochloride emulsifiable paste and a preparation method thereof. The lomefloxacin hydrochloride emulsifiable paste comprises the following components in part by weight: 0.5 to 5 parts of lomefloxacin hydrochloride, 6.8 to 105 parts of oil phase component, 52.01 to 165 parts of water phase component and 0.01 to 5 parts of preservative. The prepared paste can act on infected parts directly, so that local medicinal concentration is high, and adverse reaction caused by oral administration or venous administration is avoided. The lomefloxacin hydrochloride emulsifiable paste is definite in curative effect, and a process is stable and is suitable for large-scale industrial production.

The invention belongs to the field of medicine bioengineering and particularly relates to a drug composition containing glutathione (GSH) and an application of the drug composition. More particularly, the invention provides an application of reduced GSH to preparation of drugs for promoting diabetic implant bone integration, and further provides the drug composition containing GSH. The drug composition can promote diabetic implant bone integration and comprises GSH and other drugs, wherein the other drugs are preferably selected from resveratrol and / or insulin. Furthermore, the invention provides a drug preparation containing the drug composition and a preparation method of the drug preparation; the drug preparation is preferably selected from sustained-release microspheres.

The invention discloses a dasatinib nanopreparation, which consists of dasatinib, auxiliary material and additive; the dasatinib is 5 to 40 parts by weight, the auxiliary material is 30 to 80 parts by weight, the additive is 10 to 40 parts by weight, and the grain size of the dasatinib is less than 1Mu m. The invention further discloses a preparation method for the preparation. The invention optimizes the grain size and dissolubility of the nanodrug by adjusting the composition of the auxiliary material, concentration and preparation process parameters, so that the dissolubility of the drug is greatly increased, and the dissolution rate of the drug in 15 minutes reaches 91 to 94 percent; moreover, the production process is simple, the dasatinib nanopreparation can be mass-produced, methods, such as high temperature, high pressure and chemical reaction, which can easily destroy the ingredients of the drug are not needed, the process conditions are mild, and thereby industrialization is benefited.

A tumescent composition including a cannabinoid dissolved in a tumescent solution, wherein the tumescent solution includes a local anesthetic; a vasoconstrictor; and a pharmaceutically acceptable carrier, wherein a tumescent concentration of the cannabinoid is 1-2000 μg / kg and is simultaneously: below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery. Also disclosed are methods of subcutaneous delivery of a cannabinoid to a subject including administering to the subject the tumescent composition.

The invention discloses a preparation method of a sustained-release medicine film. Sea buckthorn oil, glycerine, chitosan and bletilla striata are prepared into a circular medicine film, which is used for treatment for various tympanic membrane perforation, thus allowing the patients to avoid the operations, reducing the medical cost and being popularized in all levels of hospitals. The treatment cost of the tympanic membrane perforation by the medicine film is about one tenth of the operation cost, and the medicine film can promote the good healing of the tympanic membrane perforation, which can essentially replace the operation treatment. The operation treatment for the tympanic membrane perforation has high medical cost and is difficult to achieve the good healing of the tympanic membrane. The western region of China is rich in sea buckthorn resources which can maintain water and soil, green the environment, keep the ecological balance, and is in line with the policy of returning farmland to forest in the western loess plateau region of China. Thus, the development and the utilization of the sea buckthorn resources have important economic value and social significance. The research and development of the medicine film has great social and economic benefits, and promising prospects of popularization and application. The invention opens up the medicine film for the treatment for tympanic membrane perforation which is in line with the China's actual conditions.

The invention relates to a ketoprofen transdermal patch and a preparation method thereof. The ketoprofen transdermal patch comprises a backing layer, a drug-containing colloid layer and an anti-sticking layer, wherein the drug-containing colloid layer comprises ketoprofen, a humectant, an absorption enhancer, a colloid matrix material and an additive. The ketoprofen transdermal patch can improve the local drug concentration of a pain part, can regulate an administration dosage through control of an administration area, can interrupt administration at any time, is convenient in use, and improves the compliance of medication. The ketoprofen transdermal patch has a high drug loading capacity and a good transdermal absorption effect, is small in skin irritation, is free from allergy-prone components, is free from pollution; is good in breathability, is good in skin fitting performance, can be easily peeled off, does not have peculiar smells, does not have skin irritation or anaphylactic reaction, is high in safety, has a simple preparation technology, is easy in implementation, is good in stability, is used for treating rheumatism / rheumatic arthritis and has a good clinical effect.

Disclosed are methods of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject a tumescent composition comprising: (a) the drug or the therapeutic agent, wherein a tumescent concentration of the drug is simultaneously: 1) below a threshold for local, subcutaneous tissue toxicity, 2) above a threshold for positive local therapeutic effect, and 3) above a concentration achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; (b) a vasoconstrictor; and (c) a pharmaceutically acceptable carrier. Some embodiments relate to a method of treating or preventing sepsis or Systemic Inflammatory Response Syndrome (SIRS) in a subject. Some embodiments relate to a tumescent solution for treating a localized viral infection, e.g., varicella-zoster (shingles), the tumescent solution comprising an antiviral agent.

A suppository of terbinafine hydrochloride for treating the fungus infection of woman's reproduction tract is prepared from terbinafine hydrochloride, matrix and dissolving promoter. Its preparing process is also disclosed.

The invention discloses an externally applied composition and a preparation thereof, in particular an olopatadine hydrochloride containing externally applied composition and cream thereof. The composition contains olopatadine hydrochloride. The olopatadine hydrochloride containing externally applied composition directly acts on an affected part, the local medicament concentration of skin at an itching part is increased, and the effects of resisting histamine and stabilizing mast cells are achieved; adverse reaction of oral administration is avoided; the administration dosage can be selected according to the area of a diseased part, and the olopatadine hydrochloride containing externally applied composition is convenient to use and carry and high in stability; efficacy tests show that the composition has remarkable treatment effects on pruritic dermatosis; a process for the cream is simple, easy and low in cost.

The invention discloses a traditional Chinese medicine aerosol for treatment of infantile cough. According to traditional Chinese medical science, etiological factors of infantile cough include phlegm-heat accumulation, exterior disorder, interior and exterior inharmony, phlegm stagnation in air ways and failure of lung qi in dispersion. Therefore, traditional Chinese medicines including pyrrosialeaf, polygonum cuspidatum, citron fruit, angelica dahurica, fistular onion stalk, folium mori and amomum cardamomum, which have functions of freeing lung and relieving asthma, clearing lung heat, and eliminating phlegm and relieving a cough, are used for preparing the aerosol in the drug manufacturing room of the people's hospital of Yinan county. According to clinical tests in the people's hospital of Yinan county, the total effective rate reaches 97.3% which is evidently higher than control groups. The traditional Chinese medicine aerosol is externally and locally applied, high in medicineutilization rate, low in toxic and adverse effect, convenient in use, quick in effectiveness and worthy of clinical popularization and application.

The invention relates to a transarterial catheter double-targeted drug delivery monitoring and controlling system based on video supervision. The system comprises a living body information collectingmodule, a drug delivery instruction module, a via-tumor feeding artery drug delivery module and a living body evaluation module. The living body information collecting module is used for collecting living body state information. The drug delivery instruction module is used for generating a drug delivery instruction based on the living body state information. The via-tumor feeding artery drug delivery module executes the drug delivery instruction and is used for carrying out echeloning drug delivery of tumor vessel disrupters and radiolabeled necrosis affinity agents on a living body through alocal tumor feeding artery. The living body evaluation module is used for comprehensively evaluating the living body according to the state information of the living body after drug delivery is carried out, and an instruction for determining whether a drug is repeatedly delivered is generated and sent to the drug delivery instruction module. Compared with the prior art, the system has the advantages of being convenient to use, safe, reliable and the like, under the safe dose of systemic drug delivery, the local drug concentration on a focus is greatly increased, and therefore the treatment effect is greatly improved, and the toxic and side effects of other visceral organs are reduced.

The invention relates to a 2-methoxyestradiol dry powder inhalant serving as an antitumor medicament and a preparation method, which can be used for effectively solving the problems of poor oral administration effect and large administration dosage of 2-methoxyestradiol and short half-life period and the need of frequent administration in intravenous injection administration. According to the technical scheme for solving the problems, the 2-methoxyestradiol dry powder inhalant consists of the following components in percentage by weight: 50-90 percent of 2-methoxyestradiol, 0-5 percent of a flow aid, 5-50 percent of a thinner and 0-5 percent of a surfactant, wherein the flow aid is magnesium stearate or stearic acid; the thinner is one or a mixture of more than two of lactose, glucose, cane sugar and mannitol; and the surfactant is one of phospholipid, oleic acid and poloxamer. The antitumor medicament has the advantages of convenience in using, low administration dosage, small toxic and side effects, high stability, high safety and capability of directly reaching a focus, and is an innovation on a treatment means for treating tumors with 2-methoxyestradiol.

The invention provides externally applied traditional Chinese medicine combination for treating chronic pelvic inflammatory disease through applying iontophoresis and a preparation method. The externally applied traditional Chinese medicine combination is prepared by the following raw materials in parts by weight: 45-55 parts of sargent gloryvine, 35-45 parts of dandelion, 35-45 parts of honeysuckle, 15-25 parts of poria cocos, 25-35 parts of cassia twig, 15-25 parts of rhizoma zingiberis, 25-35 parts of peach kernel, 15-25 parts of safflower carthamus, 35-45 parts of salvia miltiorrhiza, 25-35 parts of red peony root, 25-35 parts of leonurus, 15-25 parts of manis pentadactyla, 35-45 parts of sparganii, 35-45 parts of curcuma zedoary, 25-35 parts of herba lycopi, 25-35 parts of ligusticum wallichii, 25-35 parts of corydalis tuber and 15-25 parts of liquorice. The preparation method comprises the following steps of: firstly crushing the manis pentadactyla; mixing the crushed manis pentadactyla and other traditional Chinese medicines; soaking by fresh water for 35-45 minutes, boiling through high heat; decocting for 25-35 minutes through slow fire; decocting for two times; and refrigerating for standby after mixing, concentrating and filtering the medicines. The externally applied traditional Chinese medicine combination for treating the chronic pelvic inflammatory disease through applying the iontophoresis has the advantages of high cure rate, good curative effect, low treatment expense and little side effect.

The invention discloses a preparation method for biodegradable recombinant human tissue type plasiminogen activator which realizes targeted release under ultrasonic control and application of the activator to promotion of lysis of hematoma, etc. Specifically, the invention relates to a slow-release medicinal preparation. The slow-release medicinal preparation comprises a human tissue type plasiminogen activator t-PV, pluronic F127 and water. The invention also discloses the function of a hydrogel and a micelle carrier in controlling drug release under ultrasonic action. The pluronic recombinant human tissue type plasiminogen activator is simple to prepare, suitable for large-scale production and especially applicable to removal of hematoma in the brain and preparation of antineoplastic drugs capable of realizing targetable drug delivery.

The invention discloses a traditional Chinese medicine composition for treating subacute thyroiditis, a subacute thyroiditis patch and a preparation method of the subacute thyroiditis patch. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-20 parts of rhizoma polygoni cuspidati, 7-30 parts of herba scutellariae barbatae, 5-20 parts of radix scutellariae, 7-30 parts of taraxacum mongolicum, 7-30 parts of herba violae, 3-12 parts of prepared frankincense, 3-12 parts of prepared myrrh and 1-6 parts of rheum officinale. The traditional Chinese medicine composition disclosed by the invention is simple in medicine flavor and low in price, and the subacute thyroiditis patch prepared from the traditional Chinese medicine composition has the characteristics of being simple, convenient, low in cost and effective. The subacute thyroiditis patch treats subacute thyroiditis through external application of Chinese medicine, and can intervene and control the illness state in the early stage, shorten the disease course, improve prognosis and reduce adverse reactions of the digestive tract; and compared with western medicines, the subacute thyroiditis patch is free of obvious toxic or side effect, is easily accepted by patients and has good compliance. The subacute thyroiditis patch marks a breakthrough in both the dosage and the administration mode, providing theoretical and clinical bases for external treatment of subacute thyroiditis through traditional Chinese medicine.

The invention relates to a recombinant human interferon alpha2a suppository and a preparation method thereof. Wherein the recombinant human interferon alpha2a is obtained by the following steps: utilizing an escherichia coli expression technology to construct a recombinant plasmid containing a human interferon alpha2a gene, and transforming into escherichia coli to obtain a stable engineering bacterium, fermenting the engineering bacterium, and purifying the engineering bacterium to obtain recombinant human interferon alpha2a, through sterile filtration, and mixing with glycerol and a gelatinmatrix, the recombinant human interferon alpha2a suppository is obtained. The formula of the matrix is characterized in that the matrix does not contain human serum albumin, wherein glycerol is not only an excipient, but also a bacteriostatic agent; the gelatin is also an excipient or a protease inhibitor, can effectively protect the protein of the recombinant human interferon alpha2a from being degraded, ensures the structural integrity of the recombinant human interferon alpha2a, stabilizes the biological activity of the interferon, can interfere with protease released by cells to further destroy damaged mucous membrane tissues of the vagina, and has a mucous membrane protection effect.

The invention discloses a dasatinib nanopreparation, which consists of dasatinib, auxiliary material and additive; the dasatinib is 5 to 40 parts by weight, the auxiliary material is 30 to 80 parts by weight, the additive is 10 to 40 parts by weight, and the grain size of the dasatinib is less than 1Mu m. The invention further discloses a preparation method for the preparation. The invention optimizes the grain size and dissolubility of the nanodrug by adjusting the composition of the auxiliary material, concentration and preparation process parameters, so that the dissolubility of the drug is greatly increased, and the dissolution rate of the drug in 15 minutes reaches 91 to 94 percent; moreover, the production process is simple, the dasatinib nanopreparation can be mass-produced, methods, such as high temperature, high pressure and chemical reaction, which can easily destroy the ingredients of the drug are not needed, the process conditions are mild, and thereby industrialization is benefited.

The invention discloses a traditional Chinese medicine aerosol for treatment of infantile cough. According to traditional Chinese medical science, etiological factors of infantile cough include phlegm-heat accumulation, exterior disorder, interior and exterior inharmony, phlegm stagnation in air ways and failure of lung qi in dispersion. Therefore, traditional Chinese medicines including pyrrosialeaf, polygonum cuspidatum, citron fruit, angelica dahurica, fistular onion stalk, folium mori and amomum cardamomum, which have functions of freeing lung and relieving asthma, clearing lung heat, and eliminating phlegm and relieving a cough, are used for preparing the aerosol in the drug manufacturing room of the people's hospital of Yinan county. According to clinical tests in the people's hospital of Yinan county, the total effective rate reaches 97.3% which is evidently higher than control groups. The traditional Chinese medicine aerosol is externally and locally applied, high in medicineutilization rate, low in toxic and adverse effect, convenient in use, quick in effectiveness and worthy of clinical popularization and application.

A suppository of terbinafine hydrochloride for treating the fungus infection of woman's reproduction tract is prepared from terbinafine hydrochloride, matrix and dissolving promoter. Its preparing process is also disclosed.

The present invention provides an application of sinomenine hydrochloride to the preparation of a drug for treating pain caused by rib fracture. The sinomenine hydrochloride may be used for preparingthe drug for treating pain caused by rib fracture. Compared with an opioid drug, a general anesthesia drug and a non-steroidal pain relieving drug, the sinomenine hydrochloride provided by the presentapplication has fewer adverse reactions. Compared with a method such as an intravenous injection method or a whole-body oral administration method, a local ashi-point injection method is higher in local drug concentration and better in pain relieving effect; and the sinomenine hydrochloride has a better treatment effect clinically in combination with an acupoint effect while taking a drug effect.The sinomenine hydrochloride provided by the present application is simple and convenient to operate due to no need of help from other people or equipment and instruments during treatment.

The invention relates to an injection for protecting ischemic myocardium and a preparation method thereof. In parts by mass, the emulsion for injection comprises: 1-5 parts of N-suberoylanilide hydroxamic acid; 0.2-12.5 parts of emulsifier 2-100 parts of injection oil; 0.02-5 parts of solubilizer; 0.03-0.4 parts of oleic acid; 0.4-12.5 parts of glycerin, and the balance of water for injection. The injection emulsion can be effectively used to improve the local drug concentration of N-suberoylanilide hydroxamic acid in cardiovascular and other lipophilic organs and / or tissues before cardiac interventional surgery, and increase the concentration of N-suberoylanilide hydroxamic acid. It can reduce the systemic side effects, effectively protect the myocardium in the state of ischemia or reperfusion injury, and reduce or avoid the occurrence of myocardial infarction. At the same time, the injection emulsion also provides a new alternative dosage form for the application of N-suberoylanilide hydroxamic acid in the treatment of cancer.

The invention discloses an externally applied composition and a preparation thereof, in particular an olopatadine hydrochloride containing externally applied composition and cream thereof. The composition contains olopatadine hydrochloride. The olopatadine hydrochloride containing externally applied composition directly acts on an affected part, the local medicament concentration of skin at an itching part is increased, and the effects of resisting histamine and stabilizing mast cells are achieved; adverse reaction of oral administration is avoided; the administration dosage can be selected according to the area of a diseased part, and the olopatadine hydrochloride containing externally applied composition is convenient to use and carry and high in stability; efficacy tests show that the composition has remarkable treatment effects on pruritic dermatosis; a process for the cream is simple, easy and low in cost.

The invention discloses an anti-angiogenic hydrogel sustained-release preparation and an application thereof. The hydrogel sustained-release preparation includes a HA-Tyr conjugate solution, an anti-angiogenic drug solution, an HPR solution, and hydrogen peroxide; and the HA-Tyr conjugate solution, the anti-angiogenic drug solution, the HPR solution, and the hydrogen peroxide are mixed in a volumeratio of 1:1 to 5: 0.02: 0.02. When the hydrogel sustained-release preparation is applied, the components are placed in a same syringe according to the ratio, the hydrogel sustained-release preparation is injected into the tumor site within 50s, the drug is slowly released at the tumor site, the concentration of local drug is increased, the concentration of blood is reduced, and systemic side effect is reduced; the local application of a drug carrier helps to improve the local inhibitory microenvironment of the tumor, the microenvironmental cellular components can be reorganized and balanced,which provide a synergistic pathway for synergy with other treatments.